Antisense oligodeoxynucleotides against the MOR-1 clone alter weight and ingestive responses in rats

Brain Research

Volumn 719, Issue 1-2, 1996, Pages 78-84

  Leventhal, L ^a   Cole, J L ^a   Rossi, G C ^b   Pan, Y X ^b   Pasternak, G W ^b   Bodnar, R J ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Angiotensin II; Glucoprivation; Morphine analgesia; Opioid; Opioid receptor

Indexed keywords

ANGIOTENSIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; MORPHINE; MU OPIATE RECEPTOR; RECEPTOR SUBTYPE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029992173     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00089-3     Document Type: Article

References (69)

1. Adams, J.U., Chen, X., DeRiel, J.K., Adler, M.W. and Liu-Chen, L.Y., Intracerebroventricular treatment with an antisense oligodeoxynucleotide to kappa-opioid receptors inhibited kappa-agonist-induced analgesia in rats, Brain Res., 667 (1994) 129-132.
2. Akabayashi, A., Koenig, J.I., Watanabe, Y., Alexander, J.T. and Leibowitz, S.F., Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain, Proc. Natl. Acad. Sci. USA, 91 (1994) 10375-10379.
3. Akabayashi, A., Wahlstedt, C., Alexander, J.T. and Leibowitz, S.F., Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligodeoxynucleotides suppresses feeding behavior and insulin secretion, Mol. Brain Res., 21 (1994) 55-61.
4. Arjune, D., Standifer, K.M., Pasternak, G.W. and Bodnar, R.J., Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions, Brain Res., 535 (1990) 101-109.
5. Bakshi, V.P. and Kelley, A.E., Feeding induced by opioid stimulation of the ventral striatum: role of opioid receptor subtypes, J. Pharmacol. Exp. Ther., 265 (1993) 1253-1260.
6. Beczkowska, I.W. and Bodnar, R.J., Mediation of insulin hyperphagia by specific central opiate receptor antagonists, Brain Res., 547 (1991) 315-318.
7. Beczkowska, I.W., Bowen, W.D. and Bodnar, R.J., Central opioid receptor subtype antagonists differentially alter sucrose and deprivation-induced water intake in rats, Brain Res., 589 (1992) 291-301.
8. Beczkowska, I.W., Koch, J.E., Bostock, M.E., Leibowitz, S.F. and Bodnar, R.J., Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats, Brain Res., 618 (1993) 261-270.
9. Bilsky, E.J., Bernstein, R.N., Pasternak, G.W., Hruby, V.J., Patel, D., Porreca, F. and Lai, J., Selective inhibition of [D-Ala2,Glu4] deltorphin antinociception by supraspinal, but not spinal administration of an antisense oligodeoxynucleotides to an opioid delta receptor, Life Sci., 55 (1994) PL37-43.
10. Bunzow, J.R., Saez, C., Mortrud, M., Bouvier, C., Williams, J.T., Low, M. and Grandy, D.K., Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa receptor type, FEBS Lett., 347 (1994) 284-288.
11. Chen, X.H., Adams, J.U., Geller, E.B., DeRiel, J.K., Adler, M.W. and Liu-Chen, L.Y., An antisense oligodeoxynucleotide to mu-opioid receptors inhibits mu-opioid receptor agonist-induced analgesia in rats, Eur. J. Pharmacol., 275 (1995) 105-108.
12. Chen, Y., Fan, Y., Liu, J., Mestek, A., Tian, M., Kozak, C.A. and Yu, L., Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family, FEBS Lett., 347 (1994) 279-283.
13. Chen, Y., Mestek, A., Liu, J., Hurley, A. and Yu, L., Molecular cloning and functional expression of a mu-opioid receptor from rat brain, Mol. Pharmacol., 44 (1993) 8-12.
