Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress

Journal of Lipid Research

Volumn 37, Issue 1, 1996, Pages 67-75

  Lagendijk, Jennifer ^a   Ubbink, Johan B ^a   Hayward Vermaak, W J ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

HPLC; Oxidative stress; Ubiquinol ubiquinone ratio

Indexed keywords

UBIDECARENONE; UBIQUINONE;

ARTICLE; ATHEROGENESIS; CHOLESTEROL BLOOD LEVEL; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID PEROXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LINEAR MODELS; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; SPECIMEN HANDLING; UBIQUINONE;

EID: 0030071843     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Zubay, G. 1983. Biochemistry. Addison-Wesley Publishing Company, Menlo Park, CA. 373-374.
2. 10, α-tocopherol and free cholesterol in HDL and LDL fractions. Ann. Med. 23: 649-656.
3. Stocker, R., V. W. Bowry, and B. Frei. 1991. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. USA. 88: 1646-1650.
4. Ernster, L., and P. Forsmark-Andrée. 1993. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin. Invest. 71: S60-S65.
5. Esterbauer, H., G. Wag, and H. Puhl. 1993. Lipid peroxidation and its role in atherosclerosis. Br. Med. Bull. 49: 566-576.
6. Bowry, V. W., K. K. Stanley, and R. Stocker. 1992. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc. Natl. Acad. Sci. USA. 89: 10316-10320.
7. Dudman, N. P. B., D. E. L. Wilcken, and R. Stocker. 1993. Circulating lipid hydroperoxide levels in human hyperhomocysteinemia. Arterioscler. Thromb. 13: 512-516.
8. Vadhanavikit, S., N. Sakamoto, N. Ashida, T. Kishi, and K. Folkers. 1984. Quantitative determination of coenzyme Q-10 in human blood for clinical studies. Anal. Biochem. 142: 155-158.
9. Okamoto, T., K. Fukui, M. Nakamoto, T. Kishi, N. Kanamori, K. Kataoka, S. Nishii, H. Kishi, E. Hiraoka, and A. Okada. 1986. Serum levels of coenzyme Q-10 and lipids in patients during total parental nutrition. J. Nutr. Sci. Vitaminol. 32: 1-12.
10. Morimoto, H., I. Imada, T. Amano, M. Yoyoda, and Y. Ashida. 1973. Ubiquinone and related compounds: determination of ubiquinone-10 in human blood. Biochem. Med. 7: 169-177.
11. Muratsu, K., J. Komorowski, S. Zong-xuan, and K. Folkers. 1988. A superior analysis of coenzyme Q10 in blood of human, rabbits and rats for research. Biofactors. 1: 157-159.
12. Lang, J. K., K. Gohil, and L. Packer. 1986. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal. Biochem. 157: 106-116.
13. Lang, J. K., and L. Packer. 1987. Quantitative determination of vitamin E and oxidized and reduced coenzyme Q by HPLC with in-line ultraviolet and electrochemical detection. J. Chromatogr. 385: 109-117.
14. Katayama, K., M. Takada, T. Yuzuriha, K. Abe, and S. Ikenoya. 1980. Simultaneous determination of ubiquinone-10 and ubiquinol-10 in tissues and mitochondria by HPLC. Biochem. Biophys. Res. Commun. 95: 971-977.
15. 10 and α-tocopherol in biological samples by high performance liquid chromatography with platinum catalyst reduction and electrochemical detection. Biol. Pharm. Bull. 17: 997-1002.
16. Edlund, P. O. 1988. Determination of coenzyme Q-10, α-tocopherol and cholesterol in biological samples by coupled column LC with coulometric an ultraviolet detection. J. Chromatogr. 425: 87-97.
17. Stocker, R., and C. Suarna. 1993. Extracellular reduction of ubiquinone-1 and -10 by human HepG2 and blood cells. Biochim. Biophys. Acta. 1158: 15-22.
18. Dousset, J., M. Trouilh, and M. Foglietti. 1983. Plasma malonaldehyde levels during myocardial infarction. Clin. Chim. Acta. 129: 319-322.
19. Frei, B., Y. Yamamoto, D. Niclas, and B.N. Ames. 1988. Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plama. Anal. Biochem. 175: 120-130.
20. Wieland, E., V. Schettler, F. Diedrich, P. Schuff-Werner, and M. Oellerich. 1992. Determination of lipid hydroperoxides in serum. Idometry and high performance liquid chromatography compared. Eur. J. Clin. Chem. Clin. Biochem. 30: 363-369.