Mammalian lignans inhibit the growth of estrogen-independent human colon tumor cells

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1405-1408

  Sung, Mi Kyung ^a,b   Lautens, M ^a   Thompson, Lilian U ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Sookmyung Women's University   (South Korea)

Author keywords

Anticarcinogen; Colon cancer; Estrogen; Lignans

Indexed keywords

ANTIESTROGEN; ANTINEOPLASTIC AGENT; BROXURIDINE; ENTERODIOL; ENTEROLACTONE; ESTRADIOL; LIGNAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON CANCER; COLON TUMOR; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL;

4-BUTYROLACTONE; ANIMALS; CELL DIVISION; COLONIC NEOPLASMS; ESTRADIOL; ESTROGENS; HUMANS; KINETICS; LIGNANS; MAMMALS; TUMOR CELLS, CULTURED;

EID: 0031829797     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Doll R, Peto R: The causes of cancer. Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 59: 1050-1060, 1981.
2. Wattenberg LW: Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 52: 2085s-2091s, 1992.
3. Slavin J, Jacobs D, Marquart L: Whole-grain consumption and chronic disease: Protective mechanisms. Nutr Cancer 27: 14-21, 1997.
4. Borriello SP, Setchell KDR, Axelson M, Lawson AM: Production and metabolism of lignans by the human fecal flora. J Appl Bacteriol 158: 37-43, 1985.
5. Thompson LU, Robb P, Serraino M, Cheung F: Mammalian lignan production from various foods. Nutr Cancer 16: 43-52, 1991.
6. Adlercreutz H, Fotsis T, Bannwart C el al. Determination of urinary lignans and phytoestrogens metabolites, potential antiestrogens and anticarcinogen in urine of women on various habitual diets. J Steroid Biochem 25: 791-797, 1986.
7. Adlercreutz H, Fotsis T, Heikkinen R, et al: Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian women and in women with breast cancer. Lancet ii: 1295-1299, 1982.
8. Thompson LU, Rickard S, Orcheson L, Seidl M: Flaxseed and its lignan and oil components reduce mammary tumor growth at its later stage of carcinogenesis. Carcinogenesis 17: 1373-1376, 1996.
9. Adlercreutz H, Mazur W: Phyto-oestrogens and western diseases. Ann Med 29: 95-120, 1997.
10. Jenab M, Thompson LU: The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity. Carcinogenesis 17: 1343-1348, 1996.
11. Serraino M, Thompson LU: The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Nutr Cancer 17: 153-159, 1992.
12. Wobbes T, Beex LVAM, Koenders AMT: Estrogen and progestin receptors in colonie cancer? Dis Colon Rectum 27: 591-592, 1984
13. Lointier P, Wildrick DM, Boman BM: Growth effects of tamoxifen on Lovo colon carcinoma cells and cultured cells from normal colonie mucosa. Anticancer Res 12: 1523-1526, 1992.
14. Kirk D, McLaughlin LM, Lawson AM, Setchell KDR, Patel SK: Synthesis of the [2H]-labelled urinary lignans enterolactone and estradiol. J Chem Soc Perkin Trans 1: 35-37, 1985.
15. Hirano T, Fukuoka K, Oka K, et al: Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1. Cancer Invest 8: 595-602, 1990.
16. Mousavi Y, Adlercreutz H: Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Molec Biol 41: 610-615, 1992.
17. Prasad K: Hydroxyl radical-scavanging property of secoisolariciresinol diglucoside (SDG) isolated from flaxseed. Mol Cell Biochem 168: 117-123, 1997.
18. Amarowicz R, Wanasundara U, Wanasundara J, Shahidi F: Antioxidant activity of ethanolic extracts of flaxseed in a , β-carotene -linolenic model system. J Food Lipids 1: 117, 1993.
19. Akiyama T, Ishida J, Nakagawa S, et al: Genistein, a specific inhibitor of tyrosine protein kinases. J Biol Chem 262: 5592-5595, 1987.
20. Yamashita Y, Kawada S, Nakano H: Induction of mammalian topoisomerase II dependent DNA cleavage by non-intercalative flavonoids genistein and orobol. FEBS Lett 288: 46-50, 1991.
21. Cummings JH, Banwell JC, Englyst HN, et al: The amount and composition of human large bowel contents. Gastroenterol 98: A408, 1990.