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Volumn 19, Issue 1, 2005, Pages 1-10

Decreased release of the angiogenic peptide vascular endothelial growth factor in alzheimer's disease: Recovering effect with insulin and DHEA sulfate

Author keywords

Aging; Alzheimer's disease; Amyloid peptides; Dehydroepiandrosterone sulfate; Immunity; Insulin; Natural killer cells; Neurodegeneration; Vascular dementia; Vascular endothelial growth factor

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CD16 ANTIGEN; CD56 ANTIGEN; INSULIN; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; PEPTIDE; PRASTERONE SULFATE; VASCULOTROPIN;

EID: 20844441406     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080963     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 0025195769 scopus 로고
    • Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease
    • Perlmutter LS, Chui HC, Saperia D, Athanikar J: Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease. Brain Res 1990;508:13-19.
    • (1990) Brain Res , vol.508 , pp. 13-19
    • Perlmutter, L.S.1    Chui, H.C.2    Saperia, D.3    Athanikar, J.4
  • 2
    • 0027314240 scopus 로고
    • Can a disturbed brain microcirculation cause Alzheimer's disease?
    • De la Torre JC, Mussivand T: Can a disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 1993;15:146-153.
    • (1993) Neurol Res , vol.15 , pp. 146-153
    • De La Torre, J.C.1    Mussivand, T.2
  • 3
    • 0031029508 scopus 로고    scopus 로고
    • Cerebromicrovascular pathology in Alzheimer's disease compared to normal aging
    • De la Torre JC: Cerebromicrovascular pathology in Alzheimer's disease compared to normal aging. Gerontology 1997;43:26-43.
    • (1997) Gerontology , vol.43 , pp. 26-43
    • De La Torre, J.C.1
  • 5
    • 0030452414 scopus 로고    scopus 로고
    • Cerebral vessels in aging and Alzheimer's disease
    • Kalaria RN: Cerebral vessels in aging and Alzheimer's disease. Pharmacol Ther 1996;72:193-214.
    • (1996) Pharmacol Ther , vol.72 , pp. 193-214
    • Kalaria, R.N.1
  • 6
    • 0344146580 scopus 로고    scopus 로고
    • Proinflammatory mediators stimulate neutrophil-directed angiogenesis
    • McCourt M, Wang JH, Sookhai S, Redmond HP: Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch Surg 1999;134:1325-1331.
    • (1999) Arch Surg , vol.134 , pp. 1325-1331
    • McCourt, M.1    Wang, J.H.2    Sookhai, S.3    Redmond, H.P.4
  • 8
    • 0034603509 scopus 로고    scopus 로고
    • A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    • Grammas P: A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease. Neurobiol Aging 2000;21:199-205.
    • (2000) Neurobiol Aging , vol.21 , pp. 199-205
    • Grammas, P.1
  • 9
    • 0032920232 scopus 로고    scopus 로고
    • Mechanism of angiogenesis in the brain
    • Plate KH: Mechanism of angiogenesis in the brain. J Neuropathol Exp Neurol 1999;58:313-320.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 313-320
    • Plate, K.H.1
  • 10
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;59:843-846.
    • (1992) Nature , vol.59 , pp. 843-846
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 11
    • 0029879741 scopus 로고    scopus 로고
    • Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans
    • Krupinski J, Kumar P, Kumar S, Kaluza J: Increased expression of TGF-β1 in brain tissue after ischemic stroke in humans. Stroke 1996;27:852-857.
    • (1996) Stroke , vol.27 , pp. 852-857
    • Krupinski, J.1    Kumar, P.2    Kumar, S.3    Kaluza, J.4
  • 12
    • 0032190580 scopus 로고    scopus 로고
    • Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-β
    • Behzadian MA, Wang X-L, Shabrawey M, Caldwell RB: Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-β. Glia 1998;24:216-225.
    • (1998) Glia , vol.24 , pp. 216-225
    • Behzadian, M.A.1    Wang, X.-L.2    Shabrawey, M.3    Caldwell, R.B.4
  • 13
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 15
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22.