14. Chien, C.C., Brown, G.P., Pan, Y.X. and Pasternak, G.W., Blockade of U50488H analgesia by antisense oligodeoxynucleotides to a kappa opioid receptor, Eur. J. Pharmacol., 253 (1994) R7-8.
15. Cole, J.L., Leventhal, L., Pasternak, G.W., Bowen, W.D. and Bodnar. R.J., Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats, Brain Res., 678 (1995) 168-176.
16. Czech, D.A., Blake, M.J. and Stein, E.A., Drinking behavior is modulated by CNS administration of opioids, Appetite, 5 (1984) 15-24.
17. Evans, C., Keith, D., Morrison, H., Magendzo, K. and Edwards, R., Cloning of a delta-opioid receptor by functional expression, Science, 258 (1992) 1952-1955.
18. Fukuda, K., Kato, S., Mori, K., Nishi, M. and Takeshima, H., Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes, FEBS Lett., 327 (1993) 311-314.
19. Fukuda, K., Kato, S., Mori, K., Nishi, M., Takeshima, H., Iwabe, N., Miyata, T., Houtani, T. and Siguimoti, T., cDNA cloning and regional distribution of a novel member of the opioid receptor family, FEBS Lett., 343 (1994) 42-46.
20. Glass, M.J., Hahn, B., Joseph, A. and Bodnar, R.J., Central opioid receptor subtype mediation of isoproterenol-induced drinking in rats, Brain Res., 657 (1994) 310-314.
21. Gosnell, B.A., Levine, A.S. and Morley, J.E., The stimulation of food intake by selective agonists of mu, kappa and delta opioid receptors, Life Sci., 38 (1986) 1081-1088.
22. Hawkins, M.F., Cubic, B., Baumeister, A.A. and Bartin, C., Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in rats, Brain Res., 584 (1992) 261-265.
23. Islam, A.K. and Bodnar, R.J., Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats. Brain Res., 508 (1990) 293-296.
24. Keith, D., Jr., Maung, T., Anton, B. and Evans, C., Isolation of cDNA clones homologous to opioid receptors, Regul. Peptides, 54 (1994) 143-144.
25. Kieffer, B., Befort, K., Gareiaux-Ruff, C. and Hirth, C., The delta-opioid receptor: isolation of cDNA by expression cloning and pharmacological characterization, Proc. Natl. Acad. Sci. USA, 89 (1992) 12048-12052.
26. Knapp, R.J., Malatynska, E., Collins, N., Fang, L., Wang, J.Y., Hruby, V.J., Roeske, W.R. and Yamamura, H.I., Molecular biology and pharmacology of cloned opioid receptors, FASEB J., 9 (1995) 516-525.
27. Koch, J.E. and Bodnar, R.J., Involvement of mu-1 and mu-2 opioid receptor subtypes in tail-pinch feeding in rats, Physiol. Behav., 53 (1993) 603-605.
28. Koch, J.E. and Bodnar, R.J., Selective alterations in macronutrient intake of food-deprived or glucoprivic rats by centrally-administered opioid receptor subtype antagonists in rats, Brain Res., 657 (1994) 191-201.
29. Kozak, C.A., Filie, J., Adamson, M.C., Chen, Y. and Yu, L., Murine chromosomal location of the mu and kappa opioid receptor genes, Genomics, 21 (1994) 659-661.
30. Lachowicz, J.E., Shen, Y., Monsma, F.J., Jr. and Sibley, D.R., Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family, J. Neurochem., 64 (1995) 34-40.
31. Lai, J., Bilsky, E.J., Bernstein, R.N., Rothman, R.B., Pasternak, G.W. and Porreca, F., Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal antinociceptive effects of [D-Ala2,Glu4]deltorphin, Regul. Peptides, 54 (1994) 159-160.
32. Lai, J., Bilsky, E.J., Rothman, R.B. and Porreca, F., Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta2-agonist antinociception, Neuroreport, 5 (1994) 1049-1052.
33. Leventhal, L., Kirkham, T.C., Cole, J.L. and Bodnar, R.J., Selective actions of central mu and kappa opioid antagonists upon sucrose intake in sham-feeding rats, Brain Res., 685 (1995) 205-210.
