메뉴 건너뛰기




Volumn 113, Issue 6, 2004, Pages 924-932

DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR;

EID: 2142707263     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200417772     Document Type: Article
Times cited : (42)

References (55)
  • 1
    • 0021832394 scopus 로고
    • Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice
    • Kirkman, R.L., et al. 1985. Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice. J. Exp. Med. 162:358-362.
    • (1985) J. Exp. Med. , vol.162 , pp. 358-362
    • Kirkman, R.L.1
  • 2
    • 0024246540 scopus 로고
    • Interleukin 2 receptor-targeted therapy-rationale and applications in organ transplantation
    • Kupiec-Weglinski, J.W., Diamantstein, T., and Tilney, N.L. 1988. Interleukin 2 receptor-targeted therapy-rationale and applications in organ transplantation. Transplantation. 46:785-792.
    • (1988) Transplantation , vol.46 , pp. 785-792
    • Kupiec-Weglinski, J.W.1    Diamantstein, T.2    Tilney, N.L.3
  • 3
    • 0024365314 scopus 로고
    • Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help
    • Leist, T.P., Kohler, M., Eppler, M., and Zinkernagel, R.M. 1989. Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help. J. Immunol. 143:628-632.
    • (1989) J. Immunol. , vol.143 , pp. 628-632
    • Leist, T.P.1    Kohler, M.2    Eppler, M.3    Zinkernagel, R.M.4
  • 4
    • 0025215566 scopus 로고
    • Randomized controlled trial of a monoclonal antibody against the interleukin-2 receptor (33B3.1) as compared with rabbit antithymocyte globulin for prophylaxis against rejection of renal allografts
    • Soulillou, J.P., et al. 1990. Randomized controlled trial of a monoclonal antibody against the interleukin-2 receptor (33B3.1) as compared with rabbit antithymocyte globulin for prophylaxis against rejection of renal allografts. N. Engl. J. Med. 322:1175-1182.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1175-1182
    • Soulillou, J.P.1
  • 5
    • 0027252110 scopus 로고
    • The IL-2/IL-2 receptor system: A target for rational immune intervention
    • Waldmann, T.A. 1993. The IL-2/IL-2 receptor system: a target for rational immune intervention. Immunol. Today. 14:264-270.
    • (1993) Immunol. Today , vol.14 , pp. 264-270
    • Waldmann, T.A.1
  • 6
    • 0028564977 scopus 로고
    • Immunosuppression in small bowel transplantation-treatment with a monoclonal IL-2 receptor antibody (NDS 61)
    • Schwaizer, E., Papachrysanthou, A., Faendrich, F., Deltz, E., and Schroeder, P. 1994. Immunosuppression in small bowel transplantation-treatment with a monoclonal IL-2 receptor antibody (NDS 61). Transplant Proc. 26:3142-3143.
    • (1994) Transplant Proc. , vol.26 , pp. 3142-3143
    • Schwaizer, E.1    Papachrysanthou, A.2    Faendrich, F.3    Deltz, E.4    Schroeder, P.5
  • 7
    • 0030970637 scopus 로고    scopus 로고
    • Treatment of murine cardiac allograft by monoclonal antibodies to IL-2 receptor α chain and β chain
    • Isobe, M., et al. 1997. Treatment of murine cardiac allograft by monoclonal antibodies to IL-2 receptor α chain and β chain. Transplant Proc. 29:2301-2302.
    • (1997) Transplant Proc. , vol.29 , pp. 2301-2302
    • Isobe, M.1
  • 8
    • 0024441816 scopus 로고
    • The interleukin 2 receptor
    • Smith, K.A. 1989. The interleukin 2 receptor. Annu. Rev. Cell Biol. 5:397-425.
    • (1989) Annu. Rev. Cell Biol. , vol.5 , pp. 397-425
    • Smith, K.A.1
  • 9
    • 0027405991 scopus 로고
    • The IL-2 receptor complex: Its structure, function, and target genes
    • Minami, Y., Kono, T., Miyazaki, T., and Taniguchi, T. 1993. The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11:245-268.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 245-268
    • Minami, Y.1    Kono, T.2    Miyazaki, T.3    Taniguchi, T.4
  • 10
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • Taniguchi, T., and Minami, Y. 1993. The IL-2/IL-2 receptor system: a current overview. Cell. 73:5-8.
