Melanocortin-4 receptor in sheep: A potential site for therapeutic intervention in disease models

Domestic Animal Endocrinology

Volumn 29, Issue 2, 2005, Pages 446-455

  Sartin, J L ^a   Wagner, C G ^a   Marks, D L ^b   Daniel, J A ^c   McMahon, C D ^d   Obese, F Y ^a   Partridge, C ^a  

^a AUBURN UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SOUTH DAKOTA STATE UNIVERSITY   (United States)

^d RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

AGRP; Appetite; Endotoxin; MSH; NPY

Indexed keywords

AGOUTI RELATED PROTEIN; AGOUTI-RELATED PROTEIN; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE; PROTEIN; SIGNAL PEPTIDE;

ANIMAL; CACHEXIA; CONFERENCE PAPER; DIET RESTRICTION; DISEASE MODEL; DRUG ANTAGONISM; EATING DISORDER; FOOD; FOOD INTAKE; GENERAL ASPECTS OF DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY; SHEEP; SHEEP DISEASE;

ANIMALS; APPETITE REGULATION; CACHEXIA; DISEASE; DISEASE MODELS, ANIMAL; EATING DISORDERS; FASTING; FOOD; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 4; SHEEP; SHEEP DISEASES;

AGOUTI; ANIMALIA; OVIS ARIES; RODENTIA;

EID: 21544471539     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2005.02.027     Document Type: Conference Paper

References (54)

