메뉴 건너뛰기




Volumn 16, Issue 2, 2004, Pages 130-136

Current developments of immunotherapy in the clinic

Author keywords

Complete response; CR; CTL; CTL antigen 4; CTLA 4; Cytotoxic T lymphocyte; GM CSF; Granulocyte macrophage colony stimulating factor; Heat shock protein; HLA; Hsp; Human leukocyte antigen; IFN; IL; Interferon; Interleukin; MAGE; MART 1; Melanoma antigen

Indexed keywords

ADENOVIRUS VECTOR; BCG VACCINE; CANCER VACCINE; CANVAXIN; CARCINOEMBRYONIC ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLT3 LIGAND; FREUND ADJUVANT; GLYCOPROTEIN GP 100; GLYCOPROTEIN GP 96; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MELACINE; MELAN A; MELANOMA ANTIGEN; MELANOMA ANTIGEN 1; MELANOMA ANTIGEN 3; MELANOMA ANTIGEN A1; MONOPHENOL MONOOXYGENASE; OLIGONUCLEOTIDE; PROTEIN ANTIBODY; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 4; RECOMBINANT PROTEIN; TUMOR VACCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 1542351347     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.01.012     Document Type: Review
Times cited : (67)

References (68)
  • 1
    • 0031713904 scopus 로고    scopus 로고
    • Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving ployvalent melanoma cell vaccine
    • Hsueh E.C., Gupta R.K., Qi K., Morton D.L. Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving ployvalent melanoma cell vaccine. J Clin Oncol. 16:1998;2913-2920.
    • (1998) J Clin Oncol , vol.16 , pp. 2913-2920
    • Hsueh, E.C.1    Gupta, R.K.2    Qi, K.3    Morton, D.L.4
  • 2
    • 0035985655 scopus 로고    scopus 로고
    • Cancer vaccines, a critical review-part I
    • Mitchell M.S. Cancer vaccines, a critical review-part I. Curr Opin Investig Drugs. 3:2002;140-149.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 140-149
    • Mitchell, M.S.1
  • 3
    • 0037089672 scopus 로고    scopus 로고
    • Southwest Oncology Group. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Impact of HLA class I antigen expression on outcome
    • Sosman J.A., Unger J.M., Liu P.Y., Flaherty L.E., Park M.S., Kempf R.A., Thompson J.A., Terasaki P.I., Sondak V.K. Southwest Oncology Group. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome. J Clin Oncol. 20:2002;2067-2075.
    • (2002) J Clin Oncol , vol.20 , pp. 2067-2075
    • Sosman, J.A.1    Unger, J.M.2    Liu, P.Y.3    Flaherty, L.E.4    Park, M.S.5    Kempf, R.A.6    Thompson, J.A.7    Terasaki, P.I.8    Sondak, V.K.9
  • 4
    • 0037089687 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Overall results of a randomized trial of the Southwest Oncology Group
    • Sondak V.K., Liu P.Y., Tuthill R.J., Kempf R.A., Unger J.M., Sosman J.A., Thompson J.A., Weiss G.R., Redman B.G., Jakowatz J.G.et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: overall results of a randomized trial of the Southwest Oncology Group. J Clin Oncol. 20:2002;2058-2066.
    • (2002) J Clin Oncol , vol.20 , pp. 2058-2066
    • Sondak, V.K.1    Liu, P.Y.2    Tuthill, R.J.3    Kempf, R.A.4    Unger, J.M.5    Sosman, J.A.6    Thompson, J.A.7    Weiss, G.R.8    Redman, B.G.9    Jakowatz, J.G.10
  • 6
    • 0141576738 scopus 로고    scopus 로고
    • Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    • Soiffer R., Hodi F.S., Haluska F., Jung K., Gillessen S., Singer S., Tanabe K., Duda R., Mentzer S., Jaklitsch M.et al. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol. 21:2003;3343-3350.
