Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1123-1132

  Stephens, Chad E ^a   Felder, Takita M ^a   Sowell Sr , J Walter ^a   Andrei, Graciela ^b   Balzarini, Jan ^b   Snoeck, Robert ^b   De Clercq, Erik ^b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETAMIDO 3 (4 CHLOROPHENYLSULFONYL) 5 NITROTHIOPHENE; 2 ACETAMIDO 3 (4 FLUOROPHENYLSULFONYL) 5 NITROTHIOPHENE; 2 AMINO 1 [2 (4 CHLOROPHENYL)ETHYL] 3 (4 CHLOROPHENYLSULFONYL) 4,5 DIMETHYLPYRROLE; 2 AMINO 3 (2 NITROPHENYLSULFONYL)THIOPHENE; 2 AMINO 3 (4 CHLOROPHENYLSULFONYL) 1 (4 METHOXYBENZYL) 4,5 DIMETHYLPYRROLE; 2 AMINO 3 (4 CHLOROPHENYLSULFONYL) 4,5 DIMETHYL 1 (1 NAPHTHYLMETHYL)PYRROLE; 2 AMINOSULFONYLTHIOPHENE DERIVATIVE; 2 BENZAMIDO 3 (4 METHYLPHENYLSULFONYL)THIOPHENE; 2 CARBOXAMIDOSULFONYLTHIOPHENE DERIVATIVE; 3 (4 CHLOROPHENYLSULFONYL) 2 (TRIFLUOROACETAMIDO)THIOPHENE; 3 (4 FLUOROPHENYLSULFONYL) 2 (TRIFLUOROACETAMIDO)THIOPHENE; 3 (4 METHYLPHENYLSULFONYL) 2 (TRIFLUOROACETAMIDO)THIOPHENE; 3 [(2 METHOXYCARBONYL)PHENYLSULFONYL] 2 (TRIFLUOROACETAMIDO)THIOPHENE; 3 PHENYLSULFONYL 2 (3 PYRIDYLCARBOXAMIDO)THIOPHENE; 3 PHENYLSULFONYL 2 (TRIFLUOROACETAMIDO)THIOPHENE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; SULFONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA; NONHUMAN; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ARYLSULFONIC ACIDS; BREAST NEOPLASMS; CELLS, CULTURED; COLONIC NEOPLASMS; CYTOMEGALOVIRUS; HIV-1; HIV-2; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; SIMPLEXVIRUS; THIOPHENES;

EID: 0035018516     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00333-3     Document Type: Article

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