34. Levine, A.S., Grace, M. and Billington, C.J., B-funaltrexamine (B-FNA) decreases deprivation and opioid-induced feeding, Brain Res., 562 (1991) 281-284.
35. Mann, P.E., Pasternak, G.W., Hahn, E.F., Curreri, G., Lubin, E. and Bodnar, R.J., Comparison of chronic naloxone and naloxonazine effects upon food intake and body weight maintainance in rats, Neuropharmacology, 27 (1988) 349-355.
36. Min, B.H., Augustin, L.B., Felsheim, R.F., Fuchs, J.A. and Loh, H.H., Genomic structure and analysis of promoter sequence of a mouse mu opioid receptor gene, Proc. Natl. Acad. Sci. USA, 91 (1994) 9081-9085.
37. Mollereau, C., Parmentier, M., Mailleux, P., Butour, J.L., Moisand, C., Chalon, P., Caput, D., Vassart, G. and Meunnier, J.C., ORL-1, a novel member of the opioid family: cloning, functional expression and localization, FEBS Lett., 341 (1994) 33-38.
38. Morley, J.E., Levine, A.S., Yim, G.K.W. and Lowy, M.T., Opioid modulation of appetite, Neurosci. Biobehav. Rev., 7 (1983) 281-305.
39. Pan, Y.X., Cheng, J. and Pasternak, G.W., Isolation and characterization of a kappa3 related opioid receptor, Regul. Peptides, 54 (1994) 217-218.
40. Pan, Y.X., Cheng, J., Xu, J., Rossi, G., Jacobson, E., Ryan-Moro, J., Brooks, A.I., Dean, G.E., Standifer, K.M. and Pasternak, G.W., Cloning and functional characterization through antisense mapping of a kappa3-related opioid receptor, Mol. Pharmacol., 47 (1995) 1180-1188.
41. Papadouka, V. and Carr, K.D., The role of multiple opioid receptors in the maintainance of stimulation-induced feeding, Brain Res., 639 (1994) 42-48.
42. Pasternak, G.W., Pharmacological mechanisms of opioid analgesics, Clin. Neuropharmacol., 16 (1993) 1-18.
43. Pasternak, G.W. and Standifer, K.M., Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology, Trends Pharmacol. Sci., 16 (1995) 344-350.
44. Reisine, T. and Bell, G.I., Molecular biology of opioid receptors, Trends Neurosci., 16 (1993) 506-510.
45. Rossi, G.C., Leventhal, L., Pan, Y.-X., Cole, J., Su, W., Bodnar, R.J. and Pasternak, G.W., Differential inhibition of morphine and morphine-6beta-glucuronide antinociception in the rat by antisense oligodeoxynucleotides against MOR-1, J. Pharmacol. Exp. Ther. (1996) in review.
46. Rossi, G.C., Pan, Y.X., Brown, G.P. and Pasternak, G.W., Antisense mapping the MOR-1 receptor: evidence for alternative splicing and a novel morphine-6Beta-glucuronide receptor, FEBS Lett., 369 (1995) 192-196.
47. Rossi, G., Pan, Y.X., Cheng, J. and Pasternak, G.W., Blockade of morphine analgesia by an antisense oligodeoxynucleotide against the mu receptor, Life Sci., 54 (1994) PL375-379.
48. Rossi, G.C., Standifer, K.M. and Pasternak, G.W., Differential blockade of morphine and morphine-6B-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats, Neurosci. Lett., 198 (1995) 99-102.
49. Ruegg, H., Hahn, B., Koch, J.E. and Bodnar, R.J., Differential modulation of angiotensin II and hypertonic saline-induced drinking by opioid receptor subtype antagonists in rats, Brain Res., 635 (1994) 203-210.
50. Sanger, D.J. and McCarthy, P.S., Differential effects of morphine on food and water intake in food deprived and freely feeding rats, Psychopharmacology, 72 (1980) 103-106.
51. Simone, D.A., Bodnar, R.J., Goldman, E.J. and Pasternak, G.W., Involvement of opioid receptor subtypes in rat feeding behavior, Life Sci., 36 (1985) 829-833.
