Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Selectivity is enhanced at the level of receptor binding

Medicinal Chemistry Research

Volumn 7, Issue 2, 1997, Pages 109-115

  Sher, Philip M ^a   Fisher, Liesl G ^a,b   Skwish, Stephen ^a   Michel, Inge M ^a   Seiler, Steven M ^a   Washburn, William N ^a   Dickinson, Kenneth E J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

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EID: 0001423561     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

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7. 3 over β2, than BRL 35135. See also reference 11.
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14. 2 activity.
15. 2.
16. 3 AR binding experiments comparing acids with esters were reported.10b
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30. th American Chemical Society National Meeting, San Diego, CA, MEDI 230, March 13-17, 1994.
31. A carboxylic acid is smaller than an ester or amide and more polar since it is ionized, and unlike an ester it can function as a H-bond donor.