P2 receptors are involved in the mediation of motivation-related behavior

Purinergic Signalling

Volumn 1, Issue 1, 2004, Pages 21-29

  Krügel, Ute ^a   Spies, Oliver ^a   Regenthal, Ralf ^a   Illes, Peter ^a   Kittner, Holger ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Behavior; EEG; Microdialysis; P1 receptors; P2 receptors

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; GLUTAMINE; PURINE P2 RECEPTOR; PURINE P2Y1 RECEPTOR;

ANIMAL BEHAVIOR; BRAIN FUNCTION; DOPAMINE RELEASE; DOPAMINERGIC ACTIVITY; EXTRAPYRAMIDAL SYSTEM; FEEDING BEHAVIOR; FOOD DEPRIVATION; GABAERGIC TRANSMISSION; IN VIVO STUDY; LIMBIC CORTEX; LOCOMOTION; MESENCEPHALON; NERVE FUNCTION; NERVE STIMULATION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; REVIEW;

EID: 20444416015     PISSN: 15739538     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11302-004-4745-4     Document Type: Review

References (142)

1. M Williams MF Jarvis 2000 Purinergic and pyrimidinergic receptors as potential drug targets Biochem Pharmacol 59 1173-1185
2. RA North 2004 P2X3 receptors and peripheral pain mechanisms J Physiol 554 301-308
3. PJ Richardson SJ Brown 1987 ATP release from affinity-purified rat cholinergic nerve terminals J Neurochem 48 622-630
4. EM Silinsky 1975 On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals J Physiol 247 145-162
5. G Burnstock 1986 Purines and cotransmitters in adrenergic and cholinergic neurones Prog Brain Res 68 193-203
6. RA Cunha ES Vizi JA Ribeiro AM Sebastiao 1996 Preferential release of ATP and its extracellular catabolism as a source of adenosine upon high- but not low-frequency stimulation of rat hippocampal slices J Neurochem 67 2180-2187
7. ES Vizi SD Liang B Sperlagh 1997 Studies on the release and extracellular metabolism of endogenous ATP in rat superior cervical ganglion: Support for neurotransmitter role of ATP Neuroscience 79 893-903
8. B Sperlagh G Hasko Z Nemeth ES Vizi 1998 ATP released by LPS increases nitric oxide production in raw 264.7 macrophage cell line via P2Z/P2X7 receptors Neurochem Int 33 209-215
9. CG Craig TD White 1992 Low-level N-methyl-d-aspartate receptor activation provides a purinergic inhibitory threshold against further N-methyl-d-aspartate-mediated neurotransmission in the cortex J Pharmacol Exp Ther 260 1278-1284
10. CG Craig TD White 1993 NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide Neurosci Lett 158 167-169
11. RW Gereau PJ Conn 1994 Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism Neuron 12 1121-1129
12. PA Rosenberg Y Li 1995 Adenylyl cyclase activation underlies intracellular cyclic AMP accumulation, cyclic AMP transport, and extracellular adenosine accumulation evoked by beta-adrenergic receptor stimulation in mixed cultures of neurons and astrocytes derived from rat cerebral cortex Brain Res 692 227-232
13. P Ballerini MP Rathbone P Iorio Di 1996 Rat astroglial P2Z (P2X7) receptors regulate intracellular calcium and purine release NeuroReport 7 2533-2537
14. H Franke U Krugel R Schmidt 2001 P2 receptor-types involved in astrogliosis in vivo Br J Pharmacol 134 1180-1189
15. ES Vizi G Hasko AI Levey B Sperlagh 2001 Role of endogenous ATP in the role of pro- and antiinflammatory mediator production Drug Dev Res 53 117-125
16. H Zimmermann 2000 Extracellular metabolism of ATP and other nucleotides Naunyn-Schmiedeberg's Arch Pharmacol 362 299-309
17. RA Cunha 2001 Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: Different roles, different sources and different receptors Neurochem Int 38 107-125
18. S Latini F Pedata 2001 Adenosine in the central nervous system: Release mechanisms and extracellular concentrations J Neurochem 79 463-484
