메뉴 건너뛰기




Volumn 16, Issue 3, 2005, Pages 141-146

The imidazoquinolines - Mechanism of action and therapeutic potential in HPV-associated disease

Author keywords

HPV associated disease; Imidazoquinolines; Imiquimod; Therapy

Indexed keywords

ALPHA INTERFERON; GUANOSINE DERIVATIVE; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; INTERLEUKIN 12; INTERLEUKIN 6; PLACEBO; RESIQUIMOD; S 27609; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VACCINE;

EID: 20744452800     PISSN: 09574190     EISSN: None     Source Type: Journal    
DOI: 10.1179/095741905X41267     Document Type: Review
Times cited : (6)

References (50)
  • 1
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and non-self by the innate immune system
    • Medzhitov R, Janeway Jr CA. Decoding the patterns of self and non-self by the innate immune system. Science 2002;296:298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 2
    • 3242711262 scopus 로고    scopus 로고
    • Innate sensing of viruses by Toll-like receptors
    • Boehme KW, Compton T. Innate sensing of viruses by Toll-like receptors. J Virol 2004;78:7867-73.
    • (2004) J. Virol. , vol.78 , pp. 7867-7873
    • Boehme, K.W.1    Compton, T.2
  • 3
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 1526-1529
    • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004;303:1526-9.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 4
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reise Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004;303:1529-31.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reise Sousa, C.5
  • 6
    • 2342450044 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    • Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004;50:714-21.
    • (2004) J. Am. Acad. Dermatol. , vol.50 , pp. 714-721
    • Lebwohl, M.1    Dinehart, S.2    Whiting, D.3    Lee, P.K.4    Tawfik, N.5    Jorizzo, J.6
  • 7
    • 2342473348 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from two phase III, randomized, vehicle-controlled studies
    • Geisse J, Caro I, Lindholm J, Golitz L, Stampone P, Owens M. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. J Am Acad Dermatol 2004;50:722-33.
    • (2004) J. Am. Acad. Dermatol. , vol.50 , pp. 722-733
    • Geisse, J.1    Caro, I.2    Lindholm, J.3    Golitz, L.4    Stampone, P.5    Owens, M.6
  • 8
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002; 3:196-200.
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6
  • 10
    • 2442555760 scopus 로고    scopus 로고
    • Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod
    • Schon MP, Wienrich BG, Drewniok C, Bong AB, Eberle J, Geilen CC et al. Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod. J Invest Dermatol 2004;122:1266-76.
    • (2004) J. Invest. Dermatol. , vol.122 , pp. 1266-1276
    • Schon, M.P.1    Wienrich, B.G.2    Drewniok, C.3    Bong, A.B.4    Eberle, J.5    Geilen, C.C.6
  • 11
  • 12
    • 0036456708 scopus 로고    scopus 로고
    • Imiquimod and the imidazoquinolines: Mechanism of action and therapeutic potential
    • Stanley MA. Imiquimod and the imidazoquinolines: mechanism of action and therapeutic potential. Clin Exp Dermatol 2002;27:571-7.
    • (2002) Clin. Exp. Dermatol. , vol.27 , pp. 571-577
    • Stanley, M.A.1
  • 13
    • 0024231126 scopus 로고    scopus 로고
    • Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection
    • [published erratum appears in Antiviral Res 1989;11:215]
    • Harrison CJ, Jenski L, Voychehovski T, Bernstein DI. Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection [published erratum appears in Antiviral Res 1989;11:215]. Antiviral Res 88;10:209-23.
    • Antiviral Res. , vol.88 , Issue.10 , pp. 209-223
    • Harrison, C.J.1    Jenski, L.2    Voychehovski, T.3    Bernstein, D.I.4
  • 14
    • 0024434220 scopus 로고    scopus 로고
    • Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus type 2 infections
    • Bernstein DI, Harrison CJ. Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus type 2 infections. Antimicrob Agents Chemother 89;33:1511-5.
    • Antimicrob. Agents Chemother. , vol.89 , Issue.33 , pp. 1511-1515
    • Bernstein, D.I.1    Harrison, C.J.2
  • 15
    • 0000186554 scopus 로고    scopus 로고
    • Antiviral/immunomodulator R-837 induces α interferon in mice
    • Weeks CE, Reiter MJ. Antiviral/immunomodulator R-837 induces α interferon in mice. J Invest Dermatol 89;93:584.
    • J. Invest. Dermatol. , vol.89 , Issue.93 , pp. 584
    • Weeks, C.E.1    Reiter, M.J.2
  • 18
    • 0031900829 scopus 로고    scopus 로고
    • Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463