    • (2003) J Clin Oncol , vol.21 , pp. 3343-3350
    • Soiffer, R.1    Hodi, F.S.2    Haluska, F.3    Jung, K.4    Gillessen, S.5    Singer, S.6    Tanabe, K.7    Duda, R.8    Mentzer, S.9    Jaklitsch, M.10
  • 7
    • 0037441842 scopus 로고    scopus 로고
    • Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    • Salgia R., Lynch T., Skarin A., Lucca J., Lynch C., Jung K., Hodi F.S., Jaklitsch M., Mentzer S., Swanson S.et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol. 21:2003;624-630.
    • (2003) J Clin Oncol , vol.21 , pp. 624-630
    • Salgia, R.1    Lynch, T.2    Skarin, A.3    Lucca, J.4    Lynch, C.5    Jung, K.6    Hodi, F.S.7    Jaklitsch, M.8    Mentzer, S.9    Swanson, S.10
  • 8
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A phase I trial of safety and immune activation
    • Jaffee E.M., Hruban R.H., Biedrzycki B., Laheru D., Schepers K., Sauter P.R., Goemann M., Coleman J., Grochow L., Donehower R.C.et al. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol. 19:2001;145-156.
    • (2001) J Clin Oncol , vol.19 , pp. 145-156
    • Jaffee, E.M.1    Hruban, R.H.2    Biedrzycki, B.3    Laheru, D.4    Schepers, K.5    Sauter, P.R.6    Goemann, M.7    Coleman, J.8    Grochow, L.9    Donehower, R.C.10
  • 9
    • 0037108696 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings
    • This is the first evidence that heat shock proteins are immunogenic in humans and can induce anti-tumor responses.
    • Belli F., Testori A., Rivoltini L., Maio M., Andreola G., Sertoli M.R., Gallino G., Piris A., Cattelan A., Lazzari I.et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol. 20:2002;4169-4180 This is the first evidence that heat shock proteins are immunogenic in humans and can induce anti-tumor responses.
    • (2002) J Clin Oncol , vol.20 , pp. 4169-4180
    • Belli, F.1    Testori, A.2    Rivoltini, L.3    Maio, M.4    Andreola, G.5    Sertoli, M.R.6    Gallino, G.7    Piris, A.8    Cattelan, A.9    Lazzari, I.10
  • 13
    • 0030000146 scopus 로고    scopus 로고
    • Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variants in vivo
    • Jager E., Ringhoffer M., Karbach J., Arand M., Oesch F., Knuth A. Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo. Int J Cancer. 66:1996;470-476.
    • (1996) Int J Cancer , vol.66 , pp. 470-476
    • Jager, E.1    Ringhoffer, M.2    Karbach, J.3    Arand, M.4    Oesch, F.5    Knuth, A.6
  • 15
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • The establishment of a new paradigm for the association of clinical autoimmunity induced by a biological compound and anti-tumor response in melanoma.
    • Phan G.Q., Yang J.C., Sherry R.M., Hwu P., Topalian S.L., Schwartzentruber D.J., Restifo N.P., Haworth L.R., Seipp C.A., Freezer L.J.et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA. 100:2003;8372-8377 The establishment of a new paradigm for the association of clinical autoimmunity induced by a biological compound and anti-tumor response in melanoma.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6    Restifo, N.P.7    Haworth, L.R.8    Seipp, C.A.9    Freezer, L.J.10
  • 16
    • 0642311904 scopus 로고    scopus 로고
    • Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells
    • Slingluff C.L. Jr., Petroni G.R., Yamshchikov G.V., Barnd D.L., Eastham S., Galavotti H., Patterson J.W., Deacon D.H., Hibbitts S., Teates D.et al. Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells. J Clin Oncol. 21:2003;4016-4026.
