Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice

British Journal of Pharmacology

Volumn 135, Issue 8, 2002, Pages 2038-2046

  Stephens, R H ^a   O'neill C A ^a   Bennett, J ^b   Humphrey, M ^b   Henry, B ^b   Rowland, M ^a   Warhurst, G ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Digoxin; Etoposide; Intestinal permeability; Mdr1a ( ) mouse; Multidrug resistance associated protein; P glycoprotein; Paclitaxel

Indexed keywords

CALCEIN; DIGOXIN; ETOPOSIDE; GLYCOPROTEIN P; MANNITOL; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PROPRANOLOL; QUINIDINE; VERLUKAST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PENETRATION; DRUG TRANSPORT; GENE; GENE EXPRESSION; ILEUM; INTESTINE; KNOCKOUT MOUSE; MALE; MDR1A GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE; ETOPOSIDE; ILEUM; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MANNITOL; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PROPRANOLOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036246888     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704668     Document Type: Article

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