Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes

Shock

Volumn 10, Issue 4, 1998, Pages 298-360

  Wang, Li ^a   Luo, Guang Ju ^a   Wang, Jing Jing ^a   Hasselgren, Per Olof ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALPAIN; CATHEPSIN B; CATHEPSIN D; CHLOROQUINE; CYSTEINE PROTEINASE; DEOXYGLUCOSE; DEXAMETHASONE; DRUG DERIVATIVE; LEUCINE; LEUPEPTIN; METHYLAMINE; MIFEPRISTONE; MULTIENZYME COMPLEX; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEASOME; PROTEIN; TYROSINE; UBIQUITIN;

ANIMAL; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; RAT; SKELETAL MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CALPAIN; CATHEPSIN B; CATHEPSIN D; CELLS, CULTURED; CHLOROQUINE; CYSTEINE ENDOPEPTIDASES; DEOXYGLUCOSE; DEXAMETHASONE; LEUCINE; LEUPEPTINS; METHYLAMINES; MIFEPRISTONE; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; RATS; TYROSINE; UBIQUITINS;

EID: 0032185015     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199810000-00011     Document Type: Article

References (42)

1. τ-methylhistidine. Biochem J 178:139-146, 1979.
2. τ-methylhistidine excretion. Biochem J 220:469-479, 1984.
3. Odedra BR, Bates PC, Millward DJ: Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochem J 214:617-627, 1983.
4. Tiao G, Fagan J, Roegner V, Lieberman M, Wang JJ, Fischer JE, Hasseigren PO: Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 97:339-348, 1996.
5. Auclair D, Garrel DR, Chaouki-Zerouala A, Ferland LH: Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids. Am J Physiol 272:C1007-C1016, 1997.
6. Ballard FJ, Francis GL: Effects of anabolic agents on protein breakdown in L6 myoblasts. Biochem J 210:243-249, 1983.
7. Hong DH, Forsberg NE: Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures. Mol Cell Endocrinol 108:199-209, 1995.
8. 3 H1 myocytes require an interaction between glucocorticoids and acidification. Proc Natl Acad Sci USA 93:1967-1971, 1996.
9. Wing SS, Goldberg AL: Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting. Am J Physiol 264:E668-E676, 1993.
10. Price SR, England BK, Bailey JL, VanVreede K, Mitch WE: Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle. Am J Physiol 267:C955-C960, 1994.
11. Lowry OH, Rosebrough NJ, Farr AL, Randell RJ: Protein measurements with the folin phenol agent. J Biol Chem 193:265-275, 1951.
12. Hasseigren PO: Methods commonly used to study protein metabolism. In Hasselgren PO: Protein metabolism in Sepsis. Austin, TX: RG Landes Co. pp 10-33.
13. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
14. Tiao GM, Pagan JM, Samuels N, et al: Sepsis stimulates non-lysosomal energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J Clin Invest 94:2255-2264, 1994.
15. Hall-Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE: Effect of the glucocorticoid receptor antagonist RU38486 on muscle protein breakdown in sepsis. Surgery 109:468-473, 1991.
16. Lowell BB, Ruderman NG, Goodman MN: Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle. Biochem J 234:237-240, 1986.
17. Hershko A, Ciechanover A: The ubiquitin system for protein degradation. Annu Rev Biochem 61:761-807, 1992.
18. Hasselgren PO, Fischer JE: The ubiquitin-proteasome pathway: Review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions. Ann Surg 225:307-316, 1997.
19. Abu-Shakra S, Alhalabi MS, Nachtman FC, Schemidt RA, Bensilow WSA: Anabolic steroids induce injury and apoptosis of differentiated skeletal muscle. J Neurosci Res 47:186-197, 1997.
20. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Huang D, Goldberg AL: Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771, 1994.
21. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL: Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726-731, 1995.
22. Dick LR, Cruikshank AA, Grenier L, Melandri FD, Numes SL, Stein RL: Mechanistic studies on the inactivation of the proteasome by lactacystin: A central role for clastolactacystin beta-lactone. J Biol Chem 271:7273-7276, 1996.
23. Tanaka K: Molecular biology of proteasomes. Mol Biol Rep 21:21-26, 1995.
24. Tiao G, Pagan J, Lieberman M, Fischer JE, Hasselgren PO: Sepsis increases proteasome-dependent proteolysis and mRNA levels for the proteasome subunit RC3 in skeletal muscles. Surg Forum 46:10-12, 1995.
25. Tiao G, Hobler S, Wang JJ, Meyer TA, Luchette FA, Fischer JE, Hasselgren PO: Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J Clin Invest 99:163-168, 1997.
26. Dardavet D, Sornet C, Taillandier D, Savary I, Attaix D, Grizard J: Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats: Lack of regulation in the ubiquitin-proteasome proteolytic pathway in aging. J Clin Invest 96:2113-2119, 1995.
27. Bailey JL, Wang X, England BK, Price SR, Ding X, Mitch WE: The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest 97:1447-1453, 1996.
28. Pagano M: Cell cycle regulation by the ubiquitin pathway. FASEB J 11:1067-1075, 1997.
29. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NFκB1 precursor protein and the activation of NFκB. Cell 78:773-785, 1994.
30. Fang CH, James JH, Ogle C, Fischer JE, Hasselgren PO: Influence of burn injury on protein metabolism in different types of skeletal muscle tissue and the role of glucocorticoids. J Am Coll Surg 180:33-42, 1995.
31. Kayali AG, Young VR, Goodman MN: Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis. Am J Physiol 252:E621-E626, 1987.
32. Hasselgren PO, James JH, Benson DW, et al: Total and myofibrillar protein breakdown in different types of rat skeletal muscle: Effects of sepsis and regulation by insulin. Metabolism 38:634-640, 1989.
33. Zamir O, Hasselgren PO, Kunkel SL, Frederick JA, Higashiguchi T, Fischer JE: Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis. Arch Surg 127:170-174, 1992.
34. Zamir O, O'Brien W, Thompson R, Bloedow DC, Fischer JE, Hasseigren PO: Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist. Int J Biochem 26:943-950, 1994.
35. Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE: Tumor necrosis factor (TNF) and interleukin-1 (IL-1) induce muscle proteolysis through different mechanisms. Med Inflam 1:247-250, 1992.
36. Hall-Angerås M, Angerås U, Hasselgren PO, Fischer JE: Corticosterone alone does not explain increased muscle proteolysis in septic rats. J Surg Res 48:368-372, 1990.
37. Fang CH, Tiao G, James JH, Ogle C, Fischer JE, Hasselgren PO: Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway. J Am Coll Surg 180:161-170, 1995.
38. Medina R, Wing SS, Haas A, Goldberg AL: Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy. Biomed Biochim Acta 50:347-356, 1991.
39. Baracos VE, DeVivo C, Hoyle DH, Goldberg AL: Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma. Am J Physiol 268:E996-E1006, 1995.
40. Hobler SC, Tiao G, Fischer JE, Monaco J, Hasselgren PO: The sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors. Am J Physiol 274:R30-R37, 1998.
41. Fang CH, Wang JJ, Hobler S, Li BG, Fischer JE, Hasselgren PO: Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats. Clin Sci, in press.
42. Smith DR, Toft DO: Steroid receptors and their associated proteins. Mol Endocrinol 7:4-11, 1993.