Serum levels of cathepsin K decrease with age in both women and men

Experimental Gerontology

Volumn 40, Issue 6, 2005, Pages 532-535

  Kerschan Schindl, K ^a   Hawa, G ^b   Kudlacek, S ^c,d   Woloszczuk, W ^d   Pietschmann, P ^a,d  

^a UNIVERSITY OF VIENNA   (Austria)

^b Biomedica Group   (Austria)

^c KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Austria)

^d LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Age; Bone metabolism; Cathepsin K; Gender

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; CATHEPSIN K; CYSTEINE PROTEINASE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

ADULT; AGED; ARTICLE; BONE MATRIX; CELL ACTIVATION; CELL DIFFERENTIATION; CORRELATION ANALYSIS; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; EVALUATION; FEMALE; GENDER; HUMAN; INHIBITION KINETICS; MALE; NORMAL HUMAN; OSTEOCLAST; OSTEOLYSIS; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADULT; AGED, 80 AND OVER; AGING; ALKALINE PHOSPHATASE; BONE AND BONES; BONE RESORPTION; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; FEMALE; GLYCOPROTEINS; HUMANS; MALE; OSTEOCALCIN; OSTEOPROTEGERIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; SEX FACTORS; VITAMIN D;

EID: 21244471809     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.04.001     Document Type: Article

References (31)

