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Volumn 1, Issue 1, 2004, Pages 43-49

Delineation of ligand binding and receptor signaling activities of purified P2Y receptors reconstituted with heterotrimeric G proteins

Author keywords

G protein coupled receptor; Nucleotide(s); P2Y receptor; Platelets; Receptor purification; RGS proteins

Indexed keywords

DIGITONIN; EPITOPE; GUANOSINE TRIPHOSPHATASE; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINE P2Y12 RECEPTOR; PURINE P2Y2 RECEPTOR; RGS PROTEIN;

EID: 20444371947     PISSN: 15739538     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11302-004-4748-1     Document Type: Review
Times cited : (8)

References (38)
  • 1
    • 0027661421 scopus 로고
    • 2-purinergic receptors for extracellular ATP and other nucleotides
    • 2- purinergic receptors for extracellular ATP and other nucleotides Am J Physiol 265 C577-C606
    • (1993) Am. J. Physiol. , vol.265
    • Dubyak, G.R.1    El-Moatassim, C.2
  • 3
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • V Ralevic G Burnstock 1998 Receptors for purines and pyrimidines Pharmacol Rev 50 3 413-492
    • (1998) Pharmacol. Rev. , vol.50 , Issue.3 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 4
    • 0018804588 scopus 로고
    • ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase
    • DMF Cooper M Rodbell 1979 ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase Nature 282 517-518
    • (1979) Nature , vol.282 , pp. 517-518
    • Cooper, D.M.F.1    Rodbell, M.2
  • 5
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • G Hollopeter HM Jantzen D Vincent 2001 Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 202-207
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 6
    • 0034858808 scopus 로고    scopus 로고
    • Molecular cloning of the platelet P2T(AC) ADP receptor: Pharmacological comparison with another ADP receptor, the P2Y(1) receptor
    • J Takasaki M Kamohara T Saito 2001 Molecular cloning of the platelet P2T(AC) ADP receptor: Pharmacological comparison with another ADP receptor, the P2Y(1) receptor Mol Pharmacol 60 3 432-439
    • (2001) Mol. Pharmacol. , vol.60 , Issue.3 , pp. 432-439
    • Takasaki, J.1    Kamohara, M.2    Saito, T.3
  • 7
    • 0035896562 scopus 로고    scopus 로고
    • ADP is the cognate ligand for the orphan G-protein coupled receptor SP1999
    • FL Zhang L Luo E Gustafson 2001 ADP is the cognate ligand for the orphan G-protein coupled receptor SP1999 J Biol Chem 276 11 8608-8615
    • (2001) J. Biol. Chem. , vol.276 , Issue.11 , pp. 8608-8615
    • Zhang, F.L.1    Luo, L.2    Gustafson, E.3
  • 8
    • 0035798576 scopus 로고    scopus 로고
    • Identification of a novel human ADP receptor coupled to G(i)
    • D Communi NS Gonzalez M Detheux 2001 Identification of a novel human ADP receptor coupled to G(i) J Biol Chem 276 44 41479-41485
    • (2001) J. Biol. Chem. , vol.276 , Issue.44 , pp. 41479-41485
    • Communi, D.1    Gonzalez, N.S.2    Detheux, M.3
  • 9
    • 0034646649 scopus 로고    scopus 로고
    • A G protein-coupled receptor for UDP-glucose
    • JK Chambers LE Macdonald HM Sarau 2000 A G protein-coupled receptor for UDP-glucose J Biol Chem 275 15 10767-10771
    • (2000) J. Biol. Chem. , vol.275 , Issue.15 , pp. 10767-10771
    • Chambers, J.K.1    Macdonald, L.E.2    Sarau, H.M.3
  • 11
    • 0022356539 scopus 로고
    • Functional activation of beta-adrenergic receptors by thiols in the presence or absence of agonists
    • SE Pedersen EM Ross 1985 Functional activation of beta-adrenergic receptors by thiols in the presence or absence of agonists J Biol Chem 260 26 14150-14157
    • (1985) J. Biol. Chem. , vol.260 , Issue.26 , pp. 14150-14157
    • Pedersen, S.E.1    Ross, E.M.2
  • 12
    • 0031466317 scopus 로고    scopus 로고
    • Molecular cloning and expression of an avian G protein-coupled P2Y receptor
    • JL Boyer GL Waldo TK Harden 1997 Molecular cloning and expression of an avian G protein-coupled P2Y receptor Mol Pharmacol 52 6 928-934
    • (1997) Mol. Pharmacol. , vol.52 , Issue.6 , pp. 928-934
    • Boyer, J.L.1    Waldo, G.L.2    Harden, T.K.3
  • 13
    • 0034074488 scopus 로고    scopus 로고
    • A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is non-selectively activated by all nucleoside triphosphates
