Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications

Vascular Pharmacology

Volumn 42, Issue 5-6, 2005, Pages 219-232

  Kukreja, Rakesh C ^a   Salloum, Fadi ^a   Das, Anindita ^a   Ockaili, Ramzi ^a   Yin, Chang ^a   Bremer, Yvonne A ^a   Fisher, Patrick W ^a   Wittkamp, Michael ^a   Hawkins, John ^a   Chou, Eric ^a   Kukreja, Amit K ^a   Wang, Xiaoyin ^a   Marwaha, Vijay R ^a   Xi, Lei ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cGMP; Endothelial dysfunction; Ischemia reperfusion injury; Myocardial preconditioning; Nitric oxide; Phosphodiesterase inhibitors; Potassium channel; Protein kinase; Pulmonary hypertension; Vasodilatation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 HYDROXYDECANOIC ACID; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; POTASSIUM CHANNEL; PROTEIN KINASE C; SILDENAFIL; TADALAFIL; VARDENAFIL; ZAPRINAST;

APOPTOSIS; ARTERIAL PRESSURE; CELL DEATH; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ANALYSIS; ERECTILE DYSFUNCTION; HEART ARRHYTHMIA; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART OUTPUT; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEMODYNAMICS; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MYOCARDIAL REPERFUSION INJURY; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES;

EID: 21144435779     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2005.02.010     Document Type: Review

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