1. Anonymous Osteoporosis prevention, diagnosis and therapy J. Am. Med. Assoc. 285 2001 785 795
2. M. Bossard, T. Tomaszek, M. Levy, C. Ijames, M. Huddleston, J. Briand, S. Thompson, S. Halpert, D. Veber, S. Carr, T. Meek, and D. Tew Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases Biochemistry 38 1999 15893 15902
3. D. Bromme, and K. Okamoto Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution Biol. Chem. Hoppe Seyler. 376 1995 379 384
4. F. Buhling, A. Gerber, C. Hackel, S. Kruger, T. Kohnlein, D. Bromme, D. Reinhold, S. Ansorge, and T. Welte Expression of cathepsin K in lung epithelial cells Am. J. Respir. Cell Mol. Biol. 20 1999 612 619
5. S. Corsideo, M. Gyda, M. Zaidi, B.S. Moonga, and B.R. Troen New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand Biochem. Biophys. Res. Commun. 285 2001 335 339
6. V. Everts, J.M. Delaisse, W. Korper, and W. Beertsen Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone J. Bone Miner. Res. 13 1998 1420 1430
7. P. Garnero, E. Sornay-Rendu, M.C. Chapuy, and P.D. Delmas Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis J. Bone Miner. Res. 11 1996 337 349
8. P. Garnero, O. Borel, I. Byrjalsen, M. Ferreras, F.H. Drake, M.S. McQueney, N.T. Foged, P.D. Delmas, and J.M. Delaisse The collagenolytic activity of cathepsin K is unique among mammalian proteinases J. Biol. Chem. 273 1998 32347 32352
9. B.D. Gelb, G.-P. Shi, H.A. Chapman, and R.J. Desnick Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency Science 273 1996 1236 1239
10. M. Gowen, F. Lazner, R. Dodds, R. Kapadis, J. Feild, M. Tavaris, I. Bertoncello, F. Drake, S. Zavarselk, I. Tellis, P. Hertzog, C. Debouck, and I. Kola Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not mineralization J. Bone Miner. Res. 14 1999 1654 1663
11. E. Greenfield, Y. Bi, and A. Miyauchi Minireview - regulation of osteoclast activity Life Sci. 65 1999 1087 1102
12. D.E. Hughes, A. Dai, J.C. Tiffee, H.H. Li, G.R. Mundy, and B.F. Boyce Estrogen promotes apoptosis of murine osteoclasts mediated TGF-beta Nat. Med. 2 1996 1132 1136
13. T. Inui, O. Ishibashi, T. Inaoka, Y. Origane, M. Kumegawa, T. Kokubo, and T. Yamamura Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption J. Biol. Chem. 272 1997 8109 8112
14. S. Khosla, H.M. Arrighi, L.J. Melton 3rd, E.J. Atkinson, W.M. O'Fallon, C. Dunstan, and B.L. Riggs Correlates of osteoprotegerin levels in women and men Osteoporos. Int. 13 2002 394 399
15. R. Kiviranta, J. Morko, S.L. Alatalo, R. NicAmhlaoibh, J. Risteli, T. Laitala-Leinonen, and E. Vuorio Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio Bone 36 2005 159 172
16. S. Kudlacek, B. Schneider, W. Woloszczuk, P. Pietschmann, and R. Willvonseder Serum levels of osteoprotegerin increase with age in a healthy adult population Bone 32 2003 681 686
17. G.J. Ligthart, J.X. Corberand, C. Fournier, P. Galanaud, W. Hijmans, B. Kennes, H.K. Müller-Hermelink, and G.G. Steinmann Admission criteria for immunogerontological studies in man: the SENIEUR protocol Mech. Ageing Dev. 28 1984 47 55
18. R.W. Marquis, Y. Ru, D.S. Yamashita, H.J. Oh, J. Yen, S.K. Tompson, T.J. Carr, M.A. Levy, T.A. Tomaszek, C.F. Ijames, W.W. Smith, B. Zhao, C.A. Janson, S.S. Abdel-Meguid, K.J. D'Alessio, M.S. McQueney, and D.F. Veber Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K Bioorg. Med. Chem. 7 1999 581 588
19. R.W. Marquis, Y. Ru, J. Zeng, R.E. Trout, S.M. LoCastro, A.D. Gribble, J. Witherington, A.E. Fenwick, B. Garnier, T. Tomaszek, D. Tew, M.E. Hemling, C.J. Quinn, W.W. Smith, B. Zhao, M.S. McQueney, C.A. Janson, K. D'Alessio, and D.F. Veber Cyclic ketone inhibitors of the cysteine protease cathepsin K J. Med. Chem. 44 2001 725 736
20. P. Pietschmann, E. Gollob, S. Brosch, P. Hahn, S. Kudlacek, M. Willheim, W. Woloszczuk, M. Peterlik, and K.H. Tragl The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism Exp. Gerontol. 38 2003 1119 1127
21. P. Saftig, E. Hunziker, O. Wehmexer, S. Jones, A. Boyde, W. Rommerskirch, J.D. Moritz, P. Schu, and K. Von Figura Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice Proc. Natl Acad. Sci. USA 95 1998 13453 13458
22. W.S. Simonet, D.L. Lacey, C.R. Dunstan, M. Kelley, M.S. Chang, R. Luthy, H.Q. Nguyen, S. Wooden, L. Bennett, T. Boone, G. Shimamoto, M. DeRose, R. Elliott, A. Colombero, H.L. Tan, G. Trail, J. Sullivan, E. Davy, N. Bucay, L. Renshaw-Gegg, T.M. Hughes, D. Hill, W. Pattison, P. Campbell, and W.J. Boyle Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 1997 309 319
23. M. Takahashi, M. Oikawa, and A. Nagano Effect of age and menopause on serum concentrations of pentosidine, an advanced glycation end product J. Gerontol. A. Biol. Sci. Med. Sci. 55 2000 M137 M140
24. Tepel, C., Bromme, D., Herzog, V., Brix, K., 2000. Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J. Cell. Sci. 113 Pt 24, 4487-4498.
25. B.R. Troen Molecular mechanisms underlying osteoclast formation and activation Exp. Gerontol. 38 2003 606 614
26. E. Tsuda, M. Goto, S. Mochizuki, K. Yano, F. Kobayashi, T. Morinaga, and K. Higashio Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis Biochem. Biophys. Res. Commun. 234 1997 137 142
27. B. Votta, M. Levey, A. Badger, J. Bradbeer, R. Dodds, I. James, S. Thompson, M. Bossard, T. Carr, J. Connor, T. Tomaszek, L. Szewczuk, F. Drake, D. Veber, and M. Gowen Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo J. Bone Miner. Res. 12 1997 1396 1406
28. Y. Wittrant, S. Couillaud, S. Theoleyre, C. Dunstan, D. Heymann, and R. Redini Osteoprotegerin differentially regulates protease expression in osteoclast cultures Biochem. Biophys. Res. Commun. 293 2002 38 44
29. L. Xia, J. Kilb, H. Wex, Z. Li, A. Lipyansky, V. Breuil, L. Stein, J.T. Palmer, D.W. Dempster, and D. Bromme Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones J. Biol. Chem. 380 1999 679 687
30. M. Zaidi, B. Troen, B. Moonga, and E. Abe Cathepsin K, osteoclastic resorption, and osteoporosis therapy J. Bone Miner. Res. 16 2001 1739 1746
31. M. Zaidi, H. Blair, B. Moonga, E. Abe, and C. Huang Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics J. Bone Miner. Res. 18 2003 599 609