Physicochemical characterization of protamine-phosphorothioate nanoparticles

Journal of Microencapsulation

Volumn 21, Issue 6, 2004, Pages 625-641

  Lochmann, D ^a   Vogel, V ^a   Weyermann, J ^a   Dinauer, N ^b   Von Briesen, H ^b   Kreuter, J ^a   Schubert, D ^a   Zimmer, Andreas ^c  

^a GOETHE UNIVERSITY   (Germany)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antisense; Nanoparticles; Oligonucleotides; Phosphorothioate; Protamine

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DRUG CARRIER; MACROGOL; NANOPARTICLE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PROTAMINE; SODIUM CHLORIDE; WATER;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; COLLOID; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENCAPSULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRODYNAMICS; LIGHT SCATTERING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PARTICLE SIZE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SEDIMENTATION RATE; SURFACE CHARGE; ULTRACENTRIFUGE; ZETA POTENTIAL;

CHEMISTRY, PHYSICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; LIGHT; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; NANOSTRUCTURES; OLIGONUCLEOTIDES, ANTISENSE; PARTICLE SIZE; PHOSPHATES; PROTAMINES; SCATTERING, RADIATION; SURFACE PROPERTIES; ULTRACENTRIFUGATION;

EID: 9644312752     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652040400000504     Document Type: Article

References (34)

