Cellular Requirements for Cytokine Production in Response to the Immunomodulators Imiquimod and S-27609

Journal of Interferon and Cytokine Research

Volumn 15, Issue 6, 1995, Pages 537-545

  Gibson, Sheila J ^a   Imbertson, Linda M ^a   Wagner, Tamara L ^a   Testerman, Traci L ^a   Reiter, Michael J ^a   Miller, Richard L ^a   Tomai, Mark A ^a  

^a 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO ALPHA,ALPHA,2 TRIMETHYL 1H IMIDAZO[4,5 C]QUINOLIN 1 ETHANOL; ALPHA INTERFERON; CD14 ANTIGEN; CD36 ANTIGEN; CYTOKINE; HLA DR ANTIGEN; IMIDAZOLE DERIVATIVE; IMIQUIMOD; IMMUNOMODULATING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEUCINE METHYL ESTER; LIPOPOLYSACCHARIDE; LYMPHOCYTE ANTIGEN; MONOCLONAL ANTIBODY; POLYINOSINIC POLYCYTIDYLIC ACID; S 27609; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; MONOCYTE; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; ROSETTE FORMING CELL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; AMINOQUINOLINES; ANTIGENS, CD14; ANTIGENS, CD36; CYTOKINES; HLA-DR ANTIGENS; HUMAN; INTERFERON INDUCERS; MONOCYTES;

EID: 0029032284     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.1995.15.537     Document Type: Article

References (31)

