α-Synuclein-positive structures induced in leupeptin-infused rats

Brain Research

Volumn 1040, Issue 1-2, 2005, Pages 73-80

  Nakajima, T ^a   Takauchi, S ^b   Ohara, K ^a   Kokai, M ^a   Nishii, R ^a   Maeda, S ^a   Takanaga, A ^a   Tanaka, T ^c   Takeda, M ^c   Seki, M ^a   Morita, Y ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY OF HEALTH AND SPORT SCIENCES   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Immunoelectron microscopy; Immunohistochemistry; Leupeptin; Protease inhibitor; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; LEUPEPTIN; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN TISSUE; BRAIN VENTRICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FIMBRIA; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; INFUSION PUMP; NERVE ENDING; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RAT;

EID: 20144389841     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.01.099     Document Type: Article

References (33)

1. S. Baba, S. Nakajo, P.H. Tu, T. Tomita, K. Nakaya, V.M.Y. Lee, J.Q. Trojanowski, and T. Iwatsubo Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies Am. J. Pathol. 152 4 1998 879 884
2. M.C. Bennet, J.F. Bishop, Y. Leng, P.B. Chock, T.N. Chase, and M.M. Mouradian Degradation of α-synuclein by proteasome J. Biol. Chem. 274 1999 33855 33858
3. R. Betarbet, T.B. Sherer, G. MacKenzie, M. Garcia-Osuna, A.V. Panov, and J.T. Greenamyre Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nat. Neurosci. 3 2000 1301 1306
4. J.B. Cavanagh, C.C. Nolan, M.P. Seville, V.E.R. Anderson, and P.N. Leigh Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry J. Neurocytol. 22 1993 779 791
5. M.B. Feany, and W.W. Bender A Drosophila model of Parkinson's disease Nature 404 2000 341 343
6. M.C. Irizarry, W. Growdon, T. Gomez-Isla, K. Newell, J.M. George, D.F. Clayton, and B.T. Hyman Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity J. Neuropathol. Exp. Neurol. 57 1998 334 337
7. G.O. Ivy, F. Schottler, J. Wenzel, M. Baudry, and G. Lynch Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain Science 226 1984 985 987
8. A. Iwai, E. Masliah, M. Yoshimoto, N. Ge, L. Flanagan, H.A.R. Silva, A. Kittel, and T. Saitoh The precursor protein of Non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system Neuron 14 1995 467 475
9. R. Jakes, M.G. Spillantini, and M. Goedert Identification of two distinct synucleins from human brain FEBS Lett. 345 1993 27 32
10. N.R. Jana, E.A. Zemskov, G.h. Wang, and N. Nukina Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release Hum. Mol. Genet. 10 2001 1049 1059
11. E. Junn, S.S. Lee, U.T. Suhr, and M.M. Mouradian Parkin accumulation in aggresomes due to proteasome impairment J. Biol. Chem. 277 2002 47870 47877
12. J.N. Keller, K.B. Hanni, and W.R. Markesbery Impaired proteasome function in Alzheimer's disease J. Neurochem. 75 2000 436 439
13. K. Kosaka Diffuse Lewy body disease in Japan J. Neurol. 237 1990 197 204
14. R. Krüger, W. Kuhn, T. Müller, D. Woitalla, M. Graeber, S. Kösel, H. Przuntek, J.T. Epplen, L. Schöls, and O. Riess Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease Nat. Genet. 18 1998 106 108
15. H.J. Lee, and S.J. Lee Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells J. Biol. Chem. 277 2002 48976 48983
16. E. Masliah, E. Rockenstein, I. Veinbergs, M. Mallory, M. Hashimoto, A. Takeda, Y. Sagara, A. Sisk, and L. Mucke Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders Science 287 2000 1265 1269
17. E. Masliah, A. Iwai, M. Mallory, K. Ueda, and T. Saitoh Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease Am. J. Pathol. 148 1996 201 210
18. K.S.P. McNaught, and P. Jenner Proteasomal function is impaired in substantia nigra in Parkinson's disease Neurosci. Lett. 297 2001 191 194
19. A. Musial, and T. Eissa Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway J. Biol. Chem. 276 2001 24268 24273
20. R.J. Perrin, J.E. Payton, D.H. Barnett, C.L. Wraight, W.S. Woods, L. Ye, and J.M. George Epitope mapping and specificity of the anti-α-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines Neurosci. Lett. 349 2003 133 135
21. K. Petersen, O.F. Olesen, and J.D. Mikkelsen Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortex Neuroscience 91 1999 651 659
22. M.H. Polymeropoulos, C. Lavedan, E. Leroy, S.E. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E.S. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W.G. Johnson, A.M. Lazzarini, R.C. Duvoisin, G. Di Iorio, L.I. Golbe, and R.L. Nussbaum Mutations in the α-synuclein identified families with Parkinson's disease Science 276 1997 2045 2048
23. H.J. Rideout, K.E. Larsen, D. Sulzer, and L. Stefanis Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells J. Neurochem. 78 2001 899 908
24. P.J. Savory, and A.J. Rivett Leupeptin-binding site(s) in the mammalian multicatalytic proteinase Biochem. J. 289 1993 45 48
25. T.B. Sherer, J.H. Kim, R. Betarbet, and J.T. Greenamyre Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and α-synuclein aggregation Exp. Neurol. 179 2003 9 16
26. M.G. Spillantini, M.L. Schmidt, V.M.Y. Lee, J.Q. Trojanowski, R. Jakes, and M. Goedert α-Synuclein in Lewy bodies Nature 388 1997 838 840
27. S. Takauchi, and K. Miyoshi Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin Acta Neuropathol. 78 1989 380 387
28. S. Takauchi, and K. Miyoshi Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin Acta Neuropathol. 89 1995 8 16
29. G.K. Tofaris, R. Layfield, and M.G. Spillantini Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome FEBS Lett. 509 2001 22 26
30. M. Vila, S. Vukosavic, V. Jachson-Lewis, M. Neystat, M. Jakowec, and S. Przedborski α-Synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the Parkinsonian toxin MPTP J. Neurochem. 74 2000 721 729
31. K. Wakabayashi, M. Yoshimoto, S. Tsuji, and H. Takahashi α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy Neurosci. Lett. 249 1998 180 182
32. O. Yokota, S. Terada, H. Ishizu, K. Tsuchiya, Y. Kitamura, K. Ikeda, K. Ueda, and S. Kuroda NACP/α-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC) Acta Neuropathol. 104 2002 333 341
33. J.J. Zarranz, J. Alegre, J.C. Gomez-Esteban, E. Lezcano, R. Ros, I. Ampuero, L. Vidal, J. Hoenicka, O. Rodriguez, B. Atares, V. Llorens, E.G. Torrosa, T. Ser, D.G. Munoz, and J.G. Yebenes The new mutation, E46K, of a-synuclein causes Parkinson and Lewy body dementia Ann. Neurol. 55 2004 164 173