    • (1993) Cell , vol.73 , pp. 5-8
    • Taniguchi, T.1    Minami, Y.2
  • 11
    • 0024363480 scopus 로고
    • Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
    • Lohse, A.W., Mor, F., Karin, N., and Cohen, I.R. 1989. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science. 244:820-822.
    • (1989) Science , vol.244 , pp. 820-822
    • Lohse, A.W.1    Mor, F.2    Karin, N.3    Cohen, I.R.4
  • 12
    • 0027208981 scopus 로고
    • Induction of the anti-ergotypic response
    • Lohse, A.W., et al. 1993. Induction of the anti-ergotypic response. Int. Immunol. 5:533-539.
    • (1993) Int. Immunol. , vol.5 , pp. 533-539
    • Lohse, A.W.1
  • 13
    • 0030473601 scopus 로고    scopus 로고
    • IL-2 and TNF receptors as targets of regulatory T-T interactions: Isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat
    • Mor, F., Reizis, B., Cohen, I.R., and Steinman, L. 1996. IL-2 and TNF receptors as targets of regulatory T-T interactions: isolation and characterization of cytokine receptor-reactive T cell lines in the Lewis rat. J. Immunol. 167:4855-4861.
    • (1996) J. Immunol. , vol.167 , pp. 4855-4861
    • Mor, F.1    Reizis, B.2    Cohen, I.R.3    Steinman, L.4
  • 15
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang, J., Medaer, R., Stinissen, P., Hafler, D., and Raus, J. 1993. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science. 261:1451-1454.
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.4    Raus, J.5
  • 16
    • 0035852315 scopus 로고    scopus 로고
    • T-cell vaccination for autoimmune disease: A panorama
    • Cohen, I.R. 2001. T-cell vaccination for autoimmune disease: a panorama. Vaccine. 20:706-710.
    • (2001) Vaccine , vol.20 , pp. 706-710
    • Cohen, I.R.1
  • 17
    • 0031441192 scopus 로고    scopus 로고
    • + cells modulate autologous autoreactive neuroantigen-specific CD4+ T-cells by different mechanisms
    • + cells modulate autologous autoreactive neuroantigen-specific CD4+ T-cells by different mechanisms. J. Neuroimmunol. 80:47-64.
    • (1997) J. Neuroimmunol. , vol.80 , pp. 47-64
    • Correale, J.1    Rojany, M.2    Weiner, L.P.3
  • 18
    • 0032105479 scopus 로고    scopus 로고
    • γ/δ T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination
    • Stinissen, P., Zhang, J., Vandevyver, C., Hermans, G., and Raus, J. 1998. γ/δ T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination. J. Neuroimmunol. 87:94-104.
    • (1998) J. Neuroimmunol. , vol.87 , pp. 94-104
    • Stinissen, P.1    Zhang, J.2    Vandevyver, C.3    Hermans, G.4    Raus, J.5
  • 19
  • 20
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Wolff, J.A., et al. 1990. Direct gene transfer into mouse muscle in vivo. Science. 247:1465-1468.
    • (1990) Science , vol.247 , pp. 1465-1468
    • Wolff, J.A.1
  • 21
    • 0028385738 scopus 로고
    • Pharmacological enhancement of in vivo foreign gene expression in muscle
    • Danko, I., et al. 1994. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Ther. 1:114-121.
    • (1994) Gene Ther. , vol.1 , pp. 114-121
    • Danko, I.1
  • 22
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky, D.S. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity. 5:303-310.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 23
    • 8944253295 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
    • Sato, Y., et al. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science. 273:352-354.
    • (1996) Science , vol.273 , pp. 352-354
    • Sato, Y.1
  • 24
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: Immunology, application, and optimization
    • Gurunathan, S. Klinman, D.M., and Seder, R.A. 2000. DNA vaccines: immunology, application, and optimization. Annu. Rev. Immunol. 18:927-974.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 25
    • 9844265394 scopus 로고    scopus 로고
    • Toward clinical trials of DNA vaccines against malaria
    • Hoffman, S.L., et al. 1997. Toward clinical trials of DNA vaccines against malaria. Immunol. Cell Biol. 75:376-381.
    • (1997) Immunol. Cell Biol. , vol.75 , pp. 376-381
    • Hoffman, S.L.1
  • 26
    • 0032538597 scopus 로고    scopus 로고
    • Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
    • Wang, R., et al. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 282:476-480.