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 16
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 17
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 1992;359:845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 19
    • 0036395643 scopus 로고    scopus 로고
    • Determination of vascular endothelial growth factor (VEGF) in circulating blood: Significance of VEGF in various leucocytes and platelets
    • Werther K, Christensen IJ, Nielsen HJ: Determination of vascular endothelial growth factor (VEGF) in circulating blood: Significance of VEGF in various leucocytes and platelets. Scand J Clin Lab Invest 2002;62:343-350.
    • (2002) Scand J Clin Lab Invest , vol.62 , pp. 343-350
    • Werther, K.1    Christensen, I.J.2    Nielsen, H.J.3
  • 20
    • 10844223041 scopus 로고    scopus 로고
    • Downregulation of vascular endothelial growth factor generation from immune cells in Alzheimer's disease
    • Solerte SB, Fioravanti M: Downregulation of vascular endothelial growth factor generation from immune cells in Alzheimer's disease. Neurobiol Aging 2002;23(suppl 1):S532.
    • (2002) Neurobiol Aging , vol.23 , Issue.1 SUPPL.
    • Solerte, S.B.1    Fioravanti, M.2
  • 21
    • 10844266828 scopus 로고    scopus 로고
    • Human insulin upregulates the release of vascular endothelial growth factor (VEGF) from immune cells in hyperinsulinemic microalbuminuric Type 2 diabetic patients
    • Solerte SB, Fioravanti M: Human insulin upregulates the release of vascular endothelial growth factor (VEGF) from immune cells in hyperinsulinemic microalbuminuric Type 2 diabetic patients. Diabetologia 2002;45(suppl 2):A35.
    • (2002) Diabetologia , vol.45 , Issue.2 SUPPL.
    • Solerte, S.B.1    Fioravanti, M.2
  • 22
    • 0037308174 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
    • Zhu Y, Jin K, Mao XO, Greenberg DA: Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J 2003;17:186-193.
    • (2003) FASEB J , vol.17 , pp. 186-193
    • Zhu, Y.1    Jin, K.2    Mao, X.O.3    Greenberg, D.A.4
  • 23
    • 0036790806 scopus 로고    scopus 로고
    • Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism
    • Svensson B, Peters M, Konig HG, Poppe M, Levkau B, Rothermundt M, Arolt V, Kogel D, Prehn JH: Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J Cereb Blood Flow Metab 2002;22:1170-1175.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1170-1175
    • Svensson, B.1    Peters, M.2    Konig, H.G.3    Poppe, M.4    Levkau, B.5    Rothermundt, M.6    Arolt, V.7    Kogel, D.8    Prehn, J.H.9
  • 25
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia
    • Jin KL, Mao XO, Greenberg DA: Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 2000;97:10242-10247.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10242-10247
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 26
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse B, Moons L, Storkebaum E, Carmeliet P: Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-137.
    • (2001) Nat Genet , vol.28 , pp. 131-137
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3    Carmeliet, P.4
  • 27
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer's disease and vascular dementia
    • Tarkowski E, Issa R, Sjogren M, Wallin A, Blennow K, Tarkowski, Kumar P: Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer's disease and vascular dementia. Neurobiol Aging 2002;23:237-243.
    • (2002) Neurobiol Aging , vol.23 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjogren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski6    Kumar, P.7
  • 28
    • 0038314166 scopus 로고    scopus 로고
    • Impairment of secretory pattern of IGF-I from lymphomononuclear cells in aging and dementia of the Alzheimer's and vascular type
    • Solerte SB, Cerutti N, Mirani M, Ceresini G, Giustina A, Ferrari E, Fioravanti M: Impairment of secretory pattern of IGF-I from lymphomononuclear cells in aging and dementia of the Alzheimer's and vascular type. J Endocrinol Invest 2002;25:47-50.
