Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper

Immunopharmacology

Volumn 35, Issue 3, 1997, Pages 195-202

  Sawada, Tetsuji ^a   Hashimoto, Shiori ^b   Furukawa, Hiroshi ^a   Tohma, Shigeto ^a   Inoue, Tetsufumi ^a   Ito, Koji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

apoptosis; bucillamine; reactive oxygen species

Indexed keywords

ANTIRHEUMATIC AGENT; BUCILLAMINE; CATALASE; COPPER; CYSTEINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DEGRADATION; DRUG MECHANISM; ERYTHROCYTE; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MONOCYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ARTHRITIS, RHEUMATOID; CELL LINE; COPPER; CYSTEINE; DRUG SYNERGISM; HUMANS; MONOCYTES; REACTIVE OXYGEN SPECIES;

EID: 0031055013     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(96)00145-2     Document Type: Article

References (15)

1. Buttke, T.M. and Sandstrom, P.A., 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today, 15: 7-10, review, 59 references.
2. Firestein, G.S., Yeo, M. and Zvaifler, N.J., 1995. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest., 96: 1631-1638.
3. Hashimoto, K. and Lipsky, P.E., 1993. Immunosuppression by the disease modifying antirheumatic drug bucillamine: Inhibition of human T lymphocyte function by bucillamine and its metabolites. J. Rheumatol., 20: 953-957.
4. Herrmann, M., Lorenz, H.M., Voll, R., Grünke, M. and Kalden, J.R., 1994. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res., 22: 5506-5507.
5. Hirohata, S. and Lipsky, P.E., 1993. Regulation of B cell function by bucillamine, a novel disease-modifying antirheumatic drug. Clin. Immunol. Immunopathol., 66: 43-51.
6. Hirohata, S. and Lipsky, P.E., 1994. Comparative inhibitory effects of bucillamine and D-penicillamine on the function of human B cells and T cells. Arthritis Rheum., 37: 942-950.
7. Lennon, S.V., Martin, S.J. and Cotter, T.G., 1991. Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif., 24: 203-214.
8. Martin, S.J., Reutelingsperger, C.P.M., McGahon, A.J., Rader, J.A., van Schie, R.C.A.A., LaFace, D.M. and Green, D.R., 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition of Bcl-2 and Abl. J. Exp. Med., 182: 1545-1556.
9. Nakajima, T., Aono, H., Hasunuma, T., Yamamoto, K., Shirai, T., Hirohata, K. and Nishioka, K., 1995. Apoptosis and functional FAS antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum., 38: 485-491.
10. Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. and Riccardi, C., 1991. A rapid method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139: 271-279.
11. Robinson, J.P., Carter, W.O. and Narayanan, P.K., 1994. Oxidative product formation analysis by flow cytometry. In: Z. Darzynkiewicz, J.P. Robinson and H.A. Crissman (Eds.), Methods in Cell Biology, Vol. 41, Flow Cytometry, 2nd Ed. Academic Press, San Diego, pp. 437-467.
12. Strom, H. and Ahnfelt-Ronne, I., 1989. Second-line anti-rheumatic drugs and free radical scavenging. Agents Actions, 26: 235-237.
13. Tsuchiya, S., Yamabe, Y., Yamaguchi, Y., Kobayashi, Y., Konno, T. and Tada, K., 1980. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int. J. Cancer, 26: 171-176.
14. Verhoven, B., Schlegel, R.A. and Williamson, P., 1995. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med., 182: 1597-1601.
15. Yamanaka, H., Hakoda, M., Kamatani, M., Kashiwazaki, S. and Carson, D.A., 1993. Formation of DNA strand breaks by D-penicillamine and bucillamine in human lymphocytes. Immunopharmacology, 26: 113-118.