19. CHV Hoyle G Burnstock 1991 ATP receptors and their physiological roles TW Stone (ed.) Adenosine in the Nervous System London: Academic Press 41-76
20. V Ralevic G Burnstock 1998 Receptors for purines and pyrimidines Pharmacol Rev 50 413-492
21. G Hollopeter HM Jantzen D Vincent 2001 Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 6817 202-207
22. Y Bogdanov A Rubino G Burnstock 1998 Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart Life Sci 62 697-703
23. G Burnstock 2001 Purine-mediated signalling in pain and visceral perception Trends Pharmacol Sci 22 182-188
24. W Norenberg P Illes 2000 Neuronal P2X receptors: Localisation and functional properties Naunyn-Schmiedeberg's Arch Pharmacol 362 324-339
25. DJ Moore JK Chambers JP Wahlin 2001 Expression pattern of human P2Y receptor subtypes: A quantitative reverse transcription-polymerase chain reaction study Biochim Biophys Acta 1521 107-119
26. D Moore J Chambers H Waldvogel 2000 Regional and cellular distribution of the P2Y(1) purinergic receptor in the human brain: Striking neuronal localisation J Comp Neurol 421 374-384
27. B Sperlagh ES Vizi 1991 Effect of presynaptic P2 receptor stimulation on transmitter release J Neurochem 56 1466-1470
28. MA Majid F Okajima Y Kondo 1992 Characterization of ATP receptor which mediates norepinephrine release in PC12 cells Biochim Biophys Acta 1136 283-289
29. C Allgaier F Pullmann A Schobert 1994 P2 purinoceptors modulating noradrenaline release from sympathetic neurons in culture Eur J Pharmacol 252 R7-R8
30. I Kugelgen von K Kurz B Bultmann 1994 Presynaptic modulation of the release of the co-transmitters noradrenaline and ATP Fundam Clin Pharmacol 8 207-213
31. H Koch I Kugelgen von K Starke 1997 P2-receptor-mediated inhibition of noradrenaline release in the rat hippocampus Naunyn-Schmiedeberg's Arch Pharmacol 355 707-715
32. I Kugelgen von H Koch K Starke 1997 P2-receptor-mediated inhibition of serotonin release in the rat brain cortex Neuropharmacology 36 1221-1227
33. RA Barraco C Clough-Helfman BP Goodwin GF Anderson 1995 Evidence for presynaptic adenosine A2a receptors associated with norepinephrine release and their desensitization in the rat nucleus tractus solitarius J Neurochem 65 1604-1611
34. AU Trendelenburg R Bultmann 2000 P2 receptor-mediated inhibition of dopamine release in rat neostriatum Neuroscience 96 249-252
35. I Kugelgen von C Allgaier A Schobert K Starke 1994 Co-release of noradrenaline and ATP from cultured sympathetic neurons Neuroscience 61 199-202
36. S Koizumi K Inoue 1997 Inhibition by ATP of calcium oscillations in rat cultured hippocampal neurones Br J Pharmacol 122 51-58
37. V Mendoza-Fernandez RD Andrew C Barajas-Lopez 2000 ATP inhibits glutamate synaptic release by acting at P2Y receptors in pyramidal neurons of hippocampal slices J Pharmacol Exp Ther 293 172-179
38. SD Jeftinija KV Jeftinija 1998 ATP stimulates release of excitatory amino acids from cultured Schwann cells Neuroscience 82 927-934
39. BS Khakh G Henderson 1998 ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain Mol Pharmacol 54 372-378
40. T Nakatsuka JG Gu 2001 ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord J Neurosci 21 6522-6531
41. FA Edwards 1996 Features of P2X receptor-mediated synapses in the rat brain: Why doesn't ATP kill the postsynaptic cell? Ciba Found Symp 198 278-286
42. BB Fredholm TV Dunwiddie 1988 How does adenosine inhibit transmitter release? Trends Pharmacol Sci 9 130-134
43. TV Dunwiddie L Diao WR Proctor 1997 Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus J Neurosci 17 7673-7682
44. M Kukley P Stausberg G Adelmann 2004 Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2′-3′- O -(4-benzoylbenzoyl)-ATP J Neurosci 24 7128-7139
