T cell-mediated immune responses in human newborns: Ready to learn?

Clinical and Experimental Immunology

Volumn 141, Issue 1, 2005, Pages 10-18

  Marchant, Arnaud ^a,b   Goldman, M ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Institute for Medical Immunology   (Belgium)

Author keywords

Dendritic cells; Human studies; Paediatric; T cells; Vaccines

Indexed keywords

ALPHA INTERFERON; BCG VACCINE; CD27 ANTIGEN; CD28 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD45 ANTIGEN; CD8 ANTIGEN; CYTOMEGALOVIRUS VACCINE; GAMMA INTERFERON; HEPATITIS B VACCINE; HERPES SIMPLEX VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; MEASLES VACCINE; ORAL POLIOMYELITIS VACCINE; PERTUSSIS TOXIN; PERTUSSIS VACCINE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR NFAT; VACCINE;

CELLULAR IMMUNITY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE REARRANGEMENT; HEPATITIS B VIRUS; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGICAL MEMORY; MYCOBACTERIUM TUBERCULOSIS; NEWBORN; NEWBORN INFECTION; PLACENTAL TRANSFER; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; SYSTEMATIC REVIEW; TH1 CELL; TH2 CELL; TRYPANOSOMA CRUZI; VACCINATION;

DENDRITIC CELLS; HUMANS; IMMUNITY, CELLULAR; INFANT, NEWBORN; INFECTION; T-LYMPHOCYTES; VACCINES;

EID: 21344451855     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02799.x     Document Type: Review

References (112)

