-
1
-
-
0027939946
-
Proopiomelanocortin-derived peptides
-
Bertagna X. Proopiomelanocortin-derived peptides. Endocrinol Metab Clin North Am 1994; 23:467-485.
-
(1994)
Endocrinol Metab Clin North Am
, vol.23
, pp. 467-485
-
-
Bertagna, X.1
-
2
-
-
0032772960
-
The central melanocortin system and energy homeostasis
-
Cone RD. The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 1999; 10:211-216.
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 211-216
-
-
Cone, R.D.1
-
3
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature 2000; 404:661-671.
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr., D.3
-
4
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
Yeo GS, Farooqi IS, Aminian S, et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998; 20:111-112.
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
Farooqi, I.S.2
Aminian, S.3
-
5
-
-
0031662163
-
A frameshift mutation in human MC4R is associated with a dominant form of obesity
-
Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998; 20:113-114.
-
(1998)
Nat Genet
, vol.20
, pp. 113-114
-
-
Vaisse, C.1
Clement, K.2
Guy-Grand, B.3
Froguel, P.4
-
6
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, Keogh JM, Yeo GS, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348:1085-1095.
-
(2003)
N Engl J Med
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.3
-
7
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88:131-141.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
8
-
-
12944331892
-
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors
-
Ste Marie L, Miura GI, Marsh DJ, et al. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc Natl Acad Sci U S A 2000; 97:12339-12344.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12339-12344
-
-
Ste Marie, L.1
Miura, G.I.2
Marsh, D.J.3
-
9
-
-
0034981271
-
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat
-
Butler AA, Marks DL, Fan W, et al. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 2001; 4:605-611.
-
(2001)
Nat Neurosci
, vol.4
, pp. 605-611
-
-
Butler, A.A.1
Marks, D.L.2
Fan, W.3
-
10
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
Chen AS, Marsh DJ, Trumbauer ME, et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26:97-102.
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
-
11
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
Butler AA, Kesterson RA, Khong K, et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000; 141:3518-3521.
-
(2000)
Endocrinology
, vol.141
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
-
12
-
-
0030678119
-
Independent and additive effects of central POMC and leptin pathways on murine obesity
-
Boston BA, Blaydon KM, Varnerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997; 278:1641-1644.
-
(1997)
Science
, vol.278
, pp. 1641-1644
-
-
Boston, B.A.1
Blaydon, K.M.2
Varnerin, J.3
Cone, R.D.4
-
13
-
-
0032900284
-
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
-
Marsh DJ, Hollopeter G, Husiar D, et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 1999; 21:119-122.
-
(1999)
Nat Genet
, vol.21
, pp. 119-122
-
-
Marsh, D.J.1
Hollopeter, G.2
Husiar, D.3
-
14
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, Coppari R, McMinn J, et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004; 42:983-991. An excellent study investigating a key question in energy homeostasis. The techniques outlined will prove to be powerful tools in further delineating the neural circuits mediating leptin's effect.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
-
15
-
-
12144291698
-
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
-
Challis BG, Coll AP, Yeo GS, et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci U S A 2004; 101:4695-4700. Evidence that loss of a single copy of Pomc is sufficient to render mice susceptible to obesity on a high fat diet and so highlighting this locus as a site for gene-environment interactions predisposing to obesity.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4695-4700
-
-
Challis, B.G.1
Coll, A.P.2
Yeo, G.S.3
-
16
-
-
0036125112
-
Pro-opiomelanocortin processing in the hypothalamus: Impact on melanocortin signalling and obesity
-
Pritchard LE, Turnbull AV, White A. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. J Endocrinol 2002; 172:411-421.
-
(2002)
J Endocrinol
, vol.172
, pp. 411-421
-
-
Pritchard, L.E.1
Turnbull, A.V.2
White, A.3
-
17
-
-
4143090543
-
N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
-
Guo L, Munzberg H, Stuart RC, et al. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci U S A 2004; 101:11797-11802. Data demonstrating that leptin induces hypothalamic N-acetyltransferase activity, resulting in increased levels of the highly stable and potent MSH analogue. N-acetylated-α-MSH. The identification of the enzymes involved may provide novel targets for therapeutic intervention.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11797-11802
-
-
Guo, L.1
Munzberg, H.2
Stuart, R.C.3
-
18
-
-
9644307899
-
Melanocortin-independent effects of leptin on hepatic glucose fluxes
-
Gutierrez-Juarez R, Obici S, Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem 2004; 279:49704-49715. Building upon their previous data linking the leptin-melanocortin system and glucose homeostasis, this group has now carried out a highly detailed study into the mechanisms by which leptin can stimulate gluconeogenesis and inhibit glycolysis.
-
(2004)
J Biol Chem
, vol.279
, pp. 49704-49715
-
-
Gutierrez-Juarez, R.1
Obici, S.2
Rossetti, L.3
-
19
-
-
0033781032
-
Cholecystokinin and satiety: Current perspectives
-
Moran TH. Cholecystokinin and satiety: current perspectives. Nutrition 2000; 16:858-865.