45. YX Zhang H Yamashita T Ohshita 1995 ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum Brain Res 691 205-212
46. KA Jacobson MF Jarvis M Williams 2002 Purine and pyrimidine (P2) receptors as drug targets J Med Chem 45 4057-4093
47. G Lambrecht 2000 Agonists and antagonists acting at P2X receptors: Selectivity profiles and functional implications Naunyn-Schmiedeberg's Arch Pharmacol 362 340-350
48. R Frohlich S Boehm P Illes 1996 Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons Eur J Pharmacol 315 255-261
49. L Motin MR Bennett 1995 Effect of P2-purinoceptor antagonists on glutamatergic transmission in the rat hippocampus Br J Pharmacol 115 1276-1280
50. M Okada Y Kawata T Murakami 1999 Interaction between purinoceptor subtypes on hippocampal serotonergic transmission using in vivo microdialysis Neuropharmacology 38 707-715
51. L Heimer DS Zahm L Churchill 1991 Specificity in the projection patterns of accumbal core and shell in the rat Neuroscience 41 89-125
52. SR Sesack VM Pickel 1992 Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area J Comp Neurol 320 145-160
53. WA Carlezon Jr RA Wise 1996 Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex J Neurosci 16 3112-3122
54. DS Zahm L Heimer 1988 Ventral striatopallidal parts of the basal ganglia in the rat: I. Neurochemical compartmentation as reflected by the distributions of neurotensin and substance P immunoreactivity J Comp Neurol 272 516-535
55. L Zaborszky WE Cullinan 1992 Projections from the nucleus accumbens to cholinergic neurons of the ventral pallidum: A correlated light and electron microscopic double-immunolabeling study in rat Brain Res 570 92-101
56. U Krugel H Kittner P Illes 1999 Adenosine 5′-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo Neurosci Lett 265 49-52
57. U Krugel H Kittner H Franke P Illes 2001 Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo Neuropharmacology 40 1084-1093
58. U Krugel H Kittner P Illes 2001 Mechanisms of adenosine 5′-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo Synapse 39 222-232
59. D Communi N Suarez-Huerta D Dussossoy 2001 Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes J Biol Chem 276 16561-16566
60. RA Nicholas 2001 Identification of the P2Y(12) receptor: A novel member of the P2Y family of receptors activated by extracellular nucleotides Mol Pharmacol 60 416-420
61. SJ Charlton CA Brown GA Weisman 1996 PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors Br J Pharmacol 118 704-710
62. F Dol-Gleizes AM Mares P Savi JM Herbert 1999 Relaxant effect of 2-methyl-thio-adenosine diphosphate on rat thoracic aorta: Effect of clopidogrel Eur J Pharmacol 367 247-253
63. JL Boyer IE Zohn KA Jacobson TK Harden 1994 Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors Br J Pharmacol 113 614-620
64. E Camaioni JL Boyer A Mohanram 1998 Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors J Med Chem 41 183-190
65. A Baurand C Gachet 2003 The P2Y(1) receptor as a target for new antithrombotic drugs: A review of the P2Y(1) antagonist MRS-2179 Cardiovasc Drug Rev 21 67-76
66. MB Kulick KI von 2002 P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes J Pharmacol Exp Ther 303 520-526
67. F Storey 2001 The P2Y12 receptor as a therapeutic target in cardiovascular disease Platelets 12 197-209
68. T Schraft H Franke H Kittner 2003 Functional antagonism of P2Y1 and P2Y12 receptor stimulation in the release of dopamine in the nucleus accumbens Naunyn-Schmiedeberg's Arch Pharmacol 367 123
69. LE Chavez-Noriega CF Stevens 1994 Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices J Neurosci 14 310-317
70. LE Trudeau DG Emery PG Haydon 1996 Direct modulation of the secretory machinery underlies PKA-dependent synaptic facilitation in hippocampal neurons Neuron 17 789-797