1. T.H. Elsasser, S. Kahl, N.C. Steele, and T.S. Rumsey Nutritional modulation of somatotropic axis-cytokine relationships in cattle: a brief review Comp Biochem Physiol 116 1997 209 221
2. J.L. Sartin, M.A. Shores, D.D. Schwartz, and R.J. Kemppainen Reduced growth of calves and its reversal by use of anabolic agents Domest Anim Endocrinol 19 2000 85 92
3. R.W. Johnson Immune and endocrine regulation of food intake in sick animals Domest Anim Endocrinol 15 1998 309 319
4. J.A. Daniel, M.S. Abrams, L. deSouza, C.G. Wagner, B.K. Whitlock, and J.L. Sartin Endotoxin inhibition of luteinizing hormone in sheep Domest Anim Endocrinol 25 2003 13 19
5. C.D. McMahon, D.F. Buxton, T.H. Elsasser, D.R. Gunter, L.G. Sanders, and B.P. Steele Neuropeptide Y restores appetite and alters concentrations of growth hormone (GH) after central administration to endotoxic sheep J Endocrinol 161 1999 333 339
6. J.L. Sartin, C. Dyer, R. Matteri, D. Buxton, F. Buonomo, and M.A. Shores Effect of intracerebroventricular orexin-B on food intake in sheep J Anim Sci 79 2001 1573 1577
7. C.J. Dyer, K.J. Touchette, J.A. Carroll, G.L. Allee, and R.L. Matteri Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs Domest Anim Endocrinol 16 1999 145 148
8. J.L. Miner, M.A. Della-Fera, J.A. Paterson, and C.A. Baile Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep Am J Physiol 257 1989 R383 R387
9. M.A. Cowley, J.L. Smart, M. Rubinstein, M.G. Cerdan, S. Diano, and T.L. Horvath Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 411 2001 480 484
10. D.L. Marks, and R.D. Cone Central melanocortins and the regulation of weight during acute and chronic disease Rec Progr Horm Res 56 2001 359 375
11. R.L. Batterham, M.A. Cowley, C.J. Small, H. Herzog, M.A. Cohen, and C.L. Dakin Gut hormone PYY(3-36) physiologically inhibits food intake Nature 418 2002 650 654
12. Z.A. Archer, S.M. Rhind, P.A. Findlay, C.E. Kyle, L. Thomas, and M. Marie Contrasting effects of different levels of food intake and adiposity on LH secretion and hypothalamic gene expression in sheep J Endocrinol 175 2002 383 393
13. D.M. Jacobowitz, and T.L. O'Donohue alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain Proc Natl Acad Sci USA 75 1978 6300 6304
14. A. Inui Feeding and body-weight regulation by hypothalamic neuropeptides - mediation of the actions of leptin Trends Neurosci 22 1999 62 67
15. C.J. Billington, J.E. Briggs, M. Grace, and A.S. Levine Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism Am J Physiol 260 1991 R321 R327
16. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 371 1997 799 802
17. D. Huszar, C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore, Q. Fang, and Q. Berkmeier Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141
18. C. Haskell-Luevano, P. Chen, K. Vhang, M.S. Smith, J.L. Cameron, and R.D. Cone Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat Endocrinology 140 1999 1408 1415
19. C. Broberger, C. Johansson, M. Stalling, and T. Hokfelt The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice Proc Natl Acad Sci USA 95 1998 15043 15048
20. B.A. Henry, A.J. Tilbrooke, F.R. Dunshea, A. Rao, D. Blache, and G.B. Martin Long-term alterations in adiposity affect the expression of melanin-concentrating hormone and enkephalin but not proopiomelanocortin in the hypothalamus of ovariectomized ewes Endocrinology 141 2000 1506 1514
21. T.M. McShane, S.L. Petersen, S. McCrone, and D.H. Keisler Influence of food restriction on neuropeptide-Y, proopiomelanocortin, and luteinizing hormone-releasing hormone gene expression in sheep hypothalami Biol Reprod 49 1993 831 839
22. B.A. Henry, A. Rao, B.A. Ikenasio, K.G. Mountjoy, A.J. Tilbrook, and I.J. Clarke Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep Brain Res 918 2001 40 50
23. C.L. Adam, Z.A. Archer, P.A. Findlay, L. Thomas, and M. Marie Hypothalamic gene expression in sheep for cocaine- and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance Neuroendocrinology 75 2002 250 256
24. B.S. Mulhausler, I.C. McMillen, G. Rouzaud, P.A. Findlay, E.M. Marrocco, and S.M. Rhind Appetite regulatory neuropeptides are expressed in the sheep hypothalamus before birth J Neuroendocrinol 16 2004 502 507
25. I.J. Clarke, C.J. Scott, A. Rao, S. Pompolo, and M.L. Barker-Gobb Seasonal changes in the expression of neuropeptide Y and pro-opiomelanocortin mRNA in the arcuate nucleus of the ovariectomized ewe: relationship to the seasonal appetite and breeding cycles J Neuroendocrinol 12 2000 1105 1111
26. J. Iqbal, S. Pompolo, T. Murakami, E. Grouzmann, T. Sakurai, and B. Meister Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus Brain Res 920 2001 55 64
27. J. Polkowska, and A. Gladysz Effect of food manipulation on the neuropeptide Y neuronal system in the diencephalon of ewes J Chem Neuroanat 21 2001 149 159
