Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat

Molecular Cancer Therapeutics

Volumn 1, Issue 10, 2002, Pages 869-876

  Saarinen, Niina M ^a   Huovinen, Riikka ^b   Wärri, Anni ^a   Mäkelä, Sari I ^a,c   Valentín Blasini, Liza ^d   Sjöholm, Rainer ^e   Ämmälä, Jenni ^a   Lehtilä, Reko ^e   Eckerman, Christer ^e   Collan, Yrjö U ^a   Santti, Risto S ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^e ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BIS(3' HYDROXYBENZYL)BUTYROLACTONE; 2,3-BIS(3'-HYDROXYBENZYL)BUTYROLACTONE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; AROMATASE INHIBITOR; CARCINOGEN; DRUG DERIVATIVE; ENZYME INHIBITOR; ESTROGEN; GAMMA BUTYROLACTONE; ISOFLAVONE DERIVATIVE; LIGNAN; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT;

ANIMAL; ARTICLE; BLOOD; CELL DIVISION; CHEMICAL MODEL; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; METABOLISM; ORGAN SIZE; RAT; SPRAGUE DAWLEY RAT; TIME; URINE; UTERUS;

4-BUTYROLACTONE; 9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; AROMATASE INHIBITORS; CARCINOGENS; CELL DIVISION; ENZYME INHIBITORS; ESTROGENS; ESTROGENS, NON-STEROIDAL; FEMALE; ISOFLAVONES; LIGNANS; MAMMARY NEOPLASMS, ANIMAL; MODELS, CHEMICAL; ORGAN SIZE; PHYTOESTROGENS; PLANT PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UTERUS;