1. Ando,T., Yamasaki, M., and Suziki, K., 1973, Protamines: Isolation, characterisation, structure and function (Berlin, Heidelberg, New York: Springer Verlag).
2. Askari, F. K., and McDonnell, W. M., 1996, Antisense-oligonucleotide therapy. New England Journal of Medicine, 334, 316-318.
3. Ausserer, W. A., and Biros, M. L., 1995, High-resolution analysis and purification of synthetic oligonucleotides with strong anion-exchange HPLC. Biotechniques, 19, 136-139.
4. Bergot, B. J., and Zon, G., 1992, Separation of synthetic phosphorothioate oligonucleotides from phosphodiester-defect species by strong-anion exchange HPLC. Annals of the New York Academy of Science 660, 310-312.
5. Berne, B. J., and Pecora, R., 2000, Dynamic Light Scattering - With Applications to Chemistry, Biology, and Physics (Mineola, New York: Dover Publications).
6. Couvreur, P., and Malvy, C., 2000, Pharmaceutical Aspects of Oligonuceotides (London: Taylor & Francis).
7. De Bree, F., 2001. Genomic-based drugs in R&D - the promise of a new era. Genomic-based Drug Data Report and Regenerative Therapy 1, 17-29.
8. De Smedt, S. C., Demeester, J., and Hennink, W. E., 2000, Cationic polymer based gene delivery systems. Pharmceutical Research 17, 113-126.
9. Eisenberg, H., 1976, Biological Macromolecules and Polyelectrolytes in Solution (Oxford: Clarendon Press).
10. Fattal, E., Vauthier, C., Aynie, I., Nakada, Y., Lambert, G., Malvy, C., and Couvreur, P., 1998, Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides. Journal of Controlled Release, 53, 137-143.
11. Fujita, H., 1975, Ultracentrifugation in biochemistry (New York: John Wiley & Sons).
12. Gewirtz, A. M., Sokol, D. L., and Ratajczak, M. Z., 1998, Nucleic acid therapeutics: state of the art and future prospects. Blood, 92, 712-736.
13. Gonzalez Ferreiro, M., Crooke, R. M., Tillman, L., Hardee, G., and Bodmeier, R., 2003, Stability of polycationic complexes of an antisense oligonucleotide in rat small intestine homogenates. European Journal of Pharmaceutics and Biopharmaceutics, 55, 19-26.
14. Gonzalez Ferreiro, M., Tillman, L., Hardee, G., and Bodmeier, R., 2001, Characterization of complexes of an antisense oligonucleotide with protamine and poly-L-lysine salts. Journal of Controlled Release 73, 381-390.
15. Junghans, M., Kreuter, J., and Zimmer, A., 2000, Antisense delivery using protamineoligonucleotide particles. Nucleic Acids Research, 28, e45.
16. Junghans, M., Kreuter, J., and Zimmer, A., 2001, Phosphodiester and phosphorothioate oligonucleotide condensation and preparation of antisense nanoparticles. Biochimica et Biophysica Acta 1544, 177-188.
17. Langer, K., Balthasar, S., Vogel, V., Dinauer, N., Von Briesen, H., and Schubert, D., 2003, Optimization of the preparation process for human serum albumin (HSA) nanoparticles. International Journal of Pharmaceutics, 257, 169-180.
18. Lebedeva, I., and Stein, C. A., 2001, Antisense oligonucleotides: promise and reality. Annual Review of Pharmacology and Toxicology, 41, 403-419.
19. Lebedeva, I., Benimetskaya, L., Stein, C. A., and Vilenchik, M., 2000, Cellular delivery of antisense oligonucleotides. European Journal of Pharmaceutics and Biopharmaceutics, 50, 101-119.
20. Martin, A., Swarbrick, J., and Cammarata, A., 1983, Physical Pharmacy - Physical Chemical Principles in the Pharmaceutical Sciences (Philadelphia: Lea and Febriger).
21. Metelev, V., and Agrawal, S., 1992, Ion-exchange high-performance liquid chromatography analysis of oligodeoxyribonucleotide phosphorothioates. Analytical Biochemistry 200, 342-346.
22. Pecora, R., 2000, Dynamic light scattering measurement of nanometer particles in liquids. Journal of Nanoparticle Research, 2, 123-131.
23. Prabha, S., Zhou, W. Z., Panyam, J., and Labhasetwar, V., 2002, Size-dependency of nanoparticlemediated gene transfection: studies with fractionated nanoparticles. International Journal of Pharmaceutics, 244, 105-115.
24. Schachman, H. K., 1959, Ultracentrifugation in Biochemistry (New York: Academic Press).
25. Schlingensiepen, R., Brysch, W., and Schlingensiepen, K. H., 1997, Antisense - From Technology to Therapy. (Berlin: Blackwell Wissenschaft).
26. Schuck, P., 2000, Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophysical Journal, 78, 1606-1619.
27. Schuck, P., and Rossmanith, P., 2000, Determination of the sedimentation coefficient distribution by least-squares boundary modeling. Biopolymers, 54, 328-341.
28. Schuck, P., Perugini, M. A., Gonzales, N. R., Howlett, G. J., and Schubert, D., 2002, Size distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems. Biophysical Journal, 82, 1096-1111.
29. Tamm, I., Dorken, B., and Hartmann, G., 2001, Antisense therapy in oncology: new hope for an old idea? Lancet, 358, 489-497.
30. Vogel, V., Gohy, J. F., Lohmeijer, B. G. G., Van Den Broek, J. A., Haase, W., Schubert, U. S., and Schubert, D., 2003, Metallo-supramolecular micelles: studies by analytical ultracentrifugation and electron microscopy. Journal of Polymer Science A, 41, 3159-3168.
31. Vogel, V., Langer, K., Balthasar, S., Schuck, P., Mächtle, W., Haase, W., Tziatzios, C., and Schubert, D., 2002, Characterisation of serum albumin nanoparticles by sedimentation velocity analysis and electron microscopy. Progress in Colloid and Polymer Science, 119, 31-36.
32. Wehling, K., Krauss, S., and Wagner, K. G., 1976, Cooperative binding of fluorescein-labeled clupeine by DNA. Nucleic Acids Research 3, 149-164.
33. Zamecnik, P. C., and Stephenson, M. L., 1978, Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proceedings of the National Academy of Sciences (USA), 75, 280-284.
34. Zobel, H. P., Kreuter, J., Werner, D., Noe, C. R., Kumel, G., and Zimmer, A., 1997, Cationic polyhexylcyanoacrylate nanoparticles as carriers for antisense oligonucleotides. Antisense Nucleic Acid Drug Development, 7, 483-493.