Discovery of a novel and potent human and rat β3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl] -1H-indol-7-yloxy]acetic acid

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 2, 2005, Pages 184-198

  Harada, Hiroshi ^a   Hirokawa, Yoshimi ^a   Suzuki, Kenji ^a   Hiyama, Yoichi ^a   Oue, Mayumi ^a   Kawashima, Hitoshi ^a   Kato, Hiroshi ^a   Yoshida, Naoyuki ^a   Furutani, Yasuji ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

3 adrenergic receptor agonist; AJ 9677; Indole; Obesity; Type II diabetes

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID METHYL ESTER; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; [3 [[[(3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1H INDOL 7 YLOXY]ACETIC ACID; [[7 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO] 5,6,7,8 TETRAHYDRO 2 NAPHTHYL]OXY]ACETIC ACID ETHYL ESTER; AJ 9677; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARBOXYLIC ACID; CYCLOHEXYL[4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENOXYMETHYL]PHOSPHINIC ACID; INDOLE DERIVATIVE; L 755507; L 770644; LY 377604; UNCLASSIFIED DRUG; ((3 ((2R) (((2R) 3 CHLOROPHENYL) 2 HYDROXYETHYL)AMINO)PROPYL) 1H INDOL 7 YLOXY)ACETIC ACID; ((3-((2R)-(((2R)-3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO)PROPYL)-1H-INDOL-7-YLOXY)ACETIC ACID; ACETIC ACID DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; CYCLIC AMP; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FATTY ACID; INSULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CHO CELL; DRUG STRUCTURE; DRUG SYNTHESIS; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BLOOD; BODY WEIGHT; CHEMICAL STRUCTURE; COLON; CONFORMATION; DRUG EFFECT; DRUG POTENTIATION; HUMAN; MALE; METABOLISM; MUSCLE CONTRACTION; RAT; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ACETIC ACIDS; ADRENERGIC BETA-AGONISTS; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; COLON; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; FATTY ACIDS, NONESTERIFIED; HUMANS; INDICATORS AND REAGENTS; INDOLES; INSULIN; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OBESITY; RATS; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 21044449411     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.53.184     Document Type: Article

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