-
(2000)
Nutrition
, vol.16
, pp. 858-865
-
-
Moran, T.H.1
-
20
-
-
1842560331
-
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
-
Fan W, Ellacott KL, Halatchev IG, et al. Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system. Nat Neurosci 2004; 7:335-336. Evidence that the melanocortin system may integrate short-term satiety signals as well as long-term adipostatic signals.
-
(2004)
Nat Neurosci
, vol.7
, pp. 335-336
-
-
Fan, W.1
Ellacott, K.L.2
Halatchev, I.G.3
-
21
-
-
0037043704
-
Gut hormone PYY(3-36) physiologically inhibits food intake
-
Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002; 418:650-654.
-
(2002)
Nature
, vol.418
, pp. 650-654
-
-
Batterham, R.L.1
Cowley, M.A.2
Small, C.J.3
-
22
-
-
0041859261
-
Inhibition of food intake in obese subjects by peptide YY3-36
-
Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349:941-948.
-
(2003)
N Engl J Med
, vol.349
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
-
23
-
-
3442879939
-
Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin
-
Martin NM, Small CJ, Sajedi A, et al. Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin. Int J Obes Relat Metab Disord 2004; 28:886-893. In addition to demonstrating that Agouti mice are sensitive to PYY 3-36, results showing that there may be a role for the melanocortin system in mediating ghrelin's effects.
-
(2004)
Int J Obes Relat Metab Disord
, vol.28
, pp. 886-893
-
-
Martin, N.M.1
Small, C.J.2
Sajedi, A.3
-
24
-
-
2542444495
-
Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism
-
Halatchev IG, Ellacott KL, Fan W, Cone RD. Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 2004; 145:2585-2590. Insightful observations into the need to acclimatize mice to handling and injections in order to reliably achieve a reduction in food intake with PYY 3-36.
-
(2004)
Endocrinology
, vol.145
, pp. 2585-2590
-
-
Halatchev, I.G.1
Ellacott, K.L.2
Fan, W.3
Cone, R.D.4
-
25
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
-
Qu D, Ludwig DS, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380:243-247.
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.S.2
Gammeltoft, S.3
-
26
-
-
0034607053
-
Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system
-
Hanada R, Nakazato M, Matsukura S, et al. Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem Biophys Res Commun 2000; 268:88-91.
-
(2000)
Biochem Biophys Res Commun
, vol.268
, pp. 88-91
-
-
Hanada, R.1
Nakazato, M.2
Matsukura, S.3
-
27
-
-
0034653422
-
BDNF regulates eating behavior and locomotor activity in mice
-
Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19:1290-1300.
-
(2000)
EMBO J
, vol.19
, pp. 1290-1300
-
-
Kernie, S.G.1
Liebl, D.J.2
Parada, L.F.3
-
28
-
-
0034792085
-
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
-
Rios M, Fan G, Fekete C, et al. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 2001; 15:1748-1757.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1748-1757
-
-
Rios, M.1
Fan, G.2
Fekete, C.3
-
29
-
-
0035985245
-
Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice
-
N'akagawa T, Ono-Kishino M, Sugaru E, et al. Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice. Diabetes Metab Res Rev 2002; 18:185-191.
-
(2002)
Diabetes Metab Res Rev
, vol.18
, pp. 185-191
-
-
N'akagawa, T.1
Ono-Kishino, M.2
Sugaru, E.3
-
30
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
Xu B, Goulding EH, Zang K, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6:736-742.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-742
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
-
31
-
-
8544226258
-
Induction of brain region-specific forms of obesity by Agouti
-
Kas MJ, Tiesjema B, van Dijk G, et al. Induction of brain region-specific forms of obesity by Agouti. J Neurosci 2004; 24:10176-10181. Data suggesting that the melanocortin system can regulate different adaptive strategies to alter an organism's energy balance.
-
(2004)
J Neurosci
, vol.24
, pp. 10176-10181
-
-
Kas, M.J.1
Tiesjema, B.2
Van Dijk, G.3
-
32
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998; 19:155-157.
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
-
33
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude H, Biebermann H, Schnabel D, et al. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003; 88:4633-4640.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
-
34
-
-
4644240052
-
Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians
-
Ma L, Tataranni PA, Bogardus C, Baier LJ. Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians. Diabetes 2004; 53:2696-2699.
-
(2004)
Diabetes
, vol.53
, pp. 2696-2699
-
-
Ma, L.1
Tataranni, P.A.2
Bogardus, C.3
Baier, L.J.4
-
35
-
-
12244281827
-
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity
-
Larsen LH, Echwald SM, Sorensen TI, et al. Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab 2005; 90:219-224. An important contribution to the debate regarding the true prevalence of pathogenic MC4R variants in the general unselected population.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 219-224
-
-
Larsen, L.H.1
Echwald, S.M.2
Sorensen, T.I.3
-
36
-
-
0036963510
-
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
-
Lee YS, Poh LK, Loke KY. A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. J Clin Endocrinol Metab 2002; 87:1423-1426.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1423-1426
-
-
Lee, Y.S.1
Poh, L.K.2
Loke, K.Y.3
-
37
-
-
3242795783
-
Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity
-
Rached M, Buronfosse A, Begeot M, Penhoat A. Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. Biochim Biophys Acta 2004; 1689:229-234.
