Eukaryotic UDP-galactopyranose mutase (GLF Gene) in microbial and metazoal pathogens

Eukaryotic Cell

Volumn 4, Issue 6, 2005, Pages 1147-1154

  Beverley, Stephen M ^a   Owens, Katherine L ^a   Showalter, Melissa ^a   Griffith, Cara L ^a   Doering, Tamara L ^a   Jones, Victoria C ^b   McNeil, Michael R ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTASE; UDP GALACTOPYRANOSE MUTASE; UDP-GALACTOPYRANOSE MUTASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOLOGY; CHEMISTRY; CRYPTOCOCCUS NEOFORMANS; ENZYMOLOGY; ESCHERICHIA COLI; EUKARYOTIC CELL; GENETICS; LEISHMANIA MAJOR; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PHYLOGENY; SEQUENCE HOMOLOGY; TRYPANOSOMA CRUZI; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; CRYPTOCOCCUS NEOFORMANS; ESCHERICHIA COLI; EUKARYOTIC CELLS; INTRAMOLECULAR TRANSFERASES; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

ALGAE; BRUGIA; CAENORHABDITIS ELEGANS; CHLAMYDOMONAS; ESCHERICHIA COLI; EUKARYOTA; FELDMANNIA IRREGULARIS; FILOBASIDIELLA NEOFORMANS; FUNGI; HALOCYNTHIA; LEISHMANIA MAJOR; MAMMALIA; NEMATODA; ONCHOCERCA; PROKARYOTA; PROTOZOA; STRONGYLOIDES; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 20444477920     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.4.6.1147-1154.2005     Document Type: Article

References (35)