    • (2002) J Endocrinol Invest , vol.25 , pp. 47-50
    • Solerte, S.B.1    Cerutti, N.2    Mirani, M.3    Ceresini, G.4    Giustina, A.5    Ferrari, E.6    Fioravanti, M.7
  • 31
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Workgroup under the auspices of Department of Healthy and Human services task force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzmann R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Workgroup under the auspices of Department of Healthy and Human services task force on Alzheimer's disease. Neurology 1984;34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzmann, R.4    Price, D.5    Stadlan, E.M.6
  • 32
    • 0027534657 scopus 로고
    • Vascular dementia diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop
    • Roman GC, Tatemichi TK, Erkinjunnti T: Vascular dementia diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250-260.
    • (1993) Neurology , vol.43 , pp. 250-260
    • Roman, G.C.1    Tatemichi, T.K.2    Erkinjunnti, T.3
  • 33
    • 0016137385 scopus 로고
    • Multiinfarct dementia: A cause of mental deterioration in the elderly
    • Hachinski VC, Lassen NA, Marshall J: Multiinfarct dementia: A cause of mental deterioration in the elderly. Lancet 1974;ii:207-210.
    • (1974) Lancet , vol.2 , pp. 207-210
    • Hachinski, V.C.1    Lassen, N.A.2    Marshall, J.3
  • 34
    • 0025801744 scopus 로고
    • Apolipoprotein e genotyping by one-stage PCR
    • Wehham PR, Price WH, Blundell G: Apolipoprotein E genotyping by one-stage PCR. Lancet 1991;ii:1158-1159.
    • (1991) Lancet , vol.2 , pp. 1158-1159
    • Wehham, P.R.1    Price, W.H.2    Blundell, G.3
  • 35
    • 0016823810 scopus 로고
    • Mini Mental State. A practical method for grading the cognitive state of patients for the clinician
    • Folstein M, Folstein S, McHugh PR: Mini Mental State. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.1    Folstein, S.2    McHugh, P.R.3
  • 36
    • 0032889058 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate decreases the interleukin-2 mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer's type
    • Solerte SB, Fioravanti M, Schifino N, Cuzzoni G, Fontana I, Vignati G, Govoni S, Ferrari E: Dehydroepiandrosterone sulfate decreases the interleukin-2 mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer's type. Dement Geriatr Cogn Disord 1999;10:21-27.
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 21-27
    • Solerte, S.B.1    Fioravanti, M.2    Schifino, N.3    Cuzzoni, G.4    Fontana, I.5    Vignati, G.6    Govoni, S.7    Ferrari, E.8
  • 37
    • 0033304495 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I
    • Solerte SB, Fioravanti M, Vignati G, Giustina A, Cravello L, Ferrari E: Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I. J Clin Endocrinol Metab 1999;84:3260-3267.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3260-3267
    • Solerte, S.B.1    Fioravanti, M.2    Vignati, G.3    Giustina, A.4    Cravello, L.5    Ferrari, E.6
  • 38
    • 0034603510 scopus 로고    scopus 로고
    • Hemorheologic changes and overproduction of cytokines from immune cells in mild to moderate dementia of the Alzheimer's type: Adverse effects on cerebromicrovascular system
    • Solerte SB, Ceresini G, Ferrari E, Fioravanti M: Hemorheologic changes and overproduction of cytokines from immune cells in mild to moderate dementia of the Alzheimer's type: Adverse effects on cerebromicrovascular system. Neurobiol Aging 2000;21:271-281.
    • (2000) Neurobiol Aging , vol.21 , pp. 271-281
    • Solerte, S.B.1    Ceresini, G.2    Ferrari, E.3    Fioravanti, M.4
  • 39
    • 0034080888 scopus 로고    scopus 로고
    • Actions and interactions of the IGF system in Alzheimer's disease: Review and hypothesis
    • Lackey BR, Gay SL, Henricks DM: Actions and interactions of the IGF system in Alzheimer's disease: Review and hypothesis. Growth Horm IGF Res 2000;10:1-13.