1. Zinkernagel RM. Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med 2001; 345:1331-5.
2. Rassin DK, Garofalo RP, Ogra PL. Human milk. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and the Newborn Infant. Philadelphia: W.B. Saunders Company, 2001:169-204.
3. Marchant A, Newport M. Prevention of infectious diseases by neonatal and early infantile immunization: prospects for the new millennium. Curr Opin Infect Dis 2000; 13:241-6.
4. Siegrist CA. Neonatal and early life vaccinology. Vaccine 2001; 19:3331-46.
5. Goulder PJ, Jeena P, Tudor-Williams G, Burchett S. Paediatric HIV infection: correlates of protective immunity and global perspectives in prevention and management. Br Med J 2001; 58:89-108.
6. Stagno S. Cytomegalovirus. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and the Newborn Infant. Philadelphia: W.B. Saunders Company, 2001:389-424.
7. Arvin A, Whitley. Herpes simplex virus infections. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and the Newborn Infant. Philadelphia: W.B. Saunders Company, 2001:425-46.
8. Mahoney FJ, Kane. Hepatitis B vaccine. In: Plotkin SA, Orenstein WA, eds. Vaccines. Philadelphia: WB. Saunders Company, 1999:158-82.
9. Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 2004; 4:553-64.
10. Schonland SO, Zimmer JK, Lopez-Benitez CM, Widmann T, Ramin KD, Goronzy JJ, Weyand CM. Homeostatic control of T-cell generation in neonates. Blood 2003; 102:1428-34.
11. Hassan J, Reen DJ. Human recent thymic emigrants - identification, expansion, and survival characteristics. J Immunol 2001; 167:1970-6.
12. Szabolcs P, Park KD, Reese M, Marti L, Broadwater G, Kurtzberg J. Coexistent naive phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. Exp Hematol 2003; 31:708-14.
13. Hassan J, Reen DJ. IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur J Immunol 1998; 28:3057-65.
14. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998; 161:5909-17.
15. Hazenberg MD, Otto SA, van Rossum AM et al. Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1. Blood 2004; 104:3513-9.
16. Fukui T, Katamura K, Abe N, Kiyomasu T, Iio J, Ueno H, Mayumi M, Furusho K. IL-7 induces proliferation, variable cytokine-producing ability and IL-2 responsiveness in naive CD4+ T-cells from human cord blood. Immunol Lett 1997; 59:21-8.
17. Webb LM, Foxwell BM, Feldmann M. Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool. Immunology 1999; 98:400-5.
18. Freeden-Jeffry U, Solvason N, Howard M, Murray R. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 1997; 7:147-54.
19. O'Neill RM, Hassan J, Reen DJ. IL-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death. J Immunol 2003; 170:4524-31.
20. Cookson S, Reen D. IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells. Blood 2003; 102:2195-7.
21. Min B, McHugh R, Sempowski G D, Mackall C, Foucras G, Paul WE. Neonates support lymphopenia-induced proliferation. Immunity 2003; 18:131-40.
22. Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mosmann TR. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells. J Immunol 1996; 156:653-62.
23. Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med 1996; 184:539-48.
24. Szekeres-Bartho J, Faust Z, Varga P, Szereday L, Kelemen K. The immunological pregnancy protective effect of progesterone is manifested via controlling cytokine production. Am J Reprod Immunol 1996; 35:348-51.
25. White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. J Immunol 2002; 168:2820-7.
26. Ohshima Y, Delespesse G. T cell-derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen-primed naive human CD4 T cells. J Immunol 1997; 158:629-36.
27. Mingari MC, Maggi E, Cambiaggi A, Annunziato F, Schiavetti F, Manetti R, Moretta L, Romagnani S. Development in vitro of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous interleukin-12 is required for priming thymocytes to produce both Th1 cytokines and interleukin-10. Eur J Immunol 1996; 26:1083-7.
28. Delespesse G, Yang LP, Ohshima Y, Demeure C, Shu U, Byun DG, Sarfati M. Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors. Vaccine 1998; 16:1415-9.
29. Durandy A, De Saint BG, Lisowska-Grospierre B, Gauchat JF, Forveille M, Kroczek RA, Bonnefoy JY, Fischer A. Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns. J Immunol 1995; 154:1560-8.
30. Nonoyama S, Penix LA, Edwards CP, Lewis DB, Ito S, Aruffo A, Wilson C B, Ochs HD. Diminished expression of CD40 ligand by activated neonatal T cells. J Clin Invest 1995; 95:66-75.