71. M Kaneko T Takahashi 2004 Presynaptic mechanism underlying cAMP-dependent synaptic potentiation J Neurosci 24 5202-5208
72. H Franke H Kittner J Grosche P Illes 2003 Enhanced P2Y1 receptor expression in the brain after sensitisation with d -amphetamine Psychopharmacology (Berl) 167 187-194
73. U Krugel B Seidel O Spies 2003 Chronic food restriction alters purinergic receptor mRNA expression in the nucleus accumbens of the rat Drug Dev Res 59 1 95-103
74. H Franke U Krugel J Grosche 2004 P2Y receptor expression on astrocytes in the nucleus accumbens of rats Neuroscience 127 431-441
75. J Korf L Grasdijk BH Westerink 1976 Effects of electrical stimulation of the nigrostriatal pathway of the rat on dopamine metabolism J Neurochem 26 3 579-584
76. LB Geffen TM Jessell AC Cuello LL Iversen 1976 Release of dopamine from dendrites in rat substantia nigra Nature 260 258-260
77. A Mansour JH Meador-Woodruff JR Bunzow 1990 Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: An in situ hybridization-receptor autoradiographic analysis J Neurosci 10 2587-2600
78. E Koga T Momiyama 2000 Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones J Physiol (Lond) 523 Pt 1 163-173
79. G Burnstock 2004 Cotransmission Curr Opin Pharmacol 4 47-52
80. G Burnstock 1995 Noradrenaline and ATP: Cotransmitters and neuromodulators J Physiol Pharmacol 46 365-384
81. DP Westfall KO Sedaa K Shinozuka 1990 ATP as a cotransmitter Ann NY Acad Sci 603 300-310
82. DP Westfall LD Todorov ST Mihaylova-Todorova 2002 ATP as a cotransmitter in sympathetic nerves and its inactivation by releasable enzymes J Pharmacol Exp Ther 303 439-444
83. C Kennedy 1996 ATP as a cotransmitter in perivascular sympathetic nerves J Auton Pharmacol 16 337-340
84. H Kittner U Krugel E Hoffmann P Illes 2000 Effects of intra-accumbens injection of 2-methylthio ATP: A combined open field and electroencephalographic study in rats Psychopharmacology (Berl) 150 123-131
85. U Krugel H Kittner H Franke P Illes 2003 Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo Synapse 47 2 134-142
86. G Bauer 1987 EEG, Drug Effects, and Central Nervous Poisoning. In: E Niedermeyer FH Lopes da Silva (eds.) Electroencephalography Urban & Schwarzenberg Baltimore 567-578
87. W Kropf K Kuschinsky J Krieglstein 1991 Conditioning of apomorphine effects: Simultaneous analysis of the alterations in cortical electroencephalogram and behaviour Naunyn-Schmiedeberg's Arch Pharmacol 343 6 559-567
88. B Ferger W Kropf K Kuschinsky 1994 Studies on electroencephalogram (EEG) in rats suggest that moderate doses of cocaine or d -amphetamine activate D1 rather than D2 receptors Psychopharmacology (Berl) 114 2 297-308
89. W Machleidt L Gutjahr H Hinrichs 1994 Die spektralmuster der grundgefühle: Hunger, angst, aggression, trauer und freude EEG-EMG 25 81-97
90. M Ballarin J Reiriz S Ambrosio N Mahy 1995 Effect of locally infused 2-chloroadenosine, an A1 receptor agonist, on spontaneous and evoked dopamine release in rat neostriatum Neurosci Lett 185 29-32
91. M Okada K Mizuno S Kaneko 1996 Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum Neurosci Lett 212 53-56
92. E Entholzer L Mielke R Pichelmeier 1995 EEG changes during sedation with gamma-butyric acid Anaesthesist 44 345-350
93. MD Low 1987 Psychology, physiology, and the EEG E Niedermeyer FH Lopes da Silva (eds.) Electroencephalography Urban & Schwarzenberg Baltimore 541-548
94. C Corsi A Melani L Bianchi 1999 Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo NeuroReport 10 3933-3937
95. P Popoli P Betto R Reggio G Ricciarello 1995 Adenosine A2A recerptor stimulation enhances striatal extracellular glutamate levels in rats Eur J Pharmacol 287 215-217