    • (2003) J Clin Oncol , vol.21 , pp. 4016-4026
    • Slingluff, C.L.Jr.1    Petroni, G.R.2    Yamshchikov, G.V.3    Barnd, D.L.4    Eastham, S.5    Galavotti, H.6    Patterson, J.W.7    Deacon, D.H.8    Hibbitts, S.9    Teates, D.10
  • 17
    • 0037431558 scopus 로고    scopus 로고
    • Clinical and immunological evaluation of patients with metastatic melanoma undergoing immunization with the HLA-Cw*0702-associated epitope MAGE-A12:170-178
    • Bettinotti M.P., Panelli M.C., Ruppe E., Mocellin S., Phan G.Q., White D.E., Marincola F.M. Clinical and immunological evaluation of patients with metastatic melanoma undergoing immunization with the HLA-Cw*0702- associated epitope MAGE-A12:170-178. Int J Cancer. 105:2003;210-216.
    • (2003) Int J Cancer , vol.105 , pp. 210-216
    • Bettinotti, M.P.1    Panelli, M.C.2    Ruppe, E.3    Mocellin, S.4    Phan, G.Q.5    White, D.E.6    Marincola, F.M.7
  • 18
    • 3042780034 scopus 로고    scopus 로고
    • Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenza peptides in subjects with advanced malignant melanoma
    • Cebon J., Jager E., Shackleton M.J., Gibbs P., Davis I.D., Hopkins W., Gibbs S., Chen Q., Karbach J., Jackson H.et al. Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenza peptides in subjects with advanced malignant melanoma. Cancer Immun. 3:2003;7-17.
    • (2003) Cancer Immun , vol.3 , pp. 7-17
    • Cebon, J.1    Jager, E.2    Shackleton, M.J.3    Gibbs, P.4    Davis, I.D.5    Hopkins, W.6    Gibbs, S.7    Chen, Q.8    Karbach, J.9    Jackson, H.10
  • 20
    • 0033934224 scopus 로고    scopus 로고
    • Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100
    • Panelli M.C., Wunderlich J., Jeffries J., Wang E., Mixon A., Rosenberg S.A., Marincola F.M. Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. J Immunother. 23:2000;487-498.
    • (2000) J Immunother , vol.23 , pp. 487-498
    • Panelli, M.C.1    Wunderlich, J.2    Jeffries, J.3    Wang, E.4    Mixon, A.5    Rosenberg, S.A.6    Marincola, F.M.7
  • 22
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with Mage-3A1 peptide-pulsed mature monocyte-derived dendritic cells expands specific cytotoxic T-cells and induces regression of some metastases in advanced stage IV melanoma
    • Thurner B., Haendle I., Roder C., Dieckmann D., Keikavoussi P., Jonuleit H., Bender A., Maczek C., Schreiner D., von den Dreisch P.et al. Vaccination with Mage-3A1 peptide-pulsed mature monocyte-derived dendritic cells expands specific cytotoxic T-cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med. 190:1999;1669-1678.
    • (1999) J Exp Med , vol.190 , pp. 1669-1678
    • Thurner, B.1    Haendle, I.2    Roder, C.3    Dieckmann, D.4    Keikavoussi, P.5    Jonuleit, H.6    Bender, A.7    MacZek, C.8    Schreiner, D.9    Von Den Dreisch, P.10
  • 23
    • 0034181264 scopus 로고    scopus 로고
    • Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells
    • Mackensen A., Herbst B., Chen J.L., Kohler G., Noppen C., Herr W., Spagnoli G.C., Cerundolo V., Lindemann A. Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells. Int J Cancer. 86:2000;385-392.
    • (2000) Int J Cancer , vol.86 , pp. 385-392
    • MacKensen, A.1    Herbst, B.2    Chen, J.L.3    Kohler, G.4    Noppen, C.5    Herr, W.6    Spagnoli, G.C.7    Cerundolo, V.8    Lindemann, A.9
  • 26
    • 0034734639 scopus 로고    scopus 로고
    • Treatment of solid tumors in children with tumour-lysate-pulsed dendritic cells
    • Geiger J., Hutchinson R., Hohenkirk L., McKenna E., Chang A., Mulé J.J. Treatment of solid tumors in children with tumour-lysate- pulsed dendritic cells. Lancet. 356:2000;1163-1164.
