Cellular immunotherapy: Antigen recognition is just the beginning

Springer Seminars in Immunopathology

Volumn 27, Issue 1, 2005, Pages 119-127

  Chen, Daniel S ^a   Davis, Mark M ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

CD8+ T cell function; Cellular microarray; Effector cytokines; T cell assays; Tumor immunology

Indexed keywords

CANCER VACCINE; TUMOR ANTIGEN;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; CELL MOTILITY; CELLULAR IMMUNITY; DRUG TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, NEOPLASM; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HUMANS; IMMUNOTHERAPY, ADOPTIVE; NEOPLASMS;

EID: 21344452606     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00281-005-0200-z     Document Type: Review

References (43)

1. Altman JD, Moss PA, Goulder PJ, et al (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94
2. Antonia S, Mule JJ, Weber JS (2004) Current developments of immunotherapy in the clinic. Curr Opin Immunol 16:130
3. Applegate KG, Balch CM, Pellis NR (1990) In vitro migration of lymphocytes through collagent matrix: arrested locomotion in tumor-infiltrating lymphocytes. Cancer Res 50:7153
4. Bachmann MF, Barner M, Viola A, et al (1999) Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection. Eur J Immunol 29:291
5. + regulatory T cells. Semin Immunol 16:89
6. Bernabei P, Coccia EM, Rigamonti L, et al (2001) Interferon-gamma receptor 2 expression as the deciding factor in human T, B and myeloid cell proliferation or death. J Leukoc Biol 70:950
7. Beutler BA (1999) The role of tumor necrosis factor in health and disease. J Rheumatol Suppl 57:16
8. Biron CA (2001) Interferons alpha and beta as immune regulators - a new look. Immunity 14:661
9. 8a. Chen DS, Soen Y, Davis MM, Brown PO (2004) Functional and molecular profiling of heterogeneous tumor samples using a novel cellular microarray. Journal of Clinical Oncology 22:9507
10. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860
11. Davis MM, Boniface JJ, Reich Z (1998) Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol 16:523
12. Eklund JW, Kuzel TM (2004) A review of recent findings involving interleukin-2-based cancer therapy. Curr Opin Oncol 16:542
13. Groettrup M, Khan S, Schwarz K, et al (2001) Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why? Biochimie 83:367
14. Hecht I, Cahalon L, Hershkoviz R, et al (2003) Heterologous desensitization of T cell function by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis. Int Immunol 15:29
15. Horwitz DA, Zheng SG, Gray JD, et al (2004) Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease. Semin Immunol 16:135
16. Kwon B, Kim BS, Cho HR, et al (2003) Involvement of tumor necrosis factor receptor superfamily (TNFRSF) members in the pathogenesis of inflammatory diseases. Exp Mol Med 35:8
17. Lee PP, Yee C, Savage PA, et al (1999) Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med 5:677
18. Lee P, Wang F, Kuniyoshi J, et al (2001) Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma. J Clin Oncol 19:3836
19. Lehner PJ, Cresswell P (2004) Recent developments in M class I-mediated antigen presentation. Curr Opin Immunol 16:82
20. Lejeune FJ, Ruegg C, Lienard D (1998) Clinical applications of TNF-alpha in cancer. Curr Opin Immunol 10:573
21. + T cells specific to a single viral epitope. J Immunol 165:6214
22. Malek TR, Bayer AL (2004) Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4:665
23. Mestas J, Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172:2731
24. Mills KH (2004) Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol 4:841
25. Muller WJ, Sinn E, Pattengale PK, et al (1988) Single-step induction of mammary adenocarcrnoma in transgenic mice bearing the activated c-neu oncogene. Cell 54:105
26. Naka T, Nishimoto N, Kishimoto T (2002) The paradigm of IL-6: from basic science to medicine. Arthritis Res 4 Suppl 3: S233
27. Nandi A, Estess P, Siegelman M (2004) Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation. Immunity 20:455
28. Negulescu PA, Krasieva TB, Khan A, et al (1996) Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4:421
29. Paul WE (2003) Fundamental Immunology. Lippincott, Williams & Wilkins, Philadelphia
30. Prevost-Blondel A, Roth E, Rosenthal FM, et al (2000) Crucial role of TNF-alpha in CD8 T cell-mediated elimination of 3LL-A9 Lew lung carcinoma cells in vivo. J Immunol 164:3645
31. Purbhoo MA, Irvine DJ, Huppa JB, et al (2004) T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol 5:524
32. Raja SM, Metkar SS, Froelich CJ (2003) Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol 15:528
33. Rosenberg SA (2001) Progress in human tumour immunology and immunotherapy. Nature 411:380
34. Rosenwasser LJ (1998) Biologic activities of IL-1 and its role in human disease. J Allergy Clin Immunol 102:344
35. Schmittel A, Keilholz U, Thiel E, et al (2000) Quantification of tumor-specific T lymphocytes with the ELISPOT assay. J Immunother 23:289
36. Schroder K, Hertzog PJ, Ravasi T, et al (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163
37. Snapper CM, Paul WE (1987) Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944
38. Soen Y, Chen DS, Kraft DL, et al (2003) Detection and characterization of cellular immune responses using peptide-MHC microarrays. PLoS Biol 1:E65
39. 37a. Soen Y, Chen DS, Stuge T, et al (2003) A novel cellular microarray identifies functional deficiencies in tumor-specific T cell responses. Journal of Clinical Oncology 22:2510
40. Taams LS, Eden W van, Wauben MH (1999) Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactions. Eur J Immunol 29:1543
41. Tracey KJ, Beutler B, Lowry SF, et al (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234:470
42. Whiteside TL, Zhao Y, Tsukishiro T, et al (2003) Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell responses to a dendritic cell-based multipeptide vaccine in patients with melanoma. Clin Cancer Res 9:641
43. Zippelius A, Batard P, Rubio-Godoy V, et al (2004) Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res 64:2865