96. G Segovia A Arco Del F Mora 1999 Effects of aging on the interaction between glutamate, dopamine, and GABA in striatum and nucleus accumbens of the awake rat J Neurochem 73 2063-2072
97. DR Patel AM Young MJ Croucher 2001 Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: A dual-label microdialysis study Neuroscience 102 101-111
98. A Pintor M Galluzzo R Grieco 2004 Adenosine A2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors J Neurochem 89 152-156
99. KA Kirkpatrick G Burnstock 1992 Evidence that the inhibition of ATP release from sympathetic nerves by adenosine is a physiological mechanism Gen Pharmacol 23 1045-1050
100. JC Horvitz 2002 Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum Behav Brain Res 137 65-74
101. U Krugel T Schraft R Regenthal 2004 Purinergic modulation of extracellular glutamate levels in the nucleus accumbens in vivo Int J Dev Neurosci 22 565-570
102. U Krugel T Schraft R Regenthal 2004 P2Y1 and P2Y12 receptors are involved in the release of glutamate in the nucleus accumbens of the rat in vivo Int J Dev Neurosci 22 586
103. M Herrera-Marschitz ZB You M Goiny 1996 On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis J Neurochem 66 1726-1735
104. W Timmerman BH Westerink 1997 Brain microdialysis of GABA and glutamate: What does it signify? Synapse 27 242-261
105. CM Anderson RA Swanson 2000 Astrocyte glutamate transport: Review of properties, regulation, and physiological functions Glia 32 1-14
106. A Jeremic K Jeftinija J Stevanovic 2001 ATP stimulates calcium-dependent glutamate release from cultured astrocytes J Neurochem 77 664-675
107. RA Wise MA Bozarth 1987 A psychomotor stimulant theory of addiction Psychol Rev 94 469-492
108. GJ Mogenson DL Jones CY Yim 1980 From motivation to action: Functional interface between the limbic system and the motor system Prog Neurobiol 14 69-97
109. LW Swanson 1982 The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat Brain Res Bull 9 321-353
110. P O'Donnell AA Grace 1995 Synaptic interactions among excitatory afferents to nucleus accumbens neurons: Hippocampal gating of prefrontal cortical input J Neurosci 15 3622-3639
111. SR Sesack AY Deutch RH Roth BS Bunney 1989 Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin J Comp Neurol 290 213-242
112. TA Fuller FT Russchen JL Price 1987 Sources of presumptive glutamergic/ aspartergic afferents to the rat ventral striatopallidal region J Comp Neurol 258 317-338
113. TG Robinson PM Beart 1988 Excitant amino acid projections from rat amygdala and thalamus to nucleus accumbens Brain Res Bull 20 467-471
114. A Svensson ML Carlsson A Carlsson 1994 Glutamatergic neurons projecting to the nucleus accumbens can affect motor functions in opposite directions depending on the dopaminergic tone Prog Neuropsychopharmacol Biol Psychiatry 18 1203-1218
115. H Kittner E Hoffmann U Krugel P Illes 2004 P2 receptor-mediated effects on the open field behaviour of rats in comparison with behavioural responses induced by the stimulation of dopamine D2-like and by the blockade of ionotrophic glutamate receptors Behav Brain Res 149 197-208
116. N Dale D Gilday 1996 Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos Nature 383 6597 259-263
117. AJ Pijnenburg Jv Rossum 1973 Letter: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens J Pharm Pharmacol 25 1003-1005
118. SM Brudzynski GJ Mogenson 1985 Association of the mesencephalic locomotor region with locomotor activity induced by injections of amphetamine into the nucleus accumbens Brain Res 334 77-84
119. MG Feenstra MH Botterblom JF Uum van 1995 Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: Inhibition by diazepam Neurosci Lett 189 81-84