28. L.M. Williams, C.L. Adam, J.G. Mercer, K.M. Moar, D. Slater, and L. Hunter Leptin receptor and neuropeptide Y gene expression in the sheep brain J Neuroendocrinol 11 1999 165 169
29. J. Iqbal, S. Pompolo, L.M. Dumont, C.S. Wu, K.G. Mountjoy, and B.A. Henry Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and -4 mRNA in the ovine hypothalamus Neuroscience 105 2001 931 940
30. A. Sorenson, C.L. Adam, P.A. Findlay, M. Marie, L. Thomas, and M.T. Travers Leptin secretion and hypothalamic neuropeptide and receptor gene expression in sheep Am J Physiol Regul Integr Comp Physiol 282 2002 R1227 R1235
31. B.K. Whitlock, J.A. Daniel, C.D. McMahon, F.C. Buonomo, C.G. Wagner, and B. Steele Intracerebroventricular melanin-concentrating hormone stimulates food intake in sheep Domest Anim Endocrinol 28 2005 224 232
32. C.G. Wagner, C.D. McMahon, D.L. Marks, J.A. Daniel, and J.L. Sartin A role for AGRP in appetite regulation in a species with continuous nutrient delivery Neuroendocrinology 80 2004 210 218
33. M.S. Kim, M. Rossi, C.R. Abbott, S.H. AlAhmed, D.M. Smith, and S.R. Bloom Sustained orexigenic effect of agouti related protein may be not mediated by the melanocortin 4 receptor Peptides 23 2002 1069 1076
34. C.R. Barb, A.S. Robertson, J.B. Barrett, R.R. Kraeling, and K.L. Houseknecht The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig J Endocrinol 181 2004 39 52
35. K.S. Kim, J.M. Reecy, W.H. Hsu, L.L. Anderson, and M.F. Rothschild Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pigs Domest Anim Endocrinol 26 2004 75 86
36. W. Langhans, and B. Hrupka Interleukins and tumor necrosis factor as inhibitors of food intake Neuropeptides 33 1999 415 424
37. H.D. McCarthy, S. Dryden, and G. Williams Interleukin-1 beta-induced anorexia and pyrexia in rat: relationship to hypothalamic neuropeptide Y Am J Physiol 269 1995 E852 E857
38. G. Sonti, S.E. Ilyin, and C.R. Plata-Salaman Neuropeptide Y blocks and reverses interleukin-1 beta-induced anorexia in rats Peptides 17 1996 517 520
39. J.M. Scarlett, M.A. Joppa, S. Markison, A.C. Foster, G. Brookhart, and D.L. Marks Direct activation of the hypothalamic melanocortin system by interleukin-I Proc Endocrine Soc 2004 77
40. R.M. Bluthe, R. Dantzer, and K.W. Kelley Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat Brain Res 573 1992 318 320
41. S. Taherzadeh, S. Sharma, V. Chhajlani, I. Gantz, N. Rajora, and M.T. Demitri alpha-MSH and its receptors in regulation of tumor necrosis factor-alpha production by human monocyte/macrophages Am J Physiol 276 1999 R1289 R1294
42. Q.H. Huang, V.J. Hruby, and J.B. Tatro Systemic alpha-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release Am J Physiol 276 1999 R864 R871
43. M.A. Cowley, N. Pronchuk, W. Fan, D.M. Dinulescu, W.F. Colmers, and R.D. Cone Ntegration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat Neuron 24 1999 155 163
44. W. Fan, B.A. Aoston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385 1997 165 168
45. S. Bluher, M. Ziotopoulou, J.W. Bullen Jr, S.J. Moschos, L. Ungsunan, and E. Kokkotou Responsiveness to peripherally administered melanocortins in lean and obese mice Diabetes 53 2004 82 90
46. A. Catania, M. Cutuli, L. Garofalo, L. Airaghi, F. Valenza, and J.M. Lipton Plasma concentrations and anti-l-cytokine effects of alpha-melanocyte stimulating hormone in septic patients Crit Care Med 28 2000 1403 1407
47. D.L. Marks, N. Ling, and R.D. Cone Role of the central melanocortin system in cachexia Cancer Res 61 2001 1432 1438
48. D.L. Marks, A.A. Butler, G.B. Brookhart, R.A. Turner, and R.D. Cone Differential role of melanocortin receptor subtypes in cachexia Endocrinology 144 2003 1513 1523
49. D. Bagnol, X.Y. Lu, C.B. Kaelin, H.E. Day, M. Ollmann, and I. Gantz Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain J Neurosci 19 1999 RC26
50. A.A. Butler, R.A. Kesterson, K. Khong, M.J. Cullen, M.A. Pelleymounter, and J. Dekoning A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse Endocrinology 141 2000 3518 3521
51. A.S. Chen, D.J. Marsh, M.E. Trumbauer, E.G. Frazier, X.M. Guan, and H. Yu Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass Nat Genet 26 2000 97 102
52. N.L. Jenkins, J.L. Turner, S.S. Dritz, S.K. Durham, and J.E. Minton Changes in circulating insulin-like growth factor-I, insulin-like growth factor binding proteins, and leptin in weaned pigs infected with Salmonella enterica serovar Typhimurium Domest Anim Endocrinol 26 2004 49 60
53. J.A. Daniel, T.H. Elsasser, C.D. Morrison, D.H. Keisler, B.K. Whitlock, and B. Steele Localization of leptin, tumor necrosis factor-α, and CD14 in ovine adipose and changes in circulating TNF in lean and obese sheep J Anim Sci 81 2003 2590 2599
54. C.G. Wagner, C.D. McMahon, D.L. Marks, J.A. Daniel, and J.L. Sartin Anorectic effects of lipopolysaccharide are prevented by intracerebroventricular injection of agouti related protein Proc Endocrine Soc 2004 324