    • (2000) Lancet , vol.356 , pp. 1163-1164
    • Geiger, J.1    Hutchinson, R.2    Hohenkirk, L.3    McKenna, E.4    Chang, A.5    Mulé, J.J.6
  • 28
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee C., Thompson J.A., Byrd D., Riddell S.R., Roche P., Celis E., Greenberg P.D. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci USA. 99:2002;16168-16173.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3    Riddell, S.R.4    Roche, P.5    Celis, E.6    Greenberg, P.D.7
  • 30
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • This is the first demonstration that lymphoid depletion followed by adoptive cell transfer in the face of homeostatic lymphoid proliferation augment anti-tumor T-cell responses.
    • Dudley M.E., Wunderlich J.R., Robbins P.F., Yang J.C., Hwu P., Schwartzentruber D.J., Topalian S.L., Sherry R., Restifo N.P., Hubicki A.M.et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 298:2002;850-854 This is the first demonstration that lymphoid depletion followed by adoptive cell transfer in the face of homeostatic lymphoid proliferation augment anti-tumor T-cell responses.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3    Yang, J.C.4    Hwu, P.5    Schwartzentruber, D.J.6    Topalian, S.L.7    Sherry, R.8    Restifo, N.P.9    Hubicki, A.M.10
  • 32
    • 0033846635 scopus 로고    scopus 로고
    • The future of interleukin-2: Enhancing therapeutic anticancer vaccines
    • Overwijk W.W., Theoret M.R., Restifo N.P. The future of interleukin-2: enhancing therapeutic anticancer vaccines. Cancer J Sci Am. 6(Suppl 1):2000;S76-S80.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL. 1 , pp. 76-S80
    • Overwijk, W.W.1    Theoret, M.R.2    Restifo, N.P.3
  • 33
    • 0033514937 scopus 로고    scopus 로고
    • Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines
    • Shimizu K., Fields R.C., Giedlin M., Mule J. Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines. Proc Natl Acad Sci USA. 96:1999;2268-2273.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2268-2273
    • Shimizu, K.1    Fields, R.C.2    Giedlin, M.3    Mule, J.4
  • 36
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 3:2003;133-146.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 38
    • 0028944328 scopus 로고
    • Influence of interleukin 12 on p53 peptide vaccination against established Meth a sarcoma
    • Noguchi Y., Richards E.C., Chen Y.T., Old L.J. Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma. Proc Natl Acad Sci USA. 92:1995;2219-2223.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2219-2223
    • Noguchi, Y.1    Richards, E.C.2    Chen, Y.T.3    Old, L.J.4
  • 39
    • 0033579865 scopus 로고    scopus 로고
    • Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12
    • Fallarino F., Uyttenhove C., Boon T., Gajewski T.F. Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12. Int J Cancer. 80:1999;324-333.
    • (1999) Int J Cancer , vol.80 , pp. 324-333
    • Fallarino, F.1    Uyttenhove, C.2    Boon, T.3    Gajewski, T.F.4
  • 40
    • 0037811736 scopus 로고    scopus 로고
    • Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
    • Peterson A.C., Harlin H., Gajewski T.F. Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J Clin Oncol. 21:2003;2342-2348.
    • (2003) J Clin Oncol , vol.21 , pp. 2342-2348
    • Peterson, A.C.1    Harlin, H.2    Gajewski, T.F.3
  • 42
    • 0036093713 scopus 로고    scopus 로고
    • Flt-3 ligand and sequential FL/interleukin-2 in patients with metastatic renal carcinoma: Clinical and biologic activity
    • Rini B.I., Paintal A., Vogelzang N.J., Gajewski T.F., Stadler W.M. Flt-3 ligand and sequential FL/interleukin-2 in patients with metastatic renal carcinoma: clinical and biologic activity. J Immunother. 25:2002;269-277.