1. Ashrafi, K., F. Y. Chang, J. L. Watts, A. G. Fraser, R. S. Kamath, J. Ahringer, and G. Ruvkun. 2003. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421:268-272.
2. Barr, K., R. A. Laine, and R. L. Lester. 1984. Carbohydrate structures of three novel phosphoinositol-containing sphingolipids from the yeast Histoplasma capsulation. Biochemistry 23:5589-5596.
3. Blaxter, M., J. Daub, D. Guiliano, J. Parkinson, and C. Whitton. 2002. The Brugia malayi genome project: expressed sequence tags and gene discovery. Trans. R. Soc. Trop. Med. Hyg. 96:7-17.
4. Chenna, R., H. Sugawara, T. Koike, R. Lopei, T. J. Gibson, D. G. Higgins, and J. D. Thompson. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31:3497-3500.
5. Clarke, B. R., D. Bronner, W. J. Keenleyside, W. B. Severn, J. C. Richards, and C. Whitfield. 1995. Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1. J. Bacteriol. 177:5411-5418.
6. de Lederkremer, R. M., and W. Colli. 1995. Galactofuranose-containing glycoconjugates in trypanosomatids. Glycobiology 5:547-552.
7. Huang, C., and S. J. Turco. 1993. Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani. J. Biol. Chem. 268:24060-24066.
8. Kamath, R. S., A. G. Fraser, Y. Dong, G. Poulin, R. Durbin, M. Gotta, A. Kanapin, N. Le Bot, S. Moreno, M. Sohrmann, D. P. Welchman, P. Zipperlen, and J. Ahringer. 2003. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421:231-237.
9. Kleczka, B., A.-C. Lamerz, H. Bakker, M. Wiese, R. Gerardy-Schahn, and F. H. Routier. 2004. Leishmania major UDP-galactopyranose mutase: characterisation and validation of a potential drug target. Glycobiology 14:abstr. 232.
10. Koplin, R., J. R. Brisson, and C. Whitfield. 1997. UDP-galactofuranose precursor required for formation of the lipopolysaccharide O antigen of Klebsiella pneumoniae serotype O1 is synthesized by the product of the rfbDKPO1 gene. J. Biol. Chem. 272:4121-4128.
11. Kumar, S., K. Tamura, and M. Nei. 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform. 5:150-163.
12. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
13. Latge, J. P., H. Kobayashi, J. P. Debeaupuis, M. Diaquin, J. Sarfati, J. M. Wieruszeski, E. Parra, J. P. Bouchara, and B. Fournet. 1994. Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus. Infect. Immun. 62:5424-5433.
14. Lee, R., D. Monsey, A. Weston, K. Duncan, C. Rithner, and M. McNeil. 1996. Enzymatic synthesis of UDP-galactofuranose and an assay for UDP-galactopyranose mutase based on high-performance liquid chromatography. Anal. Biochem. 242:1-7.
15. Nassau, P. M., S. L. Martin, R. E. Brown, A. Weston, D. Monsey, M. R. McNeil, and K. Duncan. 1996. Galactofuranose biosynthesis in Escherichia coli K-12: identification and cloning of UDP-galactopyranose mutase. J. Bacteriol. 178:1047-1052.
16. Pan, F., M. Jackson, Y. Ma, and M. McNeil. 2001. Cell wall core galactofuran synthesis is essential for growth of mycobacteria. J. Bacteriol. 183:3991-3998.
17. Pedersen, L. L., and S. J. Turco. 2003. Galactofuranose metabolism: a potential target for antimicrobial chemotherapy. Cell Mol. Life Sci. 60:259-266.
18. Previato, J. O., R. Wait, C. Jones, G. A. DosReis, A. R. Todeschini, N. Heise, and L. M. Previato. 2004. Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology. Adv. Parasitol. 56:1-41.
19. Raetz, C. R., and C. Whitfield. 2002. Lipopolysaccharide endotoxins. Annu. Rev. Biochem. 71:635-700.
20. Ryan, K. A., L. A. Garraway, A. Descoteaux, S. J. Turco, and S. M. Beverley. 1993. Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania. Proc. Natl. Acad. Sci. USA 90:8609-8613.
21. Sanders, D. A., A. G. Staines, S. A. McMahon, M. R. McNeil, C. Whitfield, and J. H. Naismith. 2001. UDP-galactopyranose mutase has a novel structure and mechanism. Nat. Struct. Biol. 8:858-863.
22. Scherman, M. S., K. A. Winans, R. J. Stern, V. Jones, C. R. Bertoni, and M. R. McNeil. 2003. Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library. Antimicrob. Agents Chemother. 47:378-382.
23. Simmer, F., C. Moorman, A. M. van der Linden, E. Kuijk, P. V. van den Berghe, R. S. Kamath, A. G. Fraser, J. Ahringer, and R. H. Plasterk. 2003. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLOS Biol. 1:E12.
24. Soltero-Higgin, M., E. E. Carlson, T. D. Gruber, and L. L. Kiessling. 2004. A unique catalytic mechanism for UDP-galactopyranose mutase. Nat. Struct. Mol. Biol. 11:539-543.
25. Soltero-Higgin, M., E. E. Carlson, J. H. Phillips, and L. L. Kiessling. 2004. Identification of inhibitors for UDP-galactopyranose mutase. J. Am. Chem. Soc. 126:10532-10533.
26. Späth, G. F., L. Epstein, B. Leader, S. M. Singer, H. A. Avila, S. J. Turco, and S. M. Beverley. 2000. Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major. Proc. Natl. Acad. Sci. USA 97:9258-9263.
27. Stevenson, G., K. Andrianopoulos, M. Hobbs, and P. R. Reeves. 1996. Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid. J. Bacteriol. 178:4885-4893.
28. Tangallapally, R. P., R. Yendapally, R. E. Lee, K. Hevener, V. C. Jones, A. J. Lenaerts, M. R. McNeil, Y. Wang, S. Franzblau, and R. E. Lee. 2004. Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. J. Med. Chem. 47:5276-5283.
29. Trejo, A. G., G. J. Chittenden, J. G. Buchanan, and J. Baddiley. 1970. Uridine diphosphate alpha-D-galactofuranose, an intermediate in the biosynthesis of galactofuranosyl residues. Biochem. J. 117:637-639.
30. Vaishnav, V. V., B. E. Bacon, M. O'Neill, and R. Cherniak. 1998. Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67. Carbohydr. Res. 306:315-330.
31. Weller, C. T., M. McConville, and S. W. Homans. 1994. Solution structure and dynamics of a glycoinositol phospholipid (GIPL-6) from Leishmania major. Biopolymers 34:1155-1163.
32. Weston, A., R. J. Stern, R. E. Lee, P. M. Nassau, D. Monsey, S. L. Martin, M. S. Scherman, G. S. Besra, K. Duncan, and M. R. McNeil. 1997. Biosynthetic origin of mycobacterial cell wall galactofuranosyi residues. Tuber. Lung Dis. 78:123-131.
33. Wylie, T., J. C. Martin, M. Dante, M. D. Mitreva, S. W. Clifton, A. Chinwalla, R. H. Waterston, R. K. Wilson, and J. P. McCarter. 2004. Nematode. net: a tool for navigating sequences from parasitic and free-living nematodes. Nucleic Acids Res. 32(Database issue):D423-D426.
34. Zhang, K., T. Barron, S. J. Turco, and S. M. Beverley. 2004. The LPG1 gene family of Leishmania major. Mol. Biochem. Parasitol. 136:11-23.
35. Zufferey, R., S. Allen, T. Barron, D. R. Sullivan, P. W. Denny, I. C. Almeida, D. F. Smith, S. J. Turco, M. A. Ferguson, and S. M. Beverley. 2003. Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major. J. Biol. Chem. 278:44708-44718.