31. Fuleihan R, Ahern D, Geha RS. Decreased expression of the ligand for CD40 in newborn lymphocytes. Eur J Immunol 1994; 24:1925-8.
32. Brugnoni DP, Airo D, Graf M et al. Ugazio, and. Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn. Eur J Immunol 1994; 24:1919-24.
33. Jullien P, Cron RQ, Dabbagh K, Cleary A, Chen L, Tran P, Stepick-Biek P, Lewis DB. Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation. Int Immunol 2003; 15:1461-72.
34. Splawski JB, Nishioka J, Nishioka Y, Lipsky PE. CD40 ligand is expressed and functional on activated neonatal T cells. J Immunol 1996; 156:119-27.
35. Suarez A, Mozo L, Gayo A, Simo A, Gutierrez C. Induction of functional CD154 (CD40 ligand) in neonatal T cells by cAMP-elevating agents. Immunology 2000; 100:432-40.
36. Kadereit S, Mohammad SF, Miller RE et al. Reduced NFAT1 protein expression in human umbilical cord blood T lymphocytes. Blood 1999; 94:3101-7.
37. Kaminski BA, Kadereit S, Miller RE et al. Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation. Blood 2003; 102:4608-17.
38. O'Neill RM, Reen DJ. Equivalent functional nuclear factor of activated T cell 1 mRNA and protein expression in cord blood and adult T cells. Transplantation 2003; 76:1526-8.
39. Lee M, Hanspers SK, Barker CS, Korn AP, McCune JM. Gene expression profiles during human CD4+ T cell differentiation. Int Immunol 2004; 16:1109-24.
40. Olaussen RW, Farstad IN, Brandtzaeg P, Rugtveit J. Age-related changes in CCR9+ circulating lymphocytes: are CCR9+ naive T cells recent thymic emigrants? Scand J Immunol 2001; 54:435-9.
41. Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001; 98:2736-44.
42. Thornton CA, Upham JW, Wikstrom ME, Holt BJ, White GP, Sharp MJ, Sly PD, Holt PG. Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens. J Immunol 2004; 173:3084-92.
43. Takahata Y, Nomura A, Takada H et al. CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp Hematol 2004; 32:622-9.
44. Godfrey WR, Spoden DJ, Ge YG et al. Cord blood CD4+CD25+ derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 2004; 105:750-8.
45. Levings M, Sangregorio KR, Galbiati F, Squadrone S, de Waal MR, Roncarolo MG. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001; 166:5530-9.
46. Ota MO, Vekemans J, Schlegel-Haueter SE et al. Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. Vaccine 2004; 22:511-9.
47. Vekemans J, Ota MO, Wang EC et al. T cell responses to vaccines in infants: defective IFNgamma production after oral polio vaccination. Clin Exp Immunol 2002; 127:495-8.
48. Hussey GD, Watkins ML, Goddard EA, Gottschalk S, Hughes EJ, Iloni K, Kibel MA, Ress SR. Neonatal mycobacterial specific cytotoxic T-lymphocyte and cytokine profiles in response to distinct BCG vaccination strategies. Immunology 2002; 105:314-24.
49. Marchant A, Goetghebuer T, Ota MO et al. Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination. J Immunol 1999; 163:2249-55.
50. Vekemans JA, Amedei MO, Ota MM, D'Elios T, Goetghebuer J, Ismaili MJ, Newport G, Del Prete M, Goldman KP. McAdam, and A. Marchant. Neonatal bacillus Calmette-Guerin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur J Immunol 2001; 31:1531-5.
51. Black GF, Weir RE, Floyd S et al. BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies. Lancet 2002; 20:1393-401.
52. Mascart FV, Verscheure A, Malfroot M et al. Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. J Immunol 2003; 170:1504-9.
53. Gans H, Yasukawa L, Rinki M, et al. Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months. J Infect Dis 2001; 184:817-26.
54. Henderson RA, Watkins SC, Flynn JL. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J Immunol 1997; 159:635-43.
55. Inaba K, Inaba M, Naito M, Steinman RM. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 1993; 178:479-88.
56. Tonon SS, Goriely E, Aksoy O et al. Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. Eur J Immunol 2002; 32:3118-25.
57. Ausiello CM, Fedele G, Urbani F, Lande R, Di Carlo B, Cassone A. Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses. J Infect Dis 2002; 186:351-60.
58. Ota MO, Vekemans J, Schlegel-Haueter SE et al. Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination. J Immunol 2002; 168:919-25.
59. Aaby P, Shaheen SO, Heyes CB, Goudiaby A, Hall AJ, Shiell AW, Jensen H, Marchant A. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy 2000; 30:644-50.