    • 98
    • Imbertson LM, Beaurline JM, Couture AM, Gibson SJ, Smith RM, Miller RL et al. Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463. J Invest Dermatol 98;110:734-9.
    • J. Invest. Dermatol. , vol.110 , pp. 734-739
    • Imbertson, L.M.1    Beaurline, J.M.2    Couture, A.M.3    Gibson, S.J.4    Smith, R.M.5    Miller, R.L.6
  • 22
    • 0033540341 scopus 로고    scopus 로고
    • Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod
    • 99
    • Wagner TL, Ahonen CL, Couture AM, Gibson SJ, Miller RL, Smith RM et al. Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol 99;191:10-9.
    • Cell Immunol. , vol.191 , pp. 10-19
    • Wagner, T.L.1    Ahonen, C.L.2    Couture, A.M.3    Gibson, S.J.4    Miller, R.L.5    Smith, R.M.6
  • 23
    • 0036088492 scopus 로고    scopus 로고
    • Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    • Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 2002;3:499.
    • (2002) Nat. Immunol. , vol.3 , pp. 499
    • Jurk, M.1    Heil, F.2    Vollmer, J.3    Schetter, C.4    Krieg, A.M.5    Wagner, H.6
  • 25
    • 0036924110 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod
    • Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, Fuller AE et al. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol 2002;218:74-86.
    • (2002) Cell Immunol. , vol.218 , pp. 74-86
    • Gibson, S.J.1    Lindh, J.M.2    Riter, T.R.3    Gleason, R.M.4    Rogers, L.M.5    Fuller, A.E.6
  • 26
    • 12444341806 scopus 로고    scopus 로고
    • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8
    • Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol 2005;174:1259-68.
    • (2005) J. Immunol. , vol.174 , pp. 1259-1268
    • Gorden, K.B.1    Gorski, K.S.2    Gibson, S.J.3    Kedl, R.M.4    Kieper, W.C.5    Qiu, X.6
  • 27
    • 0031853904 scopus 로고    scopus 로고
    • A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod
    • 98
    • Tyring SK, Arany I, Stanley MA, Tomai MA, Miller RL, Smith MH et al. A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod. J Infect Dis 98;178:551-5.
    • J. Infect. Dis. , vol.178 , pp. 551-555
    • Tyring, S.K.1    Arany, I.2    Stanley, M.A.3    Tomai, M.A.4    Miller, R.L.5    Smith, M.H.6
  • 28
    • 1842578532 scopus 로고    scopus 로고
    • Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model
    • Otero M, Calarota SA, Felber B, Laddy D, Pavlakis G, Boyer JD et al. Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model. Vaccine 2004;22:1782-90.
    • (2004) Vaccine , vol.22 , pp. 1782-1790
    • Otero, M.1    Calarota, S.A.2    Felber, B.3    Laddy, D.4    Pavlakis, G.5    Boyer, J.D.6
  • 29
    • 11144356241 scopus 로고    scopus 로고
    • Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA
    • Zuber AK, Brave A, Engstrom G, Zuber B, Ljungberg K, Fredriksson M et al. Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA. Vaccine 2004;22:1791-8.
    • (2004) Vaccine , vol.22 , pp. 1791-1798
    • Zuber, A.K.1    Brave, A.2    Engstrom, G.3    Zuber, B.4    Ljungberg, K.5    Fredriksson, M.6
  • 30
    • 4344697150 scopus 로고    scopus 로고
    • Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod
    • Palamara F, Meindl S, Holcmann M, Luhrs P, Stingl G, Sibilia M. Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol 2004;173:3051-61.
    • (2004) J. Immunol. , vol.173 , pp. 3051-3061
    • Palamara, F.1    Meindl, S.2    Holcmann, M.3    Luhrs, P.4    Stingl, G.5    Sibilia, M.6
  • 31
    • 0035825571 scopus 로고    scopus 로고
    • Reduction of recurrent HSV disease using imiquimod alone or combined with a glycoprotein vaccine
    • Harrison CJ, Miller RL, Bernstein DI. Reduction of recurrent HSV disease using imiquimod alone or combined with a glycoprotein vaccine. Vaccine 2001;19:1820-6.
    • (2001) Vaccine , vol.19 , pp. 1820-1826
    • Harrison, C.J.1    Miller, R.L.2    Bernstein, D.I.3
  • 34
    • 0034120295 scopus 로고    scopus 로고
    • Intiquimod, a topical immune response modifier, induces migration of Langerhans cells
    • Suzuki H, Wang B, Shivji GM, Toto P, Amerio P, Tomai MA et al. Intiquimod, a topical immune response modifier, induces migration of Langerhans cells. J Invest Dermatol 2000;114:135-41.
    • (2000) J. Invest. Dermatol. , vol.114 , pp. 135-141
    • Suzuki, H.1    Wang, B.2    Shivji, G.M.3    Toto, P.4    Amerio, P.5    Tomai, M.A.6
  • 37
    • 0031886680 scopus 로고    scopus 로고
    • Self-administered topical 5% imiquimod cream for external anogenital warts. Human PapillomaVirus
    • HPV Study Group. 98
