Cell apoptosis induced by a synthetic carbazole compound LCY-2-CHO is mediated through activation of caspase and mitochondrial pathways

Biochemical Pharmacology

Volumn 70, Issue 1, 2005, Pages 102-112

  Hsu, Ming Jen ^a   Chao, Yee ^b   Chang, Ying Hsin ^a   Ho, Feng Ming ^c   Huang, Li Jiau ^d   Huang, Ya Ling ^d   Luh, Tien Yau ^e   Chen, Chih Ping ^c   Lin, Wan Wan ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c TAO YUAN GENERAL HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Carbazole; Caspases; LCY 2 CHO; Mitochondria

Indexed keywords

9 (2 CHLOROBENZYL) 9H CARBAZOLE 3 CARBALDEHYDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLGLUTAMYLISOLEUCYLASPARTYL FLUOROMETHYL KETONE; CARBAZOLE DERIVATIVE; CASPASE 3; CASPASE 6 INHIBITOR; CASPASE 8 INHIBITOR; CASPASE INHIBITOR; CYTOCHROME C; ENZYME INHIBITOR; LACTATE DEHYDROGENASE; PROPIDIUM IODIDE; PROTEIN BID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL CYCLE G1 PHASE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; LEUKEMIA CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CARBAZOLES; CASPASES; CATHEPSINS; CELL LINE, TUMOR; CYTOCHROMES C; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 20444393146     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.04.014     Document Type: Article

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