Benzoxazinones as PPARγ agonists. Part 1: SAR of three aromatic regions

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 14, 2003, Pages 2359-2362

  Rybczynski, Philip J ^a   Zeck, Roxanne E ^a   Combs, Donald W ^a,b   Turchi, Ignatius ^a   Burris, Thomas P ^a,c   Xu, Jun Z ^a   Yang, Maria ^a   Demarest, Keith T ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUND; BENZOXAZINONE DERIVATIVE; FARGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; REGLITAZAR; ROSIGLITAZONE; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG; ADAPTOR PROTEIN; CELL RECEPTOR; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; LUCIFERASE; OXAZINE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL PROCEDURES; DISEASE MODEL; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GENE INDUCTION; HYPERGLYCEMIA; MOUSE; MOUSE STRAIN; NONHUMAN; PROADIPOCYTE; RAT; STRUCTURE ACTIVITY RELATION; ADIPOCYTE; ANIMAL; AREA UNDER THE CURVE; BIOAVAILABILITY; BIOSYNTHESIS; CELL FRACTIONATION; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; HALF LIFE TIME; HUMAN; IN VITRO STUDY; LIVER MICROSOME; METABOLISM; SYNTHESIS;

ADAPTOR PROTEIN COMPLEX 2; ADIPOCYTES; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; GENE EXPRESSION; HALF-LIFE; HUMANS; HYPERGLYCEMIA; INDICATORS AND REAGENTS; LUCIFERASES; MICE; MICROSOMES, LIVER; OXAZINES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS;

EID: 0038341857     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00401-3     Document Type: Article

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