120. WJ Schmidt BD Kretschmer 1997 Behavioural pharmacology of glutamate receptors in the basal ganglia Neurosci Biobehav Rev 21 381-392
121. K Nakazawa K Inoue K Ito 1995 Inhibition by suramin and reactive blue 2 of GABA and glutamate receptor channels in rat hippocampal neurons Naunyn-Schmiedeberg's Arch Pharmacol 351 202-208
122. JD Salamone M Correa S Mingote SM Weber 2003 Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: Implications for studies of natural motivation, psychiatry, and drug abuse J Pharmacol Exp Ther 305 1-8
123. DL Jones GJ Mogenson 1980 Nucleus accumbens to globus pallidus GABA projection subserving ambulatory activity Am J Physiol 238 R65-R69
124. K Wirkner L Koles S Thummler 2002 Interaction between P2Y and NMDA receptors in layer V pyramidal neurons of the rat prefrontal cortex Neuropharmacology 42 476-488
125. H Kittner H Franke W Fischer 2003 Stimulation of P2Y1 receptors causes anxiolytic-like effects in the rat elevated plus-maze: Implications for the involvement of P2Y1 receptor-mediated nitric oxide production Neuropsychopharmacology 28 435-444
126. H Kittner U Krügel P Illes 2001 The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2′,4′-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural senstization caused by repeated amphetamine injections in rats Neuroscience 102 241-243
127. J Pintor A Porras F Mora MT Miras-Portugal 1993 Amphetamine-induced release of diadenosine polyphosphates-Ap4A and Ap5A-from caudate putamen of conscious rat Neurosci Lett 150 13-16
128. K Ishiwari SM Weber S Mingote 2004 Accumbens dopamine and the regulation of effort in food-seeking behavior: Modulation of work output by different ratio or force requirements Behav Brain Res 151 83-91
129. L Hernandez BG Hoebel 1988 Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis Life Sci 42 1705-1712
130. L Hernandez BG Hoebel 1988 Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens Physiol Behav 44 599-606
131. H Kittner U Krugel E Hoffmann P Illes 2004 Modulation of feeding behaviour by blocking purinergic receptors in the rat nucleus accumbens: A combined microdialysis, electroencephalogrphic and behavioural study Eur J Neurosci 19 396-404
132. M Yoshida H Yokoo K Mizoguchi 1992 Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: Measurement by in vivo microdialysis Neurosci Lett 139 73-76
133. H Kittner U Krugel IM Ashmawy El P Illes 2000 Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors Eur J Pharmacol 406 R13-R14
134. PW Kalivas 1993 Neurotransmitter regulation of dopamine neurons in the ventral tegmental area Brain Res Brain Res Rev 18 75-113
135. U Krugel H Kittner H Franke P Illes 2003 Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo Synapse 47 134-142
136. O Spies U Krugel H Kittner P Illes 2002 A(2A) adenosine receptor but not A(1) receptor stimulation reduces food intake in rats Naunyn-Schmiedeberg's Arch Pharmacol 365 117
137. H Kittner U Krugel E Hoffmann P Illes 2001 Stimulation of P2Y receptors enhances feeding behaviour in rats Naunyn-Schmiedeberg's Arch Pharmacol 363 R33118
138. CS Maldonado-Irizarry CJ Swanson AE Kelley 1995 Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus J Neurosci 15 6779-6788
139. TR Stratford AE Kelley 1999 Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior J Neurosci 19 11040-11048
140. EN Pothos I Creese BG Hoebel 1995 Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake J Neurosci 15 6640-6650
141. EN Pothos 2001 The effects of extreme nutritional conditions on the neurochemistry of reward and addiction Acta Astronaut 49 391-397
142. BG Hoebel 1997 Neuroscience and appetitive behavior research: 25 years Appetite 29 119-133