    • JL Boyer SM Delaney D Villanveva TK Harden 2000 A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is non-selectively activated by all nucleoside triphosphates Mol Pharmacol 57 805-810
    • (2000) Mol. Pharmacol. , vol.57 , pp. 805-810
    • Boyer, J.L.1    Delaney, S.M.2    Villanveva, D.3    Harden, T.K.4
  • 14
    • 4344619319 scopus 로고    scopus 로고
    • Nucleotide release provides a mechanism for airway surface liquid homeostasis
    • ER Lazarowski R Tarran BR Grubb 2004 Nucleotide release provides a mechanism for airway surface liquid homeostasis J Biol Chem 279 35 36855-36864
    • (2004) J. Biol. Chem. , vol.279 , Issue.35 , pp. 36855-36864
    • Lazarowski, E.R.1    Tarran, R.2    Grubb, B.R.3
  • 15
    • 0036720462 scopus 로고    scopus 로고
    • Pharmacology of INS37217 [P(1)-(uridine 5′)-P(4)-(2′-deoxycytidine 5′)tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis
    • BR Yerxa JR Sabater CW Davis 2002 Pharmacology of INS37217 [P(1)-(uridine 5′)-P(4)-(2′-deoxycytidine 5′)tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis J Pharmacol Exp Ther 302 3 871-880
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , Issue.3 , pp. 871-880
    • Yerxa, B.R.1    Sabater, J.R.2    Davis, C.W.3
  • 16
    • 0031914973 scopus 로고    scopus 로고
    • Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
    • JL Daniel C Dangelmaier J Jin 1998 Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets J Biol Chem 273 4 2024-2029
    • (1998) J. Biol. Chem. , vol.273 , Issue.4 , pp. 2024-2029
    • Daniel, J.L.1    Dangelmaier, C.2    Jin, J.3
  • 17
    • 0031593698 scopus 로고    scopus 로고
    • The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
    • B Hechler A Eckly P Ohlmann 1998 The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel Br J Haematol 103 3 858-866
    • (1998) Br. J. Haematol. , vol.103 , Issue.3 , pp. 858-866
    • Hechler, B.1    Eckly, A.2    Ohlmann, P.3
  • 18
    • 0032105512 scopus 로고    scopus 로고
    • The P2Y1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation
    • B Hechler C Leon C Vial 1998 The P2Y1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation Blood 92 1 152-159
    • (1998) Blood , vol.92 , Issue.1 , pp. 152-159
    • Hechler, B.1    Leon, C.2    Vial, C.3
  • 19
    • 0042703242 scopus 로고    scopus 로고
    • Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis
    • PB Conley SM Delaney 2003 Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis Curr Opin Hematol 10 5 333-338
    • (2003) Curr. Opin. Hematol. , vol.10 , Issue.5 , pp. 333-338
    • Conley, P.B.1    Delaney, S.M.2
  • 21
    • 1642498136 scopus 로고    scopus 로고
    • Agonist binding- and Gq-stimulating activities of the purified human P2Y1 receptor
    • GL Waldo TK Harden 2004 Agonist binding- and Gq-stimulating activities of the purified human P2Y1 receptor Mol Pharmacol 65 426-436
    • (2004) Mol. Pharmacol. , vol.65 , pp. 426-436
    • Waldo, G.L.1    Harden, T.K.2
  • 22
    • 0025303260 scopus 로고
    • Mutational analysis of beta-adrenergic receptor glycosylation
    • E Rands MR Candelore AH Cheung 1990 Mutational analysis of beta-adrenergic receptor glycosylation J Biol Chem 265 18 10759-10764
    • (1990) J. Biol. Chem. , vol.265 , Issue.18 , pp. 10759-10764
    • Rands, E.1    Candelore, M.R.2    Cheung, A.H.3
  • 23
    • 0026066729 scopus 로고
    • Glycosylation of high-affinity thrombin receptors appears necessary for thrombin binding
    • GH Frost JS Bergmann DH Carney 1991 Glycosylation of high-affinity thrombin receptors appears necessary for thrombin binding Biochem Biophys Res Commun 180 1 349-355
    • (1991) Biochem. Biophys. Res. Commun. , vol.180 , Issue.1 , pp. 349-355
    • Frost, G.H.1    Bergmann, J.S.2    Carney, D.H.3
  • 24
    • 0036841643 scopus 로고    scopus 로고
    • Quantitation of the P2Y1 receptor with a high affinity radiolabeled antagonist
    • GL Waldo J Corbitt JL Boyer 2002 Quantitation of the P2Y1 receptor with a high affinity radiolabeled antagonist Mol Pharmacol 62 1249-1257
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1249-1257
    • Waldo, G.L.1    Corbitt, J.2    Boyer, J.L.3
  • 25
    • 0028961594 scopus 로고
    • Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits
    • T Kozasa AG Gilman 1995 Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits J Biol Chem 270 1734-1741
    • (1995) J. Biol. Chem. , vol.270 , pp. 1734-1741
    • Kozasa, T.1    Gilman, A.G.2
  • 26
    • 1642513141 scopus 로고    scopus 로고
    • Expression, purification and reconstitution of recombinant phospholipase C-β isoenzymes
    • A Paterson TK Harden 1996 Expression, purification and reconstitution of recombinant phospholipase C-β isoenzymes Methods Neurosci 29 246-263
    • (1996) Methods Neurosci. , vol.29 , pp. 246-263
    • Paterson, A.1    Harden, T.K.2
  • 27
    • 20444417987 scopus 로고
    • Reconstitutions of Transporters, Receptors, and Pathological States Academic Press Orlando, Florida
    • E Racker 1985 Reconstitutions of Transporters, Receptors, and Pathological States Academic Press Orlando, Florida
    • (1985)
    • Racker, E.1
  • 28
    • 0033578385 scopus 로고    scopus 로고
    • Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins
    • S Mukhopadhyay EM Ross 1999 Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins Proc Natl Acad Sci USA 96 17 9539-9544
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.17 , pp. 9539-9544
    • Mukhopadhyay, S.1    Ross, E.M.2
  • 29
    • 0035800830 scopus 로고    scopus 로고
    • RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity
    • RJ Kimple L Vries De H Tronchere 2001 RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity J Biol Chem 276 31 29275-29281
    • (2001) J. Biol. Chem. , vol.276 , Issue.31 , pp. 29275-29281
    • Kimple, R.J.1    De Vries, L.2    Tronchere, H.3
  • 31
    • 0031594716 scopus 로고    scopus 로고
    • The G protein β5 subunit interacts selectively with the Gq α subunit
    • JE Fletcher MA Lindorfer JM DeFilippo 1998 The G protein β5 subunit interacts selectively with the Gq α subunit J Biol Chem 273 1 636-644
    • (1998) J. Biol. Chem. , vol.273 , Issue.1 , pp. 636-644
    • Fletcher, J.E.1    Lindorfer, M.A.2    DeFilippo, J.M.3
  • 32
    • 0031283166 scopus 로고    scopus 로고
    • Reconstitution of bovine A 1 adenosine receptors and G proteins in phospholipid vesicles: βγ-subunit composition influences guanine nucleotide exchange and agonist binding
    • RA Figler MA Lindorfer SG Graber 1997 Reconstitution of bovine A 1 adenosine receptors and G proteins in phospholipid vesicles: βγ-subunit composition influences guanine nucleotide exchange and agonist binding Biochem 36 51 16288-16299
    • (1997) Biochem. , vol.36 , Issue.51 , pp. 16288-16299
    • Figler, R.A.1    Lindorfer, M.A.2    Graber, S.G.3
  • 33
    • 0036490096 scopus 로고    scopus 로고
    • Regulators of G-protein signalling as new central nervous system drug targets
    • RR Neubig DP Siderovski 2002 Regulators of G-protein signalling as new central nervous system drug targets Nat Rev Drug Discov 1 3 187-197
    • (2002) Nat. Rev. Drug Discov. , vol.1 , Issue.3 , pp. 187-197
    • Neubig, R.R.1    Siderovski, D.P.2
  • 34
    • 0035874503 scopus 로고    scopus 로고
    • A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes
    • Y Nagata M Oda H Nakata 2001 A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes Blood 97 10 3051-3060
    • (2001) Blood , vol.97 , Issue.10 , pp. 3051-3060
    • Nagata, Y.1    Oda, M.2    Nakata, H.3
  • 35
    • 0035477528 scopus 로고    scopus 로고
    • RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes
    • D Yowe N Weich M Prabhudas 2001 RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes Biochem J 359 Pt 1 109-118
    • (2001) Biochem. J. , vol.359 , Issue.PART 1 , pp. 109-118
    • Yowe, D.1    Weich, N.2    Prabhudas, M.3
  • 36
    • 0036223127 scopus 로고    scopus 로고
    • Cloning and characterization of a novel regulator of G protein signalling in human platelets
    • AW Gagnon DL Murray RJ Leadley 2002 Cloning and characterization of a novel regulator of G protein signalling in human platelets Cell Signal 14 7 595-606
    • (2002) Cell Signal , vol.14 , Issue.7 , pp. 595-606
    • Gagnon, A.W.1    Murray, D.L.2    Leadley, R.J.3
  • 38
    • 2442717874 scopus 로고    scopus 로고
    • RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling
    • LS Bernstein S Ramineni C Hague 2004 RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling J Biol Chem 279 20 21248-21256
    • (2004) J. Biol. Chem. , vol.279 , Issue.20 , pp. 21248-21256
    • Bernstein, L.S.1    Ramineni, S.2    Hague, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.