    • (2000) Growth Horm IGF Res , vol.10 , pp. 1-13
    • Lackey, B.R.1    Gay, S.L.2    Henricks, D.M.3
  • 40
    • 0034672811 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus and cerebellum of normal human and Alzheimer disease brain
    • Jafferali S, Dumont Y, Sotty F, Robitaille Y, Quirion R, Kar S: Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus and cerebellum of normal human and Alzheimer disease brain. Synapse 2000;38:450-459.
    • (2000) Synapse , vol.38 , pp. 450-459
    • Jafferali, S.1    Dumont, Y.2    Sotty, F.3    Robitaille, Y.4    Quirion, R.5    Kar, S.6
  • 42
    • 0025938231 scopus 로고
    • Characterization of immunoreactive insulin-like growth factor I from leukocytes and its regulation by growth hormone
    • Baxter JB, Blalock JE, Weigent DA: Characterization of immunoreactive insulin-like growth factor I from leukocytes and its regulation by growth hormone. Endocrinology 1991;129:1727-1734.
    • (1991) Endocrinology , vol.129 , pp. 1727-1734
    • Baxter, J.B.1    Blalock, J.E.2    Weigent, D.A.3
  • 43
    • 0037379329 scopus 로고    scopus 로고
    • IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism
    • Gruden G, Araf S, Zonca S, Burt D, Thomas S, Gnudi L, Viberti GC: IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism. Kidney Int 2003:63:1249-1255.
    • (2003) Kidney Int , vol.63 , pp. 1249-1255
    • Gruden, G.1    Araf, S.2    Zonca, S.3    Burt, D.4    Thomas, S.5    Gnudi, L.6    Viberti, G.C.7
  • 45
    • 0034839145 scopus 로고    scopus 로고
    • Effect of the Alzheimer amyloid fragment Abeta (25-35) on Akt/PKB kinase and survival of PC12 cells
    • Martin D, Salinas M, Lopez-Valdaliso R, Serrano E, Recuero M, Cuadrado A: Effect of the Alzheimer amyloid fragment Abeta (25-35) on Akt/PKB kinase and survival of PC12 cells. J Neurochem 2001;78:1000-1008.
    • (2001) J Neurochem , vol.78 , pp. 1000-1008
    • Martin, D.1    Salinas, M.2    Lopez-Valdaliso, R.3    Serrano, E.4    Recuero, M.5    Cuadrado, A.6
  • 46
    • 0037124108 scopus 로고    scopus 로고
    • Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection
    • Wei W, Wand X, Kusiak JW: Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection. J Biol Chem 2002;277:17649-17656.
    • (2002) J Biol Chem , vol.277 , pp. 17649-17656
    • Wei, W.1    Wand, X.2    Kusiak, J.W.3
  • 48
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Shiojima I, Bialik A, Fulton D, Lefer D, Sessa W: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Shiojima, I.2    Bialik, A.3    Fulton, D.4    Lefer, D.5    Sessa, W.6
  • 49
    • 20844454418 scopus 로고    scopus 로고
    • Characterization of insulin's multiple signaling pathways in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis
    • Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL: Characterization of insulin's multiple signaling pathways in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 2003;60:275-284.
    • (2003) J Biol Chem , vol.60 , pp. 275-284
    • Jiang, Z.Y.1    He, Z.2    King, B.L.3    Kuroki, T.4    Opland, D.M.5    Suzuma, K.6    Suzuma, I.7    Ueki, K.8    Kulkarni, R.N.9    Kahn, C.R.10    King, G.L.11
  • 50
    • 0031033198 scopus 로고    scopus 로고
    • Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men
    • Khorram O, Vu L, Yen SSC: Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A Biol Sci Med Sci 1997;52:M1-M7.
    • (1997) J Gerontol A Biol Sci Med Sci , vol.52
    • Khorram, O.1    Vu, L.2    Yen, S.S.C.3
  • 51
    • 0030006574 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor 1
    • Rubin J, Wandg H, Tashjian AH Jr, Patterson C: Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor 1. Endocrinology 1996;137:2262-2268.
    • (1996) Endocrinology , vol.137 , pp. 2262-2268
    • Rubin, J.1    Wandg, H.2    Tashjian Jr., A.H.3    Patterson, C.4


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