Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI)

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 14, 2005, Pages 4408-4424

  Bondebjerg, Jon ^a   Fuglsang, Henrik ^a   Valeur, Kirsten Rosendal ^a   Kaznelson, Dorte Wissing ^a   Hansen, Johnny Arnsdorf ^a   Pedersen, René Orup ^a   Krogh, Berit Olsen ^a   Jensen, Bo Skaaning ^a   Lauritzen, Conni ^b   Petersen, Gitte ^b   Pedersen, John ^b   Nærum, Lars ^a  

^a Arpida Ltd   (Switzerland)

^b Prozymex A/S   (Denmark)

Author keywords

Human dipeptidyl peptidase I; Inflammation; Protease inhibitors; Semicarbazides

Indexed keywords

DIPEPTIDYL PEPTIDASE I; ENZYME INHIBITOR; SEMICARBAZIDE DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME METABOLISM; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDYL PEPTIDASE I; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; PROTEASE INHIBITORS; RATS; SEMICARBAZIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20444455128     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.048     Document Type: Article

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