    • (2002) J Immunother , vol.25 , pp. 269-277
    • Rini, B.I.1    Paintal, A.2    Vogelzang, N.J.3    Gajewski, T.F.4    Stadler, W.M.5
  • 43
    • 0037089223 scopus 로고    scopus 로고
    • Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers
    • Disis M.L., Rinn K., Knutson K.L., Davis D., Caron D., dela Rosa C., Schiffman K. Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers. Blood. 99:2002;2845-2850.
    • (2002) Blood , vol.99 , pp. 2845-2850
    • Disis, M.L.1    Rinn, K.2    Knutson, K.L.3    Davis, D.4    Caron, D.5    Dela Rosa, C.6    Schiffman, K.7
  • 44
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal I.S., Flavell R.A. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 16:1998;111-135.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 45
    • 0038491296 scopus 로고    scopus 로고
    • Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation
    • Delamarre L., Holcombe H., Mellman I. Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med. 198:2003;111-122.
    • (2003) J Exp Med , vol.198 , pp. 111-122
    • Delamarre, L.1    Holcombe, H.2    Mellman, I.3
  • 47
    • 0034662607 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells
    • Brossart P., Zobywalski A., Grunebach F., Behnke L., Stuhler G., Reichardt V.L., Kanz L., Brugger W. Tumor necrosis factor alpha and CD40 ligand antagonize the inhibitory effects of interleukin 10 on T-cell stimulatory capacity of dendritic cells. Cancer Res. 60:2000;4485-4492.
    • (2000) Cancer Res , vol.60 , pp. 4485-4492
    • Brossart, P.1    Zobywalski, A.2    Grunebach, F.3    Behnke, L.4    Stuhler, G.5    Reichardt, V.L.6    Kanz, L.7    Brugger, W.8
  • 48
    • 0033941461 scopus 로고    scopus 로고
    • Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins
    • Pirtskhalaishvili G., Shurin G.V., Esche C., Cai Q., Salup R.R., Bykovskaia S.N., Lotze M.T., Shurin M.R. Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins. Br J Cancer. 83:2000;506-513.
    • (2000) Br J Cancer , vol.83 , pp. 506-513
    • Pirtskhalaishvili, G.1    Shurin, G.V.2    Esche, C.3    Cai, Q.4    Salup, R.R.5    Bykovskaia, S.N.6    Lotze, M.T.7    Shurin, M.R.8
  • 50
    • 0036660415 scopus 로고    scopus 로고
    • Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cells
    • Dotti G., Savoldo B., Yotnda P., Rill D., Brenner M.K. Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cells. Blood. 100:2002;200-207.
    • (2002) Blood , vol.100 , pp. 200-207
    • Dotti, G.1    Savoldo, B.2    Yotnda, P.3    Rill, D.4    Brenner, M.K.5
  • 52
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol. 20:2002;709-760.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 53
    • 0038717560 scopus 로고    scopus 로고
    • CpG motifs: The active ingredient in bacterial extracts?
    • Krieg A.M. CpG motifs: the active ingredient in bacterial extracts? Nat Med. 9:2003;831-835.
    • (2003) Nat Med , vol.9 , pp. 831-835
    • Krieg, A.M.1
  • 55
    • 0032531036 scopus 로고    scopus 로고
    • Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
    • Jakob T., Walker P.S., Krieg A.M., Udey M.C., Vogel J.C. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol. 161:1998;3042-3049.
    • (1998) J Immunol , vol.161 , pp. 3042-3049
    • Jakob, T.1    Walker, P.S.2    Krieg, A.M.3    Udey, M.C.4    Vogel, J.C.5
  • 56
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T., Koch E.S., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W., Wagner H. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol. 28:1998;2045-2054.
