Cationic lipid-protamine-DNA (LPD) complexes for delivery of antisense c-myc oligonucleotides

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 60, Issue 2, 2005, Pages 287-294

  Junghans, Monika ^a   Loitsch, Stefan M ^a   Steiniger, Sebastian C J ^a   Kreuter, Jörg ^a   Zimmer, Andreas ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antisense oligonucleotides; Liposomes; Nanoparticles; Protamine

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DEOXYRIBONUCLEASE I; DRUG CARRIER; LIPOSOME; MESSENGER RNA; MYC PROTEIN; NANOPARTICLE; NUCLEASE; OLIGONUCLEOTIDE; PROTAMINE;

ADSORPTION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG TARGETING; HUMAN; HUMAN CELL; HYDRODYNAMICS; INCUBATION TIME; MOLECULAR STABILITY; PARTICLE SIZE; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION;

CULTURE MEDIA; DNA; DRUG DELIVERY SYSTEMS; HUMANS; LIPIDS; OLIGONUCLEOTIDES, ANTISENSE; PROTAMINES; PROTO-ONCOGENE PROTEINS C-MYC; RIBONUCLEASE H, CALF THYMUS; RNA, MESSENGER; U937 CELLS;

EID: 20444402691     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.01.006     Document Type: Article

References (27)

1. S.T. Crooke Molecular mechanisms of antisense drugs: human RNase H Antisense Nucleic Acid Drug Dev. 9 1999 377 379
2. R. Giles, D. Spiller, R. Clark, and D. Tidd Antisense morpholino oligonucleotide analog induces missplicing of c-myc mRNA Antisense Nucleic Acid Drug Dev. 9 1999 213 220
3. B.F. Baker, and B.P. Monia Novel mechanisms for antisense-mediated regulation of gene expression Biochim. Biophys. Acta 1489 1999 3 18
4. S.T. Crooke Molecular mechanisms of action of antisense drugs Biochim. Biophys. Acta 1489 1999 31 44
5. D. Stein, E. Foster, S.-B. Huang, D. Weller, and J. Summerton A specificity comparison of four antisense types: morpholino, 2′-O-methyl RNA, DNA, and phosphorothioate DNA Antisense Nucleic Acid Drug Dev. 7 1997 151 157
6. P.J. Bates, J.B. Kahlon, S.D. Thomas, J.O. Trent, and D.M. Miller Antiproliferative activity of G-rich oligonucleotides correlates with protein binding J. Biol. Chem. 274 1999 26369 26377
7. S. Basu, and E. Wickstrom Temperature and salt dependence of higher order structure formation by antisense c-myc and c-myb phosphorothioate oligodeoxyribonucleotides containing tetraguanylate tracts Nucleic Acids Res. 25 1997 1327 1332
8. M. Junghans, J. Kreuter, and A. Zimmer Antisense delivery using protamine-oligonucleotide particles Nucleic Acids Res. 28 2000 e45
9. D. Lochmann, V. Vogel, J. Weyermann, N. Dinauer, H. von Briesen, J. Kreuter, D. Schubert, and A. Zimmer Physicochemical characterisation of protamine-phosphorothioate nanoparticles J. Microencapsul. 21 6 2004 625 641
10. D. Lochmann, J. Weyermann, C. Georgens, R. Prassl, and A. Zimmer Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system: Part 1, physicochemical characterisation Eur. J. Pharm. Biopharm. 59 2005 419 429
11. M. Gonzalez Ferreiro, R.M. Crooke, L. Tillman, G. Hardee, and R. Bodmeier Stability of polycationic complexes of an antisense oligonucleotide in rat small intestine homogenates Eur. J. Pharm. Biopharm. 55 2003 19 26
12. N. Dinauer, D. Lochmann, I. Demirhan, A. Bouazzaoui, A. Zimmer, A. Chandra, J. Kreuter, and H. von Briesen Intracellular tracking of protamine/antisense oligonucleotide nanoparticles and their inhibitory effect on HIV-1 transactivation J. Control Release 96 2004 497 507
13. A. Zimmer, S. Atmaca-Abdel Aziz, M. Gilbert, D. Werner, and C.R. Noe Synthesis of cholesterol modified cationic lipids for liposomal drug delivery of antisense oligonucleotides Eur. J. Pharm. Biopharm. 47 1999 175 178
14. S.M. Loitsch, S. Kippenberger, N. Dauletbaev, T.O.F. Wagner, and J. Bargon Reverse transcription competitive multiplex PCR improves quantification of mRNA in clinical samples - application to the low abundance CFTR mRNA Clin. Chem. 1999 45
15. T. Kanamaru, T. Takagi, Y. Takakura, and M. Hashida Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes J. Drug Target. 5 1998 235 246
16. H.-P. Zobel, D. Werner, M. Gilbert, C.R. Noe, F. Stieneker, J. Kreuter, and A. Zimmer Effect of ultrasonication on the stability of oligonucleotides adsorbed on nanoparticles and liposomes J. Microencapsul. 16 1999 501 509
17. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
18. H. Towbin, T. Staehelin, and J. Gordon Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc. Natl Acad. Sci. USA 76 1979 4350 4353
19. S.M. Loitsch, C. von Mallinckrodt, S. Kippenberger, D. Steinhilber, T.O. Wagner, and J. Bargon Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells Biochem. Biophys. Res. Commun. 276 2000 571 578
20. X. Gao, and L. Huang Potentiation of cationic liposome-mediated gene delivery by polycations Biochemistry 35 1996 1027 1036
21. P.L. Felgner, T.R. Gadek, M. Holm, R. Roman, H.W. Chan, M. Wenz, J.P. Northrop, G.M. Ringold, and M. Danielsen Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl Acad. Sci. USA 84 1987 7413 7417
22. J.C. Birchall, I.W. Kellaway, and M. Gumbleton Physical stability and in vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes Int. J. Pharm. 197 2000 221 231
23. D. Fischer, T. Bieber, Y. Li, H.P. Elsässer, and T. Kissel A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity Pharm. Res. 16 1999 1273 1279
24. M. Junghans, J. Kreuter, and A. Zimmer Phosphodiester and phosphorothioate oligonucleotide condensation and preparation of antisense nanoparticles Biochim. Biophys. Acta 1544 2001 177 188
25. F.L. Sorgi, S. Bhattacharya, and L. Huang Protamine sulfate enhances lipid-mediated gene transfer Gene Ther. 4 1997 961 968
26. C. Welz, W. Neuhuber, H. Schreier, R. Repp, W. Rascher, and A. Fahr Nuclear gene targeting using negatively charged liposomes Int. J. Pharm. 196 2000 251 252
27. A. Rosolen, E. Kyle, C. Chavany, R. Bergan, E.T. Kalman, R. Crouch, and L. Neckers Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937 Biochimie 75 1993 79 87