EID: 0036690593     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Axelson, M., and Setchell, K. D. The excretion of lignans in rats-evidence for an intestinal bacterial source for this new group of compounds. FEBS Lett., 123: 337-342, 1981. (Pubitemid 11148771)
2. Setchell, K. D., Lawson, A. M., Borriello, S. P., Harkness, R., Gordon, H., Morgan, D. M., Kirk, D. N., Adlercreutz, H., Anderson, L. C., and Axelson, M. Lignan formation in man-microbial involvement and possible roles in relation to cancer. Lancet, 2: 4-7, 1981. (Pubitemid 11038678)
3. Borriello, S. P., Setchell, K. D. R., Axelson, M., and Lawson, A. M. Production and metabolism of lignans by the human faecal flora. J. Appl. Bacteriol., 58: 37-43, 1985. (Pubitemid 15136128)
4. Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wähälä, K., Deyama, T., Nishibe, S., and Adlercreutz, H. In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J. Agric. Food Chem., 49: 3178-3186, 2001. (Pubitemid 32845044)
5. Ingram, D., Sanders, K., Kolybaba, M., and Lopez, D. Case-control study of phyto-oestrogens and breast cancer. Lancet, 350: 990-994, 1997. (Pubitemid 27421108)
6. Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J. T., Woods, M., and Goldin, B. R. Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet, 11: 1295-1298, 1982. (Pubitemid 13240915)
7. Pietinen, P., Stumpf, K., Mannisto, S., Kataja, B., Uusitupa, M., and Adlercreutz, H. Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol. Biomark. Prev., 10: 339-344, 2001. (Pubitemid 32703218)
8. Thompson, L. U., Robb, P., Serraino, M., and Cheung, F. Mammalian lignan production from various foods. Nutr. Cancer, 16: 43-52, 1991.
9. Thompson, L. U., Seidl, M. M., Rickard, S. E., Orcheson, L. J., and Fong, H. H. Antitumorigenic effect of a mammalian lignan precursor from flaxseed. Nutr. Cancer, 26: 159-165, 1996. (Pubitemid 26300195)
10. Thompson, L. U., Rickard, S. E., Orcheson, L. J., and Seidl, M. M. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis (Lond.), 17: 1373-1376, 1996. (Pubitemid 26197671)
11. Saarinen, N., Joshi, S. C., Ahotupa, M., Li, X., Ämmälä, J., Mäkelä, S., and Santti, R. No evidence for the in vivo activity of aromatase-inhibiting flavonoids. J. Steroid Biochem. Mol. Biol., 78: 231-239, 2001. (Pubitemid 32953617)
12. Saarinen, N. M., Huovinen, R., Wärri, A., Mäkelä, S. I., Valentín-Blasini, L., Needham, L., Eckerman, C., Collan, Y. U., and Santti, R. Uptake and metabolism of hydroxymatairesinol in relation to its anticarcinogenicity in DMBA-induced rat mammary carcinoma model. Nutr. Cancer, 41: 82-90, 2001. (Pubitemid 34666225)
13. Thompson, L. U., Chen, J., and Goss, P. E. Biological effects of dietary flaxseed in patients with breast cancer. Breast Cancer Res. Treat., 64: 50, 2000.
14. Demark-Wahnefried, W., Price, D. T., Polascik, T. J., Robertson, C. N., Anderson, E. E., Paulson, D. F., Walther, P. J., Gannon, M., and Vollmer, R. T. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology, 58: 47-52, 2001. (Pubitemid 32633934)
15. Kirk, D. N., Mc Laughlin, L. M., Lawson, A. M., Setchell, K. D. R., and Shailesh, K. P. Synthesis of the [2H]-labeled urinary lignans enterolactone and enterodiol. J. Chem. Soc. Perkin Trans. I., 85: 35-37, 1985.
16. Jacobs, E., and Metzler, M. Oxidative metabolism of the mammalian lignans enterolactone and enterodiol by rat, pig and human liver microsomes. J. Acric. Food Chem., 47: 1071-1077, 1999. (Pubitemid 29182965)
17. Ekman, R. Analysis of lignans in Norway spruce by combined gas chromatography-mass spectrometry. Holzforschung, 30: 79-85, 1976.
18. Freudenberg, K., and Knof, L. Die Lignane des Fichtenholzes. Chem. Ber., 90: 2857-2869, 1957.
19. Barton, G. M., and Gardner, J. A. F. The occurrence of matairesinol in mountain hemlock (Tsuga mertensiana), western hemlock (Tsuga heterophylla) and balsam (Abies amabilis). J. Org. Chem., 27: 322-323, 1962.
20. Tatematsu, H., Kurokawa, M., Niwa, M., and Hirata, Y. Piscicidal constituents of Stellera chamaejasme L. II. Chem Pharm Bull. (Tokyo), 32: 1612-1613, 1984.
21. Valentín-Blasini, L., Blount, B. C., Rogers, H. S., and Needham, L. HPLC-MS/MS method for the measurement of seven phytoestrogens in human serum and urine. J. Exposure Analysis and Environ. Epidemiol., 10: 799-807, 2000. (Pubitemid 32038564)
22. Archer, F. L., and Orlando, R. A. Morphology, natural history and enzyme patterns in mammary tumors of the rat induced by 7, 12-dimethylbenz(a) anthracene. Cancer Res., 28: 217-224, 1968.
23. Li, X., Nokkala, E., Yan, W., Streng, T., Saarinen, N., Wärri, A., Huhtaniemi, I., Santti, R., Mäkelä, S., and Poutanen, M. Altered structure function of reproductive organs in transgenic male mice overexpressing human aromatase. Endocrinology, 142: 2435-2442, 2001. (Pubitemid 32475760)
24. Waters, A. P., and Knowler, J. T. Effect of a lignan (HPMF) on RNA synthesis in the rat uterus. J. Reprod. Fertil., 66: 379-381, 1982. (Pubitemid 13252657)
25. Saarinen, N. M., Wärri, A., Mäkelä, S. I., Eckerman, C., Reunanen, M., Ahotupa, M., Salmi, S. M., Franke, A. A., Knagas, L., and Santti, R. Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies). Nutr. Cancer, 36: 207-216, 2000. (Pubitemid 30437042)
26. Pearson, O. H., Llerena, O., Llerena, L., Mollina, A., and Butler, T. Prolactin-dependent rat mammary cancer: a model for man? Trans. Ass. Am. Phys., 82: 225-238, 1969.
27. Jordan, V. C. Laboratory models of breast cancer to aid the elucidation of antiestrogen action. J. Lab. Clin. Med., 109: 267-277, 1987. (Pubitemid 17034034)
28. Houjou, T., Wada, T., and Yasutomi, M. Antitumor and endocrine effect of an aromatase inhibitor (CGS 16949A) on DMBA-induced rat mammary tumor. Clin. Ther., 15: 137-147, 1993. (Pubitemid 23102364)
29. Zaccheo, T., Giudici, D., Ornati, G., Panzeri, A., and di Salle, E. Comparison of the effects of the irreversible aromatase inhibitor exemestane with atamestane and MDL 18962 in rats with DMBA-induced mammary tumours. Eur. J. Cancer, 27: 1145-1150, 1991.
30. Tominaga, T., Yoshida, Y., Shimozuma, K., Hayashi, K., and Kosaki, G. Effect of CGS 16949A plus tamoxifen on induced mammary tumours in rats. Eur. J. Cancer, 26: 600-603, 1990. (Pubitemid 20259339)
31. Hutchins, A. M., Martini, M. C., Olson, B. A., Thomas, W., and Slavin, J. L. Flaxseed consumption influences endogenous hormone concentrations in postmenopausal women. Nutr. Cancer, 39: 58-65, 2001. (Pubitemid 32880949)
32. McCormick, D. L., Major, N., and Moon, R. C. Inhibition of 7, 12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis by concomitant or postcarcinogen antioxidant exposure. Cancer Res., 44: 2858-2863, 1984. (Pubitemid 14083249)
33. Cohen, L. A., Polansky, M., Furuya, K., Reddy, M., Berke, B., and Weisburger, J. H. Inhibition of chemically induced mammary carcinogenesis in rats by short-term exposure to butylated hydroxytoluene (BHT): interrelationships among BHT concentration, carcinogen dose, and diet. J. Cell. Biochem. Suppl., 72: 165-174, 1984. (Pubitemid 14159244)
34. Duncan, A. M., Merz-Demlow, B. E., Xu, X., Phipps, W. R., and Kurzer, M. S. Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer. Cancer Epidemiol. Biomark. Prev., 9: 581-586, 2000. (Pubitemid 30396180)