    • (1998) Science , vol.282 , pp. 476-480
    • Wang, R.1
  • 27
    • 0032210747 scopus 로고    scopus 로고
    • DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans
    • Ugen, K. E., et al. 1998. DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans. Vaccine. 16:1818-1821.
    • (1998) Vaccine , vol.16 , pp. 1818-1821
    • Ugen, K.E.1
  • 28
    • 0034002258 scopus 로고    scopus 로고
    • Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers
    • Le, T.P., et al. 2000. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine. 18:1893-1901.
    • (2000) Vaccine , vol.18 , pp. 1893-1901
    • Le, T.P.1
  • 29
    • 0035845527 scopus 로고    scopus 로고
    • Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine
    • Wang, R., et al. 2001. Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine. Proc. Natl. Acad. Sci. U. S. A. 98:10817-10822.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10817-10822
    • Wang, R.1
  • 30
    • 0029743818 scopus 로고    scopus 로고
    • The dominant and the cryptic T cell repertoire to myelin basic protein in the Lewis rat
    • Mor, F., Kanrorowitz, M., and Cohen, I.R. 1996. The dominant and the cryptic T cell repertoire to myelin basic protein in the Lewis rat. J. Neurosci. Res. 45:670-679.
    • (1996) J. Neurosci. Res. , vol.45 , pp. 670-679
    • Mor, F.1    Kanrorowitz, M.2    Cohen, I.R.3
  • 31
    • 0021335515 scopus 로고
    • Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II
    • Holoshitz, J., Matitiau, A., and Cohen, I.R. 1984. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J. Clin. Invest. 73:211-215.
    • (1984) J. Clin. Invest. , vol.73 , pp. 211-215
    • Holoshitz, J.1    Matitiau, A.2    Cohen, I.R.3
  • 32
    • 0024285835 scopus 로고
    • Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
    • van Eden, W., et al. 1988. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature. 331:171-173.
    • (1988) Nature , vol.331 , pp. 171-173
    • Van Eden, W.1
  • 33
    • 0018174365 scopus 로고
    • T cell growth factor: Parameters of production and a quantitative microassay for activity
    • Gillis, S., Ferm, M.M., Ou, W., and Smith, K.A. 1978. T cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 120:2027-2032.
    • (1978) J. Immunol. , vol.120 , pp. 2027-2032
    • Gillis, S.1    Ferm, M.M.2    Ou, W.3    Smith, K.A.4
  • 34
    • 0034090207 scopus 로고    scopus 로고
    • The specific regulation of immune responses by CD8+ T cells restricted by the MHC class 1b molecule, Qa-1
    • Jiang, H., and Chess, L. 2000. The specific regulation of immune responses by CD8+ T cells restricted by the MHC class 1b molecule, Qa-1. Annu. Rev. Immunol. 18:185-216.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 185-216
    • Jiang, H.1    Chess, L.2
  • 35
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self-tolerance
    • Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 36
    • 0033738329 scopus 로고    scopus 로고
    • The role of different subsets of T regulatory cells in controlling autoimmunity
    • Roncarolo, M.G., and Levings, M.K. 2000. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12:676-683.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 676-683
    • Roncarolo, M.G.1    Levings, M.K.2
  • 37
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach, E.M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423-449.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 39
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • Shevach, E.M. 2002. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 40
    • 0037105543 scopus 로고    scopus 로고
    • Inhibition of adjuvant arthritis by a DNA vaccine encoding human HSP60
    • Quintana, F.J., Carmi, P., Mor, F., and Cohen, I.R. 2002. Inhibition of adjuvant arthritis by a DNA vaccine encoding human HSP60. J. Immunol. 169:3422-3428.
    • (2002) J. Immunol. , vol.169 , pp. 3422-3428
    • Quintana, F.J.1    Carmi, P.2    Mor, F.3    Cohen, I.R.4
  • 41
    • 0031055339 scopus 로고    scopus 로고
    • Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65
    • Ragno, S., et al. 1997. Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65. Arthritis. Rheum. 40:277-283.
    • (1997) Arthritis. Rheum. , vol.40 , pp. 277-283
    • Ragno, S.1
  • 42
    • 0028299971 scopus 로고
    • Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols
    • Anderton, S.M., van der Zee, R., Noordzij, A., and van Eden, W. 1994. Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols. J. Immunol. 152:3656-3664.