60. Annus T, Montgomery SM, Riikjarv MA, Bjorksten B. Atopic disorders among Estonian schoolchildren in relation to tuberculin reactivity and the age at BCG vaccination. Allergy 2004; 59:1068-73.
61. Bager P, Rostgaard K, Nielsen NM, Melbye M, Westergaard T. Age at bacille Calmette-Guerin vaccination and risk of allergy and asthma. Clin Exp Allergy 2003; 33:1512-7.
62. da Cunha SS, Cruz AA, Dourado I, Barreto ML, Ferreira LD, Rodrigues LC. Lower prevalence of reported asthma in adolescents with symptoms of rhinitis that received neonatal BCG. Allergy 2004; 59:857-62.
63. Townley RG, Barlan IB, Patino C et al. The effect of BCG vaccine at birth on the development of atopy or allergic disease in young children. Ann Allergy Asthma Immunol 2004; 92:350-5.
64. von Hertzen LC, Haahtela T. Immunization and atopy: possible implications of ethnicity. J Allergy Clin Immunol 2004; 113:401-6.
65. Kristensen I, Aaby P, Jensen H. Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa. Br Med J 2000; 321:1435-8.
66. Stensballe LG, Nante E, Jensen IP, Kofoed PE, Poulsen A, Jensen H, Newport M, Marchant A, Aaby P. Acute lower respiratory tract infections and respiratory syncytial virus in children in Guinea-Bissau: a beneficial effect of BCG vaccination for girls. Vaccine 2005; 23:1251-7.
67. Aaby P, Jensen H. Routine vaccination and child survival in Guinea-Bissau. Author's reply to commentary. Br Med J 2001; 322:360.
68. Shann F. Non-specific effects of vaccines in developing countries. We need evidence about the effect of vaccines on mortality from all causes. Br Med J 2000; 321:1423-4.
69. Fine P. Commentary: an unexpected finding that needs confirmation or rejection. Br Med J 2000; 321:1439.
70. Gibson L, Piccinini G, Lilleri D, Revello MG, Wang Z, Markel S, Diamond DJ, Luzuriaga K. Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol 2004; 172:2256-64.
71. Marchant AV, Appay SM, Van Der N et al. Mature CD8(+) T lymphocyte response to viral infection during fetal life. J Clin Invest 2003; 111:1747-55.
72. Appay VPR, Dunbar M, Callan P et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8:379-85.
73. Tomiyama H, Takata H, Matsuda T, Takiguchi M. Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function. Eur J Immunol 2004; 34:999-1010.
74. Wills MR, Okecha G, Weekes MP, Gandhi MK, Sissons PJ, Carmichael AJ. Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response. J Immunol 2002; 168:5455-64.
75. Chen SF, Tu WW, Sharp MA et al. Antiviral CD8 T cells in the control of primary human cytomegalovirus infection in early childhood. J Infect Dis 2004; 189:1619-27.
76. Chakraborty R, Gillespie GM, Reinis M et al. HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate. AIDS 2002; 16:2085-7.
77. Sandberg JK, Fast NM, Jordan KA et al. HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartment. J Immunol 2003; 170:4403-10.
78. Buseyne F, Burgard M, Teglas JP, Bui E, Rouzioux C, Mayaux MJ, Blanche S, Riviere Y. Early HIV-specific cytotoxic T lymphocytes and disease, progression in children born to HIV-infected mothers. AIDS Res Hum Retroviruses 1998; 14:1435-44.
79. Pikora CA, Sullivan JL, Panicali D, Luzuriaga K. Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J Exp Med 1997; 185:1153-61.
80. Luzuriaga K, Holmes D, Hereema A, Wong J, Panicali DL, Sullivan JL. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J Immunol 1995; 154:433-43.
81. Wasik TJ, Jagodzinski PP, Hyjek EM, Wustner J, Trinchieri G, Lischner HW, Kozbor D. Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. J Immunol 1997; 158:6029-36.
82. Scott ZA, Chadwick EG, Gibson LL et al. Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants. J Immunol 2001; 167:7134-40.
83. Appay VDF, Nixon SM, Donahoe GM et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 2000; 192:63-75.
84. Champagne PGS, Ogg AS, King C et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001; 410:106-11.
85. Papagno L, Spina CA, Marchant A et al. Immune Activation and CD8(+) T-Cell Differentiation towards Senescence in HIV-1 Infection. Plos Biol 2004; 2:E20.
86. Goulder PJ, Brander C, Tang Y et al. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature 2001; 412:334-8.
87. MacDonald KS, Embree J, Njenga S et al. Mother-child class IHLA concordance increases perinatal human immunodeficiency virus type 1 transmission. J Infect Dis 1998; 177:551-6.
