Enterolactone induces apoptosis and inhibits growth of colo 201 human colon cancer cells both in vitro and in vivo

Anticancer Research

Volumn 25, Issue 3 B, 2005, Pages 2269-2276

  Danbara, Naoyuki ^a   Yuri, Takashi ^a   Tsujita Kyutoku, Miki ^a   Tsukamoto, Reiko ^a   Uehara, Norihisa ^a   Tsubura, Airo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Colo 201; Colon cancer; Enterolactone

Indexed keywords

CASPASE 3; CASPASE 8; CYCLINE; ENTEROLACTONE; LIGNAN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; TETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER TRANSPLANTATION; CELL PROLIFERATION; COLON CANCER; COLORIMETRY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; LINSEED; MALE; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; TUMOR GROWTH; WESTERN BLOTTING;

4-BUTYROLACTONE; ADENOCARCINOMA; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASE 8; CASPASES; CELL GROWTH PROCESSES; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIN D1; FLOW CYTOMETRY; HUMANS; LIGNANS; MICE; MICE, NUDE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 21344468602     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Doll R and Peto R: The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1191-1308, 1981.
2. Potter JD: Risk factors for colon neoplasia - epidemiology and biology. Eur J Cancer 31A: 1033-1038, 1995.
3. Bartsch H, Nair J and Owen RW: Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20: 2209-2218, 1999.
4. Iigo M, Nakagawa T, Ishikawa C, Iwahori Y, Asamoto M, Yazawa K, Araki E and Tsuda H: Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. Br J Cancer 75: 650-655, 1997.
5. Iwamoto S, Senzaki H, Kiyozuka Y, Ogura E, Takada H, Hioki K and Tsubura A: Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. Nutr Cancer 31: 143-150, 1998.
6. Danbara N, Yuri T, Tsujita-Kyutoku M, Sato M, Senzaki H, Takada H, Hada T, Miyazawa T, Okazaki K and Tsubura A: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. Nutr Cancer 50: 71-79, 2004.
7. Adlercreutz H: Phyto-oestrogens and cancer. Lancet Oncol 3: 364-373, 2002.
8. Thompson LU, Robb P, Serraino M and Cheung F: Mammalian lignan production from various foods. Nutr Cancer 16: 43-52, 1991.
9. Thompson LU: Experimental studies on lignans and cancer. Baillieres Clin Endocrinol Metab 12: 691-705, 1998.
10. Serraino M and Thompson LU: Flaxseed supplementation and early markers of colon carcinogenesis. Cancer Lett 63: 159-165, 1992.
11. Jenab M and Thompson LU: The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity. Carcinogenesis 17: 1343-1348, 1996.
12. Davies MJ, Bowey EA, Adlercreutz H, Rowland IR and Rumsby PC: Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats. Carcinogenesis 20: 927-931, 1999.
13. Onogi N, Okuno M, Komaki C, Moriwaki H, Kawamori T, Tanaka T, Mori H and Muto Y: Suppressing effect of perilla oil on azoxymethane-induced foci of colonic aberrant crypts in rats. Carcinogenesis 17: 1291-1296, 1996.
14. Chen J, Tan KP, Ward WE and Thompson LU: Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. Exp Biol Med 228: 951-958, 2003.
15. Saarinen NM, Huovinen R, Warri A, Makela SI, Valentin-Blasini L, Sjoholm R, Ammala J, Lehtila R, Eckerman C, Collan YU and Santti RS: Enterolactone inhibits the growth of 7,12-dimethylbenz(α)anthracene-induced mammary carcinomas in the rat. Mol Cancer Ther 1: 869-876, 2002.
16. Wang C and Kurzer MS: Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr Cancer 28: 236-247, 1997.
17. Lin X, Switzer BR and Demark-Wahnefried W: Effect of mammalian lignans on the growth of prostate cancer cell lines. Anticancer Res 21: 3995-3999, 2001.
18. Sung MK, Lautens M and Thompson LU: Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells. Anticancer Res 18: 1405-1408, 1998.
19. Adlercreutz H: Does fiber-rich food containing animal lignan precursors protect against both colon and breast cancer? An extension of the "fiber hypothesis". Gastroenterology 86: 761-764, 1984.
20. Hirano T, Fukuoka K, Oka K, Naito T, Hosaka K, Mitsuhashi H and Matsumoto Y: Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1. Cancer Invest 8: 595-602, 1990.
21. Fotsis T, Pepper M, Adlercreutz H, Fleischmann G, Hase T, Montesano R and Schweigerer L: Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci USA 90: 2690-2694, 1993.
22. Semple TU, Quinn LA, Woods LK and Moore GE: Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model. Cancer Res 38: 1345-1355, 1978.
23. Geran RI, Greenberg NH, MacDonald MM, Schumacher AM and Abbott BJ: Protocol for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep 3: 1-103, 1972.
24. Adlercreutz H, Hockerstedt K, Bannwart C, Bloigu S, Hamalainen E, Fotsis T and Ollus A: Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem 27: 1135-1144, 1987.
25. Hausott B, Greger H and Marian B: Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. J Cancer Res Clin Oncol 129: 569-576, 2003.
26. Chen J, Stavro PM and Thompson LU: Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. Nutr Cancer 43: 187-192, 2002.
27. Dabrosin C, Chen J, Wang L and Thompson LU: Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett 185: 31-37, 2002.