Ebselen-binding equilibria between plasma and target proteins

Biochemical Pharmacology

Volumn 52, Issue 1, 1996, Pages 15-19

  Ullrich, Volker ^a   Weber, Peter ^a   Meisch, Frank ^a   Von Appen, Frank ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

albumin; covalent binding; difference spectroscopy; ebselen; platelets; polymorphonuclear leukocytes; thiol group

Indexed keywords

ALBUMIN; ANTIINFLAMMATORY AGENT; CELL PROTEIN; EBSELEN; GLUTATHIONE; N ETHYLMALEIMIDE; RADIOISOTOPE; THIOL;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG TARGETING; EQUILIBRIUM CONSTANT; EQUILIBRIUM DIALYSIS; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN BINDING; STOICHIOMETRY; THROMBOCYTE;

EID: 0029997840     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00109-8     Document Type: Article

References (15)

1. Sies H, Ebselen, A selenoorganic compound as glutathione peroxidase mimic. Free Radical Biol Med 14: 313-323, 1993.
2. Schewe T, Molecular actions of ebselen - an antiinflammatory antioxidant. Gen Pharmac 26(6): 1153-1169, 1995.
3. Parnham MJ, Leyck S, Graf E, Dowling EJ and Blake DR, The pharmacology of ebselen. Agents Actions 32: 4-9, 1991.
4. Dimmeler S, Brüne B and Ullrich V, Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor. Biochem Pharmacol 42: 1151-1153, 1991.
5. Hattori R, Inoue R, Sase K, Eizawa H, Kosuga K, Aoyama T, Masayasu H, Kawai C, Sasayama S and Yui Y, Preferential inhibition of inducible nitric oxide synthase by ebselen. Eur J Pharmacol 267: R1-R2, 1994.
6. 4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-transisomer. Prostaglandins 31: 1029-1048, 1986.
7. Oshita M, Takei Y, Kawano S, Fusamoto H and Kamada T, Protective effect of ebselen on constrictive hepatic vasculature: Prevention of alcohol-induced effects on portal pressure in perfused livers. J Pharmacol Exp Ther 271: 20-24, 1994.
8. Kamigata N, Takata M, Matsuyama H and Kobayashi M, Novel ring opening reaction of 2-aryl-1,2-benzisoselenazo3(2H)-one with thiols. Heterocycles 24: 3027-3030, 1986b.
9. Nomura H, Hakusui H and Takegoshi T, Binding of ebselen to plasma protein. In: Wendel, A (ed.): Selenium in Biology and Medicine, Springer Verlag Heidelberg, 189-193, 1989.
10. Wagner G, Schuch G, Akerboom TPM and Sies H, Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. Biochem Pharmacol 48: 1137-1144, 1994.
11. Renson M and Piette J-L, Etude des propriétés du chlorure d'o-chloroséléobenzoyle application à la synthèse d'o-alcoylsélénoacylophénones. Bull Soc Chim Belg 13: 507-517, 1964.
12. 2 formation. J Biol Chem 266(29): 19232-19237, 1991.
13. Brüne B and Ullrich V, Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol 32: 497-504, 1987.
14. Hatzelmann A and Ullrich V, Regulation of 5-lipoxygenase activity by the glutathione status in human polymorphonuclear leukocytes. Eur J Biochem 169: 175-184, 1987.
15. Haenen GRMM, De Rooij BM, Veremeulen NPE and Bast A, Mechanism of the reaction of ebselen with endogenous thiols. Mol Pharmacol 37: 412-422, 1989.