Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

Journal of Neurochemistry

Volumn 77, Issue 6, 2001, Pages 1611-1625

  Neystat, Michael ^a   Rzhetskaya, Margarita ^a   Oo, Tinmarla F ^a   Kholodilov, Nikolai ^a   Yarygina, Olga ^a   Wilson, Alexandria ^a   El Khodor, Bassem F ^a   Burke, Robert E ^a,b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

cdk5; Neurofilament; Parkinson's disease; Programmed cell death; Substantia nigra; Tau

Indexed keywords

CYCLIN DEPENDENT KINASE 5; ENZYME ACTIVATOR; MESSENGER RNA; OXIDOPAMINE; PROTEIN P35; PROTEIN P39; PROTEIN P67; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL NUCLEUS; ENZYME ACTIVITY; NERVE CELL NECROSIS; NERVE FIBER TRANSECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SUBSTANTIA NIGRA;

ANIMALS; ANTIBODIES; APOPTOSIS; AXOTOMY; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; EPITOPES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MEDIAL FOREBRAIN BUNDLE; MUNC18 PROTEINS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; NEURONS; OXIDOPAMINE; PHOSPHORYLATION; QUINOLINIC ACID; RATS; RNA, MESSENGER; SUBSTANTIA NIGRA; SYMPATHOLYTICS; TAU PROTEINS; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 0034972511     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00376.x     Document Type: Article

References (61)

1. Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death
2. Trophic factors and neuronal survival
3. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5
4. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5
5. Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury
6. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
7. Neuronal death in the development of the vertebrate nervous system
8. Neuron death in vertebrate development: In vivo methods
9. Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5
10. Stereology of arbitrary particles
11. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
12. Stereotaxic electrode placement in the neonatal rat
13. Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra
14. Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins
15. Immunohistochemical localization of CDK5 activator p39 in the rat brain
16. Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract
17. Physiology and pathology of tau protein kinases in relation to Alzheimer's disease
18. Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems
19. Developmental cell death in dopaminergic neurons of the substantia nigra of mice
20. Naturally occurring cell death during postnatal development of the substantia nigra of the rat
21. Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra
22. Apoptotic neuron death in rat substantia nigra induced by striatal excitotoxic injury is developmentally dependent
23. Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain
24. Neuronal cdc2-like kinase
25. cdc2
26. A brain-specific activator of cyclin-dependent kinase 5
27. Structure, function, and regulation of neuronal cdc2-like protein kinase
28. Apoptosis in substantia nigra following developmental striatal excitotoxic injury
29. Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra
30. Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes
31. A family of human cdc2-related protein kinases
32. NeuN, a neuronal specific nuclear protein in vertebrates
33. p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease
34. Cyclin-dependent kinase 5 in Lewy body-like inclusions in anterior horn cells of a patient with sporadic amyotrophic lateral sclerosis
35. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
36. Aberrant tau phosphorylation and neurite retraction during NGF deprivation in PC12 cells
37. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death
38. The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra
39. Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra
40. Cell death during development of the nervous system
41. Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
42. Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)
43. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
44. Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments
45. Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
46. n-Sec1: A neural-specific syntaxin-binding protein
47. Association of neurofilament proteins with neuronal Cdk5 activator
48. cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: Isolation and characterization
49. Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5
50. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ
51. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35
52. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator
53. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
54. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
55. Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: Its sequence and developmental change in brain
56. Expression of p67 (Munc-18), Cdk5, P-NFH and syntaxin during development of the rat cerebellum
57. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
58. NeuN: A useful neuronal marker for diagnostic histopathology
59. Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling