Quantification of gluconeogenesis in cirrhosis: Response to glucagon

Gastroenterology

Volumn 115, Issue 6, 1998, Pages 1530-1540

  Bugianesi, E ^a   Kalhan, S ^a   Burkett, E ^a   Marchesini, G ^a   McCullough, A ^a  

^a Center for Metabolism and Nutrition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BILIRUBIN; COLESTYRAMINE; DIURETIC AGENT; GLUCOSE; GLYCOGEN; LACTULOSE; OMEPRAZOLE; PROTHROMBIN; UREA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLYCOGEN LIVER LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; LIVER CIRRHOSIS; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; UREA CYCLE;

EID: 0031787872     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70033-2     Document Type: Article

References (37)

1. AJ McCullough AS Tavill Disordered energy and protein metabolism in liver disease Semin Liv Dis 11 1991 265 277
2. MJ Muller HU Lautz B Plogmann M Burger J Korber FW Schmidt Energy expenditure and substrate oxidation in patients with cirrhosis: the impact of cause, clinical staging and nutritional state Hepatology 15 1992 782 794
3. JA Romjin E Endret HP Sauerwein Glucose and fat metabolism during short-term starvation in cirrhosis Gastroenterology 100 1991 731 737
4. M Merli O Riggio A Romiti F Ariosto L Mango G Pinto M Savioli L Capocaccia Basal energy production rate and substrate use in stable cirrhotic patients Hepatology 12 1990 106 112
5. B Schneeweiss W Graninger P Ferenci S Eichinger G Grimm B Schneider AN Laggner K Lenz G Kleinberger Energy metabolism in patients with acute and chronic liver disease Hepatology 11 1990 387 393
6. P Cavallo-Perin M Cassader C Bozzo A Bruno P Nuccio AM Dall'Omo M Marucci Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect J Clin Invest 75 1985 1659 1665
7. OE Owen FA Reichle MA Mozzoli T Kreulen MS Patel IB Elfenbein M Golsorkhi Hepatic, gut and renal substrate flux rates in patients with hepatic cirrhosis J Clin Invest 68 1981 240 252
8. E Shmueli M Walker G Alberti CO Record Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis Hepatology 18 1981 86 95
9. R Nosadini A Avogaro F Mollo C Marescotti A Tiengo E Duner C Merkel Carbohydrate and lipid metabolism in cirrhosis: evidence that hepatic uptake of gluconeogenic precursors and of free fatty acids depends on effective hepatic flow J Clin Endocrinol Metab 58 1984 1125 1132
10. R Sherwin P Joshi R Hendler P Felig HO Conn Hyperglucagonemia in Laennec's cirrhosis N Engl J Med 290 1984 239 242
11. AS Petrides RA DeFronzo Failure of glucagon to stimulate hepatic glycogenolysis in well nourished patients with mild cirrhosis Metabolism 43 1984 85 89
12. U Keller GE Sonnenberg E Burckhardt A Perruchoud Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver J Clin Endocrinol Metab 54 1984 961 968
13. G Marchesini G Bianchi M Zoli C Dondi G Forlani A Melli V Bua Plasma amino acid response to protein ingestion in patients with liver cirrhosis Gastroenterology 85 1983 283 290
14. RC Strange OD Mjos T Hender P Jynge The effect of glucagon on plasma cyclic AMP and glucose concentrations in patients with alcoholic cirrhosis Acta Med Scand 202 1977 87 88
15. A Francavilla A Jones TE Starzl Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced cirrhosis Gastroenterology 75 1978 1026 1032
16. SB Heymsfield S Lichtman RN Baumgartner J Wang Y Kamen A Aliprantis RN Pierson Body composition of humans: comparison of two improved four-compartment models that differ in expense, technical complexity and radiation exposure Am J Clin Nutr 52 1990 52 58
17. AJ McCulough KD Mullen SC Kalhan Measurement of total body and extracellular water in cirrhotic patients with and without ascites Hepatology 14 1991 1102 1111
18. B Assel K Rossi SC Kalhan Glucose metabolism during fasting through human pregnancy: comparison of tracer method with respiratory calorimetry Am J Physiol 265 1978 E351 E356
19. KN Frayn Calculation of substrate oxidation rates in vivo from gaseous exchange J Appl Physiol 55 1983 628 634
20. BR Landau J Wahren V Chandramouli WC Schumann K Ekberg SC Kalhan Contributions of gluconeogenesis to glucose production in the fasted state J Clin Invest 98 1996 378 385
21. SC Kalhan R Trivedi S Singh V Chandramouli WC Schumann BR Landau A micromethod for the measurement of deuterium bound to carbon 6 of glucose to quantify gluconeogenesis in vivo J Mass Spectrom 30 1995 1588 1592
22. SC Kalhan K Rossi L Gruca E Burkett A O'Brien Glucose turnover and gluconeogenesis in human pregnancy J Clin Invest 100 1997 1775 1781
23. 15N]urea in plasma and application to urea metabolism study Anal Chem 54 1982 489 491
24. KY Tserng SC Kalhan Calculation of substrate turnover rate in stable isotope tracer studies Am J Physiol 245 1983 E308 E311
25. JS Cowan C Hetenyi Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method Metabolism 20 1971 360 372
26. JL Chiasson L Lijenquist WW Lacy A Jennings AD Cherrington Gluconeogenesis. Methodologic approaches in vivo Fed Proc 36 1997 229 235
27. I Magnusson DL Rothman LD Katz RG Shulman FI Shulmann Increased rate of gluconeogenesis in type II diabetes mellitus J Clin Invest 90 1992 1323 1327
28. O Bjorkman LS Eriksson B Nyberg J Wahren Gut exchange of glucose and lactate in basal state and after oral glucose ingestion in postoperative patients Diabetes 39 1990 747 751
29. B Campillo P Bories M Devanlay F Sommer E Wirquin P Fouet The thermogenic and metabolic effects of food in liver cirrhosis: consequences on the storage of nutrients and the hormonal counterregulatory response Metabolism 41 1992 476 482
30. YT Kruszynska A Meyer-Alber F Darakhshan PD Home N McIntyre Metabolic handling of orally administered glucose in cirrhosis J Clin Invest 91 1993 1057 1066
31. AS Petrides L Groop CA Rieley RA DeFronzo Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis J Clin Invest 88 1991 561 570
32. AS Petrides RA De Fronzo Glucose metabolism in cirrhosis: a review with some perspectives for the future Diab Metab Rev 5 1989 691 709
33. L Lecavalier G Bolli J Gerich Glucagon-cortisol interactions on glucose turnover and lactate gluconeogenesis in normal humans Am J Physiol 258 1990 E569 E575
34. G Marchesini G Pacini G Bianchi D Patrono C Cobelli Glucose disposal, b-cell secretion, and hepatic insulin extraction in cirrhosis: a minimal model assessment Gastroenterology 99 1990 1715 1722
35. KD Mullen SC Denne AJ McCullough SM Savin D Bruno AS Tavill SC Kalhan Leucine metabolism in stable cirrhosis Hepatology 6 1986 622 630
36. A Fabbri G Marchesini G Bianchi E Bugianesi L Bortoluzzi M Zoli E Pisi Unresponsiveness of hepatic nitrogen metabolism to glucagon infusion in patients with cirrhosis: dependence on liver cell failure Hepatology 18 1993 28 35
37. A Martin-Requero G Cipres A Rodriguez MS Ayuso R Parilla On the mechanism of stimulation of ureagenesis by gluconeogenic substrates: role of pyruvate carboxylase Am J Physiol 263 1992 E493 E499