2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: Highly potent, selective, non-peptidic μ opioid receptor agonists

Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2003, Pages 677-680

  Harrison, Bryce A ^a   Pasternak, Gavril W ^b   Verdine, Gregory L ^a  

^a HARVARD UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIMETHYLTYROSINE DERIVATIVE; ENDOMORPHIN 2; MU OPIATE RECEPTOR AGONIST; PEPTIDE LIBRARY; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; LIGAND BINDING; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; RECEPTOR AFFINITY; STEREOCHEMISTRY;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; CEREBELLUM; CRICETINAE; GUINEA PIGS; HUMANS; LIGANDS; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0037468538     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025608s     Document Type: Article

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27. Statisitcal comparisons for this and subsequent data were determined by performing one-way ANOVA followed by Tukey's post hoc analysis.