Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation

Journal of Medicinal Chemistry

Volumn 48, Issue 13, 2005, Pages 4378-4388

  De Martino, Gabriella ^a   Regina, Giuseppe La ^a   Pasquali, Alessandra Di ^a   Ragno, Rino ^a   Bergamini, Alberto ^b   Ciaprini, Chiara ^b   Sinistro, Anna ^b   Maga, Giovanni ^c   Crespan, Emmanuele ^c   Artico, Marino ^a   Silvestri, Romano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (DIPHENYLMETHOXY)ETHYL] 2 METHYL 5 NITROIMIDAZOLE; 1 [2 [ALPHA (THIOPHEN 2 YL)PHENYLMETHOXY]ETHYL] 2 METHYL 5 NITROIMIDAZOLE; EFAVIRENZ; NITROIMIDAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; RS 1478; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CHIRALITY; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; ENANTIOMER; MUTATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CELL LINE; CELL SURVIVAL; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEVIRAPINE; NITROIMIDAZOLES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 21244459659     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050273a     Document Type: Article

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