    • Edwards L, Ferenczy A, Eron L, Baker D, Owens ML, Fox TL et al. Self-administered topical 5% imiquimod cream for external anogenital warts. HPV Study Group. Human PapillomaVirus. Arch Dermatol 98;134:25-30.
    • Arch. Dermatol. , Issue.134 , pp. 25-30
    • Edwards, L.1    Ferenczy, A.2    Eron, L.3    Baker, D.4    Owens, M.L.5    Fox, T.L.6
  • 38
    • 2942648153 scopus 로고    scopus 로고
    • Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gamma cytokine receptor subunit or JAK-3 deficiency
    • Laffort C, Le Deist F, Favre M, Caillat Zucman S, Radford Weiss I, Debre M et al. Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gamma cytokine receptor subunit or JAK-3 deficiency. Lancet 2004;363:2051-4.
    • (2004) Lancet , vol.363 , pp. 2051-2054
    • Laffort, C.1    Le Deist, F.2    Favre, M.3    Caillat Zucman, S.4    Radford Weiss, I.5    Debre, M.6
  • 39
    • 0033747683 scopus 로고    scopus 로고
    • Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum
    • Hengge UR, Esser S, Schultewolter T, Behrendt C, Meyer T, Stockfleth E et al. Self-administered topical 5% imiquimod for the treatment of common warts and molluscum contagiosum. Br J Dermatol 2000;143:1026-31.
    • (2000) Br. J. Dermatol. , vol.143 , pp. 1026-1031
    • Hengge, U.R.1    Esser, S.2    Schultewolter, T.3    Behrendt, C.4    Meyer, T.5    Stockfleth, E.6
  • 41
    • 0038655505 scopus 로고    scopus 로고
    • Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients
    • Meyer T, Arndt R, Nindl I, Ulrich C, Christophers E, Stockfleth E. Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients. Transpl Int 2003;16:146-53.
    • (2003) Transpl. Int. , vol.16 , pp. 146-153
    • Meyer, T.1    Arndt, R.2    Nindl, I.3    Ulrich, C.4    Christophers, E.5    Stockfleth, E.6
  • 42
    • 4644304377 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of actinic keratosis: Results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology
    • Szeimies RM, Gerritsen MJ, Gupta G, Ortonne JP, Serresi S, Bichel J et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol 2004;51:547-55.
    • (2004) J. Am. Acad. Dermatol. , vol.51 , pp. 547-555
    • Szeimies, R.M.1    Gerritsen, M.J.2    Gupta, G.3    Ortonne, J.P.4    Serresi, S.5    Bichel, J.6
  • 43
    • 0036230613 scopus 로고    scopus 로고
    • The effects of 5% imiquimod cream on high-grade vulval intraepithelial neoplasia
    • Todd RW, Etherington IJ, Luesley DM. The effects of 5% imiquimod cream on high-grade vulval intraepithelial neoplasia. Gynecol Oncol 2002;85:67-70.
    • (2002) Gynecol. Oncol. , vol.85 , pp. 67-70
    • Todd, R.W.1    Etherington, I.J.2    Luesley, D.M.3
  • 44
    • 0036115202 scopus 로고    scopus 로고
    • Treatment of vulvar intraepithelial neoplasia 2/3 with imiquimod
    • Jayne CJ, Kaufman RH. Treatment of vulvar intraepithelial neoplasia 2/3 with imiquimod. J Reprod Med 2002;47:395-8.
    • (2002) J. Reprod. Med. , vol.47 , pp. 395-398
    • Jayne, C.J.1    Kaufman, R.H.2
  • 45
  • 47
  • 48
    • 4143061382 scopus 로고    scopus 로고
    • Imiquimod treatment induces expression of opioid growth factor receptor: A novel tumor antigen induced by interferon-alpha?
    • Urosevic M, Oberholzer PA, Maier T, Hafner J, Laine E, Slade H et al. Imiquimod treatment induces expression of opioid growth factor receptor: a novel tumor antigen induced by interferon-alpha? Clin Cancer Res 2004;10:4959-70.
    • (2004) Clin. Cancer. Res. , vol.10 , pp. 4959-4970
    • Urosevic, M.1    Oberholzer, P.A.2    Maier, T.3    Hafner, J.4    Laine, E.5    Slade, H.6
  • 49
    • 0036046523 scopus 로고    scopus 로고
    • Imiquimod, a topical immune response modifier, in the treatment of cutaneous metastases of malignant melanoma
    • Bong AB, Bonnekoh B, Franke I, Schon MP, Ulrich J, Gollnick H. Imiquimod, a topical immune response modifier, in the treatment of cutaneous metastases of malignant melanoma. Dermatology 2002;205:135-8.
    • (2002) Dermatology , vol.205 , pp. 135-138
    • Bong, A.B.1    Bonnekoh, B.2    Franke, I.3    Schon, M.P.4    Ulrich, J.5    Gollnick, H.6
  • 50
    • 0036053251 scopus 로고    scopus 로고
    • Topical imiquimod eradicates skin metastases of malignant melanoma but fails to prevent rapid lymphogenous metastatic spread
    • Ugurel S, Wagner A, Pfohler C, Tilgen W, Reinhold U. Topical imiquimod eradicates skin metastases of malignant melanoma but fails to prevent rapid lymphogenous metastatic spread. Br J Dermatol 2002;147:621-4.
    • (2002) Br. J. Dermatol. , vol.147 , pp. 621-624
    • Ugurel, S.1    Wagner, A.2    Pfohler, C.3    Tilgen, W.4    Reinhold, U.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.