Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 52, Issue 1, 1997, Pages

  Khorram, Omid ^a,b   Vu, Lan ^a   Yen, Samuel S C ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE SULFATE; SOMATOMEDIN C;

ADULT; AGED; AGING; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HORMONE BLOOD LEVEL; HUMAN; IMMUNE DEFICIENCY; IMMUNOSTIMULATION; MALE; MITOGENESIS; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE;

ANIMALIA;

EID: 0031033198     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/52A.1.M1     Document Type: Article

References (19)

1. Picker U. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 1992; 10:561-91.
2. Ershler WB. The influence of an aging immune system on cancer incidence and progression. J Gerontol Biol Sci 1993;48:B3-7.
3. Staino-Coico L, Darzynkiewicz L, Melmed Z, Weksler MJ. Immunological studies of Aging. IX. Impaired proliferation of T lymphocytes detected in elderly by flow cytometry. Immunology 1994; 132:1788-92.
4. Miller RA. Aging and immune function: cellular and biochemical analyses. Exp Gerontol 1994;21:21-35.
5. Currie MS. Immunosenescence. Compr Ther 1992;18:26-34.
6. Lighthart GJ, VanVlokhoven PC, Schuit HRE, Hijman W. The expanded null-cell compartment in aging: increase in the number of natural killer cells and changes in T cell and NK cell subsets in human blood. Immunology 1986;59:353-7.
7. Krishnaraj R, Blanford G. Age-associated alterations in human natural killer cells. 1. Increased activity as per conventional and kinetic analysis. Clin Immunol Immunopathol 1987;45:268-85.
8. Nagel JE, Collins GD, Adler WH. Spontaneous or natural killer cytotoxicity of K562 erythroleukemic cells in normal patients. Cancer Res 1981;41:2284-8.
9. Riley V, Firzmaurice MA, Regelson W. DHEA and thymus integrity in the mouse. In: Kalimi M, Regelson W, eds. Biologic role of dehydroepiandrosterone (DHEA). Berlin: DeGruyter, 1990:131-55.
10. Regelson W, Loria R, Kalimi M. Dehydroepiandrosterone (DHEA) the "mother steroid." Part 1. Immunologic action. Ann NY Acad Sci 1994;719:553-63.
11. Regelson W, Kalimi M. Dehydroepiandrosterone (DHEA) the multifunctional steroid: effects on the CNS, cell proliferation, metabolic, vascular, clinical and other effects. Ann NY Acad Sci 1994;719: 564-75.
12. Regelson W, Kalimi M. Dehydroepiandrosterone (DHEA): a pleiotropic steroid. How can one steroid do so much? Adv Anti-Aging Med 1996;l:287-317.
13. Loria RM, Inge TH, Cook SS, Szaki AK, Regelson W. Protection against acute lethal viral infection with the native steroid dehydroepiandrosterone (DHEA). J Med Virol 1988;26:301-14.
14. May M, Holmes E, Rogers W, Poth M. Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone. Life Sci 1990;46:1627-31.
15. Lucas JA, Ansar AS, Casey L, Mac Donald PC. Prevention of autoantibody formation and prolonged survival in New Zealand Black/ New Zealand White F1 mice fed dehydroepiandrosterone. J Clin Invest 1985;75:2091-3.
16. Van Vollenhoven RF, McDevitt HO. Studies of treatment of nephritis in NZB/NZW mice with dehydroepiandrosterone. Arthritis Rheum 1992;35:S207.
17. Risdon G, Moore TA, Kumar V, Bennett M. Inhibition of murine natural killer cell differentiation by dehydroepiandrosterone. Blood 1991;78:2387-91.
18. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li G, Ryu S. Altered regulation of IL-6 production with normal aging. J Immunol 1993;150:5219-30.
19. Daynes RA, Dudley DJ, Araneo BA. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur J Immunol 1990;20:793-802.