-
(2004)
Biochim Biophys Acta
, vol.1689
, pp. 229-234
-
-
Rached, M.1
Buronfosse, A.2
Begeot, M.3
Penhoat, A.4
-
38
-
-
4043093705
-
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
-
Tao YX, Segaloff DL. Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab 2004; 89:3936-3942.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3936-3942
-
-
Tao, Y.X.1
Segaloff, D.L.2
-
39
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
Yeo GS, Connie Hung CC, Rochford J, et al. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004; 7:1187-1189. First report of a unique human syndrome of hyperphagic obesity.
-
(2004)
Nat Neurosci
, vol.7
, pp. 1187-1189
-
-
Yeo, G.S.1
Connie Hung, C.C.2
Rochford, J.3
-
40
-
-
16544371717
-
Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22
-
Cai G, Cole SA, Bastarrachea-Sosa RA, et al. Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. Am J Clin Nutr 2004; 80:1410-1414. These results suggest that this chromosomal region might contribute to dietary macronutrient intakes and adiposity phenotypes in Mexican Americans.
-
(2004)
Am J Clin Nutr
, vol.80
, pp. 1410-1414
-
-
Cai, G.1
Cole, S.A.2
Bastarrachea-Sosa, R.A.3
-
41
-
-
12144289073
-
Melanocortin-4 receptor gene variant 1103 is negatively associated with obesity
-
Geller F, Reichwald K, Dempfle A, et al. Melanocortin-4 receptor gene variant 1103 is negatively associated with obesity. Am J Hum Genet 2004; 74:572-581.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
Reichwald, K.2
Dempfle, A.3
-
42
-
-
1842458464
-
Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans
-
Marks DL, Boucher N, Lanouette CM, et al. Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans. Am J Med Genet A 2004; 126:267-271. First demonstration of an association between the presence of a putative recessive allele and a lean phenotype in an otherwise healthy human population.
-
(2004)
Am J Med Genet A
, vol.126
, pp. 267-271
-
-
Marks, D.L.1
Boucher, N.2
Lanouette, C.M.3
-
43
-
-
9644279627
-
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
-
Srinivasan S, Lubrano-Berthelier C, Govaerts C, et al. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest 2004; 114:1158-1164. An investigation into obesity-associated mutations lying within the N-terminal (NT) domain of MC4-R which in vitro do not impair ligand binding. The results suggest a novel molecular mechanism potentially at work within the MC4-R.
-
(2004)
J Clin Invest
, vol.114
, pp. 1158-1164
-
-
Srinivasan, S.1
Lubrano-Berthelier, C.2
Govaerts, C.3
-
44
-
-
0344412889
-
Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization
-
Biebermann H, Krude H, Elsner A, et al. Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes 2003; 52:2984-2988.
-
(2003)
Diabetes
, vol.52
, pp. 2984-2988
-
-
Biebermann, H.1
Krude, H.2
Elsner, A.3
-
46
-
-
0042767613
-
Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats
-
Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 2003; 52:1951-1957.
-
(2003)
Diabetes
, vol.52
, pp. 1951-1957
-
-
Li, G.1
Mobbs, C.V.2
Scarpace, P.J.3
-
47
-
-
3843114437
-
Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice
-
Savontaus E, Breen TL, Kim A, et al. Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 2004; 145:3881-3891. This report supports the notion that chronic activation of the melanocortin system may serve as an effective strategy for the treatment of obesity and impaired glucose tolerance.
-
(2004)
Endocrinology
, vol.145
, pp. 3881-3891
-
-
Savontaus, E.1
Breen, T.L.2
Kim, A.3
-
48
-
-
0033779983
-
Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Meianotan II
-
Wessells H, Levine N, Hadley ME, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Meianotan II. Int J Impot Res 2000; 12(Suppl 4):S74-S79.
-
(2000)
Int J Impot Res
, vol.12
, Issue.SUPPL. 4
-
-
Wessells, H.1
Levine, N.2
Hadley, M.E.3
-
49
-
-
2342453337
-
Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra
-
Rosen RC, Diamond LE, Earle DC, et al. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res 2004; 16:135-142.
-
(2004)
Int J Impot Res
, vol.16
, pp. 135-142
-
-
Rosen, R.C.1
Diamond, L.E.2
Earle, D.C.3
-
50
-
-
12144285830
-
Identification of 2-[2-[2-(5-bromo-2-methoxyphenyl)-ethyl]-3- fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model
-
Vos TJ, Caracoti A, Che JL, et al. Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem 2004; 47:1602-1604.
-
(2004)
J Med Chem
, vol.47
, pp. 1602-1604
-
-
Vos, T.J.1
Caracoti, A.2
Che, J.L.3
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