    • (1994) J. Immunol. , vol.152 , pp. 3656-3664
    • Anderton, S.M.1    Van Der Zee, R.2    Noordzij, A.3    Van Eden, W.4
  • 43
    • 0027377220 scopus 로고
    • Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein
    • Lopez-Guerrero, J.A., et al. 1993. Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein. Infect. Immun. 61:4225-4231.
    • (1993) Infect. Immun. , vol.61 , pp. 4225-4231
    • Lopez-Guerrero, J.A.1
  • 44
    • 0028079811 scopus 로고
    • Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis
    • Lopez-Guerrero, J.A., Ortiz, M.A., Paez, E., Bernabeu, C., and Lopez-Bote, J.P. 1994. Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis. Arthritis Rheum. 37:1462-1467.
    • (1994) Arthritis Rheum. , vol.37 , pp. 1462-1467
    • Lopez-Guerrero, J.A.1    Ortiz, M.A.2    Paez, E.3    Bernabeu, C.4    Lopez-Bote, J.P.5
  • 45
    • 0033010444 scopus 로고    scopus 로고
    • Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
    • Boccaccio, G.L., Mor, F., and Steinman, L. 1999. Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis. Int. Immunol. 11:289-296.
    • (1999) Int. Immunol. , vol.11 , pp. 289-296
    • Boccaccio, G.L.1    Mor, F.2    Steinman, L.3
  • 46
    • 0034548005 scopus 로고    scopus 로고
    • Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity
    • Quintana, F.J., Rotem, A., Carmi, P., and Cohen, I.R. 2000. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity. J. Immunol. 165:6148-6155.
    • (2000) J. Immunol. , vol.165 , pp. 6148-6155
    • Quintana, F.J.1    Rotem, A.2    Carmi, P.3    Cohen, I.R.4
  • 47
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz, D., et al. 2002. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology. 122:1428-1441.
    • (2002) Gastroenterology , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1
  • 48
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux, H., et al. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 49
    • 0034327264 scopus 로고    scopus 로고
    • T regulatory cells 1 inhibit a Th2-specific response in vivo
    • Cottrez, F., Hurst, S.D., Coffman, R.L., and Groux, H. 2000. T regulatory cells 1 inhibit a Th2-specific response in vivo. J. Immunol. 165:4848-4853.
    • (2000) J. Immunol. , vol.165 , pp. 4848-4853
    • Cottrez, F.1    Hurst, S.D.2    Coffman, R.L.3    Groux, H.4
  • 50
    • 0034985055 scopus 로고    scopus 로고
    • Induction of a type 1 regulatory CD4 T cell response following V beta 8. 2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis
    • Kumar, V., et al. 2001. Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis. Int. Immunol. 13:835-841.
    • (2001) Int. Immunol. , vol.13 , pp. 835-841
    • Kumar, V.1
  • 51
    • 0034091286 scopus 로고    scopus 로고
    • γ/δ cells: A right time and a right place for a conserved third way of protection
    • Hayday, A.C. 2000. γ/δ cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 18:975-1026.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 975-1026
    • Hayday, A.C.1
  • 52
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 γ/δ T cells that prevent murine insulin-dependent diabetes
    • Harrison, L.C., Dempsey-Collier, M., Kramer, D.R., and Takahashi, K. 1996. Aerosol insulin induces regulatory CD8 γ/δ T cells that prevent murine insulin-dependent diabetes. J. Exp. Med. 184:2167-2174.
    • (1996) J. Exp. Med. , vol.184 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 53
    • 0030589323 scopus 로고    scopus 로고
    • Propagation and regulation of systemic autoimmunity by γ/δ T cells
    • Peng, S.L., Madaio, M.P., Hayday, A.C., and Craft, J. 1996. Propagation and regulation of systemic autoimmunity by γ/δ T cells. J. Immunol. 167:5689-5698.
    • (1996) J. Immunol. , vol.167 , pp. 5689-5698
    • Peng, S.L.1    Madaio, M.P.2    Hayday, A.C.3    Craft, J.4
  • 54
    • 0034002679 scopus 로고    scopus 로고
    • Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis
    • Zang, Y.C., et al. 2000. Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis. Eur. J. Immunol. 30:908-913.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 908-913
    • Zang, Y.C.1
  • 55
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton, A.M., and Shevach, E.M. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.