Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 9, 1999, Pages 3260-3267

  Solerte, S B ^a   Fioravanti, M ^a   Vignati, G ^a   Giustina, A ^a   Cravello, L ^a   Ferrari, E ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FICOLL; INTERLEUKIN 4; PRASTERONE SULFATE; SOMATOMEDIN C; SOMATOSTATIN 14;

ADULT; AGED; AGING; ARTICLE; AUTOCRINE EFFECT; CELL COUNT; CELL ISOLATION; CELL SEPARATION; CYTOKINE PRODUCTION; DENSITY GRADIENT; FEMALE; HORMONE DETERMINATION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOREACTIVITY; MALE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NORMAL HUMAN; PRIORITY JOURNAL;

SAMBUCUS NIGRA CANADENSIS;

EID: 0033304495     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.9.3260     Document Type: Article

References (62)

1. An adrenal-secreted 'androgen:' Dehydroepiandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man
2. Biologic activity of dehydroepiandrosterone sulfate in man
3. Synthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate by the human adrenal
4. 24-hour secretory pattern of dehydroepiandrosterone and dehydroepiandrosterone sulfate
5. A prospective study of dehydroepiandrosterone sulfate, mortality in postmenopausal women
6. Physiological importance of dehydroepiandrosterone
7. Dehydroepiandrosterone (DHEA): A fountain of youth?
8. Hormonal intervention: 'Buffer hormones' or 'state dependency:' The role of dehydroepiandrosterone (DHEA), thyroid hormone, estrogen and hypophysectomy in aging
9. Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA)
10. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin-2 synthesis by helper cells
11. Prevention and reversal of some age-associated changes in immunologic responses by supplemental dehydroepiandrosteronesulfate therapy
12. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factor interleukin 2 and interleukin 4
13. Dehydroepiandrosterone enhances IL-2 production and cytotoxic effector function of human T-cells
14. Effect of dexamethasone and dehydroepiandrosterone in immunosuppressed rats infected with Crytosporidium parvum
15. Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence
16. Cortisol, DHEA-sulfate and natural killer (NK) cell function in the clinical characterization of Alzheimer's disease
17. Dehydroepiandrosteronesulfate (DHEAS) and natural killer immunity: Relationship between in vitro effects and circulating levels in old normal and demented subjects
18. Dehydroepiandrosteronesulfate (DHEAS) decreases the interleukin-2 mediated overactivity of natural killer cell compartment in senile dementia of the Alzheimer's type
19. Enhanced NK cell activity in mice injected with interferon and interferon inducers
20. Enhancement of human natural killer cell activity by interferon
21. Interleukin-2 augments natural killer cell activity
22. Biology of natural killer cells
23. Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor 1 in vitro
24. Replacement of DHEA in aging men and women
25. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men
26. Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity
27. Expression of type I insulin-like growth factor receptors on human peripheral blood mononuclear cells
28. Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the SENIEUR protocol
29. Phenotypic transformation of normal rat kidney cells in a growth-factor-defined medium: Induction by a neuroblastoma-derived transforming growth factor independently of the EGF receptor
30. Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell-line targets
31. Biology and clinical relevance of human natural killer cells
32. Isolation of mononuclear cells and granulocytes from human blood
33. A rapid method for isolation of functional thymus-derived murine lymphocytes
34. High gradient magnetic cell separation with MACS
35. Preservation of cytotoxic function during multi-cycle immunomagnetic cell separations of human NK cells using a new type of magnetic bead
36. Inhibition by cortisol of human natural killer (NK) cell activity
37. Direct suppression of natural killer activity in human peripheral blood leukocyte cultures by glucocorticoids and its modulation by interferon
38. An enzyme-release assay for natural cytotoxicity
39. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantification of natural killer cell activity
40. Inhibition of access of basic somatomedin to membrane receptors and immunobinding sites. A comparison of radioreceptor and radioimmunological somatomedin in native and acidethanol extracted serum
41. Characterization of immunoreactive insulin-like growth factor I from leukocytes and its regulation by growth hormone
42. Production of insulin-like growth factor I and its binding protein by adult rat hepatocytes in primary culture
43. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood
44. Alveolar macrophages release our insulin-like growth factor molecule
45. Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor I
46. Insulin-like growth factor secretion by human B-lymphocytes: A comparison of cells from normal and pygmy subjects
47. Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes
48. Priming of human polymorphonuclear neutrophilic leukocytes by insulin-like growth factor I: Increased phagocytic capacity, complement receptor expression, degranulation, and oxidative burst
49. Distinct subsets of somatostatin receptors on cultured human lymphocytes
50. Inhibitory effect of somatostatin-14 and some analogues on human natural killer cell activity
51. 2 administration on the immune system of aging men and women
52. Enhanced cytotoxic response of natural killer cells to IL-2 in Alzheimer's disease
53. Interleukin-2 and human monocyte activation
54. Effect of growth hormone and insulin-like growth factor I on immunoglobulin production and groth of human B cells
55. Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation
56. Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis
57. 3H) 2-deoxy-glucose uptake, diacylglycerol generation and protein kinase C activation in BC 36-1 myocytes
58. + ratio after one month of treatment with stanazolol in postmenopausal women
59. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men
60. Lymphocyte subsets in the blood: A diagnostic window on the lymphoid system?