    • (1998) Eur J Immunol , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6    Wagner, H.7
  • 57
    • 0033529891 scopus 로고    scopus 로고
    • CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
    • Hartmann G., Weiner G.J., Krieg A.M. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc Natl Acad Sci USA. 96:1999;9305-9310.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9305-9310
    • Hartmann, G.1    Weiner, G.J.2    Krieg, A.M.3
  • 58
    • 0034547842 scopus 로고    scopus 로고
    • Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate- guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo
    • Brunner C., Seiderer J., Schlamp A., Bidlingmaier M., Eigler A., Haimerl W., Lehr H.A., Krieg A.M., Hartmann G., Endres S. Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo. J Immunol. 165:2000;6278-6286.
    • (2000) J Immunol , vol.165 , pp. 6278-6286
    • Brunner, C.1    Seiderer, J.2    Schlamp, A.3    Bidlingmaier, M.4    Eigler, A.5    Haimerl, W.6    Lehr, H.A.7    Krieg, A.M.8    Hartmann, G.9    Endres, S.10
  • 59
    • 0037439696 scopus 로고    scopus 로고
    • CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma
    • Sandler A.D., Chihara H., Kobayashi G., Zhu X., Miller M.A., Scott D.L., Krieg A.M. CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma. Cancer Res. 63:2003;394-399.
    • (2003) Cancer Res , vol.63 , pp. 394-399
    • Sandler, A.D.1    Chihara, H.2    Kobayashi, G.3    Zhu, X.4    Miller, M.A.5    Scott, D.L.6    Krieg, A.M.7
  • 60
    • 0042674185 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines
    • Rieger R., Kipps T.J. CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines. Cancer Res. 63:2003;4128-4135.
    • (2003) Cancer Res , vol.63 , pp. 4128-4135
    • Rieger, R.1    Kipps, T.J.2
  • 61
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila E., Kennedy R., Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 63:2003;3281-3288.
    • (2003) Cancer Res , vol.63 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 62
    • 0037097633 scopus 로고    scopus 로고
    • Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity
    • Stern B.V., Boehm B.O., Tary-Lehmann M. Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity. J Immunol. 168:2002;6099-6105.
    • (2002) J Immunol , vol.168 , pp. 6099-6105
    • Stern, B.V.1    Boehm, B.O.2    Tary-Lehmann, M.3
  • 63
    • 0036493558 scopus 로고    scopus 로고
    • In vivo manipulation of dendritic cells to induce therapeutic immunity
    • Merad M., Sugie T., Engleman E.G., Fong L. In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood. 99:2002;1676-1682.
    • (2002) Blood , vol.99 , pp. 1676-1682
    • Merad, M.1    Sugie, T.2    Engleman, E.G.3    Fong, L.4
  • 64
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin S.A., Van Nest G., Smith B., Abtahi S., Whiley H., Eiden J.J. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine. 21:2003;2461-2467.
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 65
    • 0038683055 scopus 로고    scopus 로고
    • Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGE-3 protein in patients with MAGE-3 positive tumors
    • van Ojik H. Phase I/II study with CpG 7909 as adjuvant to vaccination with MAGE-3 protein in patients with MAGE-3 positive tumors. Ann Oncol. 13:2002;157.
    • (2002) Ann Oncol , vol.13 , pp. 157
    • Van Ojik, H.1
  • 66
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas T.L., Bluestone J.A. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:1994;405-413.
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1    Bluestone, J.A.2
  • 68
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • This is the first clinical demonstration that CTLA-4 blockade can elicit measurable immunological effects in melanoma patients.
    • Hodi F.S., Mihm M.C., Soiffer R.J., Haluska F.G., Butler M., Seiden M.V., Davis T., Henry-Spires R., MacRae S., Willman A.et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA. 100:2003;4712-4717 This is the first clinical demonstration that CTLA-4 blockade can elicit measurable immunological effects in melanoma patients.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3    Haluska, F.G.4    Butler, M.5    Seiden, M.V.6    Davis, T.7    Henry-Spires, R.8    MacRae, S.9    Willman, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.