1. SIDKY, Y.A., BORDEN, E.C., WEEKS, C.E., REITER, M.J., HATCHER, J.F., and BRYAN, G.T. (1992). Inhibition of murine tumor growth by an interferon inducing imidazoquinolinamine. Cancer Res. 52, 3528-3533.
2. BORDEN, E.C., SIDKY, Y.A., and WEEKS, C.E. (1991). Mechanisms of anti-tumor action of the interferon inducer R-837. Proc. Am. Assoc. Cancer Res. 32,258.
3. MILLER, R.L., IMBERTSON, L.M., REITER, M.J., SCHWARTZMILLER, D.H., PECORE, S.E., and GERSTER, J.F. (1985). Inhibition of herpes simplex virus infection in a guinea pig mode! by S-26308 (abstract). ASM, 26th Interscience Conference on Antimicrobial Agents and Chemotherapy, p. 235.
4. HARRISON, C.J., JENSKI, L., and VOYCHEHOVSKI, T. (1988). Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Res. 10, 209-224.
5. BERNSTEIN, D.I., and HARRISON, C.J. (1989). Effects of the immunomodulating agent R-837 on acute and latent herpes simplex virus type 2 infections. Antimicrob. Agents Chemother. 33, 1511-1515.
6. HARRISON, C.J., STANBERRY, L.R., and BERNSTEIN, D.I. (1991). Effects of cytokines and R-837, a cytokine inducer, on UV-irradiation augmented recurrent genital herpes in guinea pigs. Antiviral Res. 15, 315-322.
7. BERNSTEIN, D.I., MILLER, R.L., and HARRISON, C.J. (1993). Effects of the immunomodulator (imiquimod, R-837) alone and with acyclovir on genital HSV-2 infection in guinea pigs when begun after lesion development. Antiviral Res. 20, 45-55.
8. CHEN, M., GRIFFITH, B.P., LUCIA, H.L., and HSUING, G.D. (1988). Efficacy of S-26308 against guinea pig cytomegalovirus. Antimicrob. Agents Chemother. 32, 678-683.
9. KENDE, M.J., LUPTON, H.W., andCANONICO, P.G. (1988). Treatment of experimental viral infections with immunomodula-tors. Adv. Biosci. 68, 51-63.
10. MILLER, R.L., IMBERTSON, L.M., REITER, M.J., PECORE, S.E., and GERSTER, J.F. (1986). Interferon induction by antiviral S-26308 in guinea pigs (abstract). ASM, 27th Interscience Conference on Antimicrobial Agents and Chemotherapy, p. 168.
11. REITER, M.J., TESTERMAN, T.L., MILLER, R.L., WEEKS, C.E., and TOMAI, M.A. (1994). Cytokine induction in mice by the immunomodulator imiquimod. J. Leuk. Biol. 55, 234-240.
12. GIBSON, S.J., ELROD, S.V., MILLER, R.L., and WEEKS, C.E. (1990). Oral R-837 induces alpha interferon in cynomolgus monkeys (abstract). J. Interferon Res. 10, SI24.
13. WICK, K.A., KVAM, D.C., WEEKS, C.E., DIXON, R.M., HAFSTAD, K., and WITT, P.L. (1991). Oral R-837 induces interferon in healthy volunteers (abstract). Proc. Am. Assoc. Cancer Res. 32, 257.
14. BORDEN, E., WITT, P., KVAM, D., WICK, K., RITCH, P., ANDERSON, T., OWENS, M., SIDKY, Y., and GROSSBERG, S. (1991). An effective oral inducer of interferons in humans (abstract). J. Interferon Res. 11, S92.
15. IMBERTSON, L., WEEKS, C., ADAMS, N., MCCARVILLE, S., HNLEY, D., HOLTZMAN, J., MILLER, R., and KVAM, D. (1992). Induction of antiviral activity and cytokines by oral imiquimod in healthy volunteers (abstract). J. Interferon Res. 12, SI27.
16. WEEKS, C.E., and GIBSON, SJ. (1993). Induction of interferon and other cytokines by imiquimod and its hydroxylated metabolite R-842 in human blood ceils in vitro. J. Interferon Res. 14, 81-85.
17. KONO, T., KONDO, S., PASTORE, S., SHIVJI, G.M., TOMAI, M.A., MCKENZIE, R.C., and SAUDER, D.N. (1993). Effects of a novel immunomodulator, imiquimod, on keratinocyte cytokine gene expression. Lymphokine Cytokine Res. 13,71-76.
18. HAYES, M.P., ENTERLINE, J.C., GERRARD, T.L., and ZOON, K.C. (1991). Regulation of interferon production by human monocytes: requirements for priming for lipopolysaccharide-induced production. J. Leuk. Biol. 50, 176-181.
19. ROBERTS, N.J., DOUGLAS, R.G., SIMMONS, R.M., and DIAMOND, M.E. (1979). Virus-induced interferon production by human macrophages. J. Immunol. 123, 365-369.
20. CEDARBLAD, B., and ALM, G.V. (1990). Infrequent but efficient interferon-a-producing human mononuclear leukocytes induced by herpes simplex virus in vitro studied by inmiuno-plaque and limiting dilution assays. J. Interferon Res. 10,65-73.
21. FELDMAN, M., and HTZGERALD-BOCARSLEY, P.A. (1990). Sequential enrichment and immunocytochemical visualization of human interferon-a-producing cells. J. Interferon Res. 10,435-446.
22. TIMONEN, T.E., SAKSELA, E., VIRTANEN, I., and CANTELL, K. (1980). Natural killer cells are responsible for the interferon production induced in human lymphocytes by tumor cell contact. Eur. J. Immunol. 10, 422-427.
23. WEIGENT, D.A., LANGFORD, M.P., SMITH, E.M., BLALOCK. J.E., and STANTON, G.J. (1981). Human B lymphocytes produce leucocyte interferon after interaction with foreign cells. Infect. Immun. 32,508-512.
24. FITZGERALD-BOCARSLY, P. (1993). Human natural interferon-α producing cells. Pharmacol. Ther. 60, 39-62.
25. ROSZTOCZY, I.N., RAJ, B.K., and PITHA, P.M. (1992). Studies on the in-vitro interferon-inducing activity of the small molecular weight compound R-837 (abstract). J. Interferon Res, 12, S141.
26. DEFORGE, L.E., and REMICK, D.G. (1991). Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood. Biochem. Biophys. Res. Commun. 174, 18-24.
27. TOMAI, M.A., KOTB, M., MAJUMDAR, G., and BEACHEY, E.H. (1990). Superantigenicity of streptococcal M protein. J. Exp. Med. 172, 359-362.
28. THEILE, D.L., KUROSAKA, M., and LIPSKY, P.E. (1983). Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent L-leucine methyl ester. J. Immunol. 131, 2282-2290.
29. ABB, J., ABB, H., and DEINHART, F. (1983). Phenotype of human a-interferon producing leucocytes identified by monoclonal antibodies. Clin. Exp. Immunol. 52, 179-184.
30. HAVELL, E.A., YIP, Y.K., and VILÖEK, J. (1977). Characteristics of human lymphoblastoid (Namalva) interferon. J. Gen. Virol. 38, 51-59.
31. GOBL, A.E., FUNA, K., and ALM, G.V. (1988). Different induction patterns of m-RNA for IFN-α and IFN-p in human mononuclear leukocytes after in vitro challenge with herpes simplex virus-infected fibroblasts and Sendai virus. J. Immunol. 140, 3605-3609.