88. Hermann E, Truyens C, Alonso-Vega C et al. Human fetuses are able to mount an adultlike CD8 T-cell response. Blood 2002; 100:2153-8.
89. Isaacs D, Bangham CR, McMichael AJ. Cell-mediated cytotoxic response to respiratory syncytial virus in infants with bronchiolitis. Lancet 1987; 2:769-71.
90. Mbawuike IN, Wells J, Byrd R, Cron SG, Glezen WP, Piedra PA. HLA-restricted CD8+ cytotoxic T lymphocyte, interferon-gamma, and interleukin-4 responses to respiratory syncytial virus infection in infants and children. J Infect Dis 2001; 183:687-96.
91. Jaye A, Magnusen AF, Sadiq AD, Corrah T, Whittle HC. Ex vivo analysis of cytotoxic T lymphocytes to measles antigens during infection and after vaccination in Gambian children. J Clin Invest 1998; 102:1969-77.
92. Gamadia LE, Remmerswaal EB, Weel JF, Bemelman F, van Lier RA, Ten Berge IJ. Primary immune responses to human CMV. a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood 2003; 101:2686-92.
93. Weekes MP, Wills MR, Sissons JG, Carmichael AJ. Long-term stable expanded human CD4+ T cell clones specific for human cytomegalovirus are distributed in both CD45RAhigh and CD45ROhigh populations. J Immunol 2004; 173:5843-51.
94. van Leeuwen EM, Remmerswaal EB, Vossen MT, Rowshani AT, Wertheim-van Dillen PM, van Lier RA, Ten Berge IJ. Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol 2004; 173:1834-41.
95. Bitmansour AD, Douek DC, Maino VC, Picker LJ. Direct ex vivo analysis of human CD4(+) memory T cell activation requirements at the single clonotype level. J Immunol 2002; 169:1207-18.
96. Kern F, Bunde T, Faulhaber N et al. Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis 2002; 185:1709-16.
97. Tu W, Chen S, Sharp M, Dekker C et al. Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children. J Immunol 2004; 172:3260-7.
98. Pass RF, Stagno S, Britt WJ, Alford CA. Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirus. J Infect Dis 1983; 148:953-61.
99. Jonjic S, Mutter W, Weiland F, Reddehase MJ, Koszinowski UH. Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. J Exp Med 1989; 169:1199-212.
100. Feeney ME, Draenert R, Roosevelt KA et al. Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection. J Immunol 2003; 171:6968-75.
101. Scott ZA, Beaumier CM, Sharkey M, Stevenson M, Luzuriaga K. HIV-1 replication increases HIV-specific CD4+ T cell frequencies but limits proliferative capacity in chronically infected children. J Immunol 2003; 170:5786-92.
102. Burchett SK, Corey L, Mohan KM, Westall J, Ashley R, Wilson CB. Diminished interferon-gamma and lymphocyte proliferation in neonatal and postpartum primary herpes simplex virus infection. J Infect Dis 1992; 165:813-8.
103. Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, Kazura JW, King CL. Helminth- and Bacillus Calmette-Guerin-induced immunity in children sensitized in utero to filariasis and schistosomiasis. J Immunol 1999; 162:6843-8.
104. Malhotra I, Ouma J, Wamachi A et al. In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults. J Clin Invest 1997; 99:1759-66.
105. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5:987-95.
106. Goriely SB, Vincart P, Stordeur J, Vekemans F, Willems M. Goldman, and D. De Wit. Deficient IL-12 (p35) gene expression by dendritic cells derived from neonatal monocytes. J Immunol 2001; 166:2141-6.
107. Goriely S, Demonte D, Nizet S, De Wit D, Willems F, Goldman M, Van Lint C. Human IL-12 (p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical Spl-binding sites. Blood 2003; 101:4894-902.
108. Goriely S, Van Lint C, Dadkhah R, Libin M, De Wit D, Demonte D, Willems F, Goldman M. a defect in nucleosome remodeling prevents IL-12 (p35) gene transcription in neonatal dendritic cells. J Exp Med 2004; 199:1011-6.
109. Langrish CL, Buddle JC, Thrasher AJ, Goldblatt D. Neonatal dendritic cells are intrinsically biased against Th-1 immune responses. Clin Exp Immunol 2002; 128:118-23.
110. Upham JW, Lee PT, Holt BJ, Heaton T, Prescott SL, Sharp MJ, Sly PD, Holt PG. Development of interleukin-12-producing capacity throughout childhood. Infect Immun 2002; 70:6583-8.
111. De Wit D, Olislagers V, Goriely S, Vermeulen F, Wagner H, Goldman M, Willems F. Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns. Blood 2004; 103:1030-2.
112. Salio M, Dulphy N, Renneson J, Herbert M, McMichael A, Marchant A, Cerundolo V. Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells. Int Immunol 2003; 15:1265-73.