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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 14, 2005, Pages 3347-3351

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

(11) Koyama, Hiroo a Boueres, Julia K a Miller, Daniel J a Berger, Joel P a MacNaul, Karen L a Wang, Pei Ran a Ippolito, Marc C a Wright, Samuel D a Agrawal, Arun K a Moller, David E a Sahoo, Soumya P a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

Atherosclerosis; Chromane 2 carboxylic acid; PPAR

Indexed keywords

2 METHYLCHROMANE 2 CARBOXYLIC ACID DERIVATIVE; ANTILIPEMIC AGENT; FENOFIBRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN COS1; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HAMSTER; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTILIPEMIC AGENTS; CARBOXYLIC ACIDS; CHROMANS; CRICETINAE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MACACA MULATTA; MALE; MOLECULAR STRUCTURE; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CANIS FAMILIARIS; CRICETINAE;

EID: 20644472234 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.05.028 Document Type: Article

Times cited : (18)

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