52. Standifer, K.M., Chien, C.C., Wahlstedt, C., Brown, G.P. and Pasternak, G.W., Selective loss of delta opioid analgesia and binding by oligodeoxynucleotides to a delta opioid receptor, Neuron, 12 (1994) 805-810.
53. Standifer, K.M., Jenab, S., Su, W., Chien, C.-C., Pan, Y.-X., Inturrisi, C.E. and Pasternak, G.W., Antisense oligodeoxynucleotides to the cloned receptor, DOR-1: uptake, stability and regulation of gene expression, J. Neurochem., 65 (1995) 1981-1987.
54. Stanley, B.G., Lanthier, D. and Leibowitz, S.F., Multiple brain sites sensitive to feeding stimulation by opioid agonists: a cannula-mapping study, Pharmacol. Biochem. Behav., 31 (1989) 825-832.
55. Thompson, R.C., Mansour, A., Akil, H. and Watson, S.J., Cloning and pharmacological characterization of a rat mu opioid receptor, Neuron, 11 (1993) 903-913.
56. Tseng, L.F., Collins, K.A. and Kampine, J.P., Antisense oligodeoxynucleotides to a delta-opioid receptor selectively blocks the spinal antinociception induced by delta-, but not mu- or kappa-opioid receptor agonists in the mouse, Eur. J. Pharmacol., 258 (1994) R1-3.
57. Uhl, G.R., Childers, S.R. and Pasternak, G.W., An opiate receptor gene family reunion, Trends Neurosci., 17 (1994) 89-93.
58. Ukai, M. and Holtzman, S.G., Effects of beta-funaltrexamine on ingestive behaviors in the rat, Eur. J. Pharmacol., 153 (1988) 161-165.
59. Ukai, M. and Holtzman, S.G., Effects of intrahypothalamic administration of opioid peptides selective for mu, kappa and delta receptors on different schedules of water intake in rats, Brain Res., 459 (1988) 275-281.
60. Wahlestedt, C., Antisense oligodeoxynucleotide strategies in neuropharmacology, Trends Pharmacol. Sci., 15 (1994) 42-46.
61. Wahlestedt, C., Pich, E.M., Koob, G.F., Yee, F. and Heilig, M., Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides, Science, 260 (1993) 528-531.
62. Wang, J.B., Johnson, P.S., Imai, Y., Persico, A.M., Ozenberger, B.A., Eppler, C.M. and Uhl, G.R., cDNA cloning of an orphan opiate receptor gene family member and its splice variant, FEBS Lett., 348 (1994) 75-79.
63. Wang, J.B., Johnson, P.S., Persico, A.M., Hawkins, A.L., Griffin, C.A. and Uhl, G.R., Human mu opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment, FEBS Lett., 338 (1994) 217-222.
64. Wang, J.-B., Mei, Y., Eppler, C.M., Gregor, P., Spivak, C.E. and Uhl, G.R., Mu opiate receptor: cDNA cloning and expression, Proc. Natl. Acad. Sci. USA, 90 (1993) 10230-10234.
65. Wick, M.J., Minnerath, S.R., Lin, X., Elde, R., Law, P.-Y. and Loh, H.H., Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned, mu, delta and kappa opioid receptors, Mol. Brain Res., 27 (1994) 37-44.
66. Yakovlev, A.G., Krueger, K.E. and Faden, A.I., Structure and expression of a rat kappa opioid receptor gene, J. Biol. Chem., 270 (1995) 6421-6424.
67. Yasuda, K., Raynor, K., Kong, H., Breder, C., Takeda, J., Reisine, T. and Bell, G., Cloning and functional comparison of kappa and delta opioid receptors from mouse brain, Proc. Natl. Acad. Sci. USA, 90 (1993) 6736-6740.
68. Zastawny, R.L., George, S.R., Nguyen, T., Cheng, R., Tsatsos, J., Briones-Urbina, R. and O'Dowd, B.F., Cloning, characterization and distribution of a mu-opioid receptor in rat brain, J. Neurochem., 62 (1994) 2099-2105.
69. Zhu, J., Chen, C., Xue, J.-C., Kunapuli, S., Deriel, J.K. and Liu-Chen, L.-Y., Cloning of a human kappa opioid receptor from the brain, Life Sci., 56 (1995) PL201-PL207.