Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats

Peptides

Volumn 17, Issue 3, 1996, Pages 517-520

  Sonti, Gayatri ^a   Ilyin, Sergey E ^a   Plata Salamán, Carlos R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Anorexia; Behavior; Cerebrospinal fluid; Cytokine; Feeding; Food intake; Growth factor; ICV administration; Immune system; Immunomodulator; Interleukin; Nervous system; Neuroimmunology; Neuropeptide Y; Rat

Indexed keywords

INTERLEUKIN 1BETA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; DOSE RESPONSE; FEEDING BEHAVIOR; FOOD INTAKE; INFUSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029927139     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(96)00016-2     Document Type: Article

References (17)

1. Burtis, C. A.; Ashwood, E. R. Tietz textbook of clinical chemistry, 2nd ed. Philadelphia: Saunders Company; 1994.
2. Chance, W. T.; Balasubramaniam, A.; Dayal, R.; Brown, J.; Fischer, J. E. Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats. Life Sci. 54:1869-1874; 1994.
3. Chance, W. T.; Balasubramaniam, A.; Fischer, J. E. Neuropeptide Y and the development of cancer anorexia. Ann. Surg. 221:579-589; 1995.
4. Currie, P. J.; Coscina, D. V. Dissociated feeding and hypothermie effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides 16:599-604; 1995.
5. Dube, M. G.; Sahu, A.; Kalra, P. S.; Kalra, S. P. Neuropeptide Y release is elevated from the microdissected paraventricular nucleus of food-deprived rats: An in vitro study. Endocrinology 131:1195-1201; 1992.
6. Jolicoeur, F. B.; Bouali, S. M.; Fournier, A.; St-Pierre, S. Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. Brain Res. Bull. 36:125-129; 1995.
7. Kalra, S. P.; Dube, M. G.; Sahu, A.; Phelps, C. P.; Kalra, P. S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA 88:10931-10935; 1991.
8. Kent, S.; Rodriguez, F.; Kelley, K. W.; Dantzer, R. Reduction of food and water intake induced by microinjection of interleukin-1β in the ventromedial hypothalamus of the rat. Physiol. Behav. 56:1031-1036; 1994.
9. Leibowitz, S. F.; Alexander, J. T. Analysis of neuropeptide Y-induced feeding : Dissociation of Y1 and Y2 receptor effects on natural meal patterns. Peptides 12:1251-1260; 1991.
10. Li, B.-H.; Xu, B.; Rowland, N. E.; Kalra, S. P. c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption. Brain Res. 665:277-284; 1994.
11. Mrosovsky, N.; Molony, L. A.; Conn, C.A.; Kluger, M. J. Anorexic effects of interleukin-1 in the rat. Am. J. Physiol. 257:R1315-R1321; 1989.
12. Opara, E. I.; Laviano, A.; Meguid, M. M.; Yang, Z. J. Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats. Neuroreport 6:750-752; 1995.
13. Plata-Salamán, C. R. Meal patterns in response to the intracerebroventricular administration of interleukin-1β in rats. Physiol. Behav. 55:727-733; 1994.
14. Stanley, B. G.; Chin, A.S.; Leibowitz, S. F. Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action. Brain Res. Bull. 14:521-524; 1985.
15. Stanley, B.G.; Magdalin, W.; Seirafi, A.; Nguyen, M. M.; Leibowitz, S. F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 13:581-587; 1992.
16. Steinman, J. L.; Gunion, M. W.; Morley, J. E. Forebrain and hindbrain involvement of neuropeptide Y in ingestive behaviors of rats. Pharmacol. Biochem. Behav. 47:207-214; 1994.
17. Tempel, D, L.; Leibowitz, S. F. Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN. Brain Res. Bull. 25:821-825; 1990.