The kinetic status of hematopoietic stem cell subpopulations underlies a differential expression of genes involved in self-renewal, commitment, and engraftment

Stem Cells

Volumn 23, Issue 4, 2005, Pages 496-506

  Manfredini, Rossella ^a   Zini, Roberta ^a   Salati, Simona ^a   Siena, Michela ^a   Tenedini, Elena ^a   Tagliafico, Enrico ^a   Montanari, Monica ^a   Zanocco Marani, Tommaso ^a   Gemelli, Claudia ^a   Vignudelli, Tatiana ^a   Grande, Alexis ^a   Fogli, Miriam ^b   Rossi, Lara ^b   Fagioli, Maria Elena ^b   Catani, Lucia ^b   Lemoli, Roberto M ^b   Ferrari, Sergio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

CD34+ stem cells; CD34 ; Differentiation; Engraftment; Hematopoietic stem cells; Microarray Proliferation; Self renewal

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; CYTOKINE; DNA; FLT3 LIGAND; GAMMA INTERFERON; INTERLEUKIN 11; INTERLEUKIN 17; INTERLEUKIN 3; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 17; RNA; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL RENEWAL; CLONOGENIC ASSAY; COLONY FORMING UNIT; DNA MICROARRAY; DNA SYNTHESIS; ENGRAFTMENT; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; GENE MAPPING; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; KINETICS; LIQUID CULTURE; MOUSE; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SCID MOUSE; STEM CELL;

ANTIGENS, CD34; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CLUSTER ANALYSIS; CULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASES; CYCLINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; THROMBOPOIETIN;

ANIMALIA;

EID: 20144387852     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2004-0265     Document Type: Article

References (52)

1. Bhatia M, Bonnet D, Murdoch B et al. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 1998;4:1038-1045.
2. Sato T, Laver JH, Ogawa M. Reversible expression of CD34 by murine hematopoietic stem cells. Blood 1999;94:2548-2554.
3. Lemoli RM, Bertolini F, Petrucci MT et al. Functional and kinetic characterization of granulocytecolony-stimulating factor-primed. Br J Haematol 2003;123:720-729.
4. Dao MA, Arevalo J, Nolta JA. Reversibility of CD34 expression on human hematopoietic stem eel Is that retain the capacity for secondary reconstitution. Blood 2003;101:112-118.
5. + cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity. J Leukoc Biol 2004;75:314-323.
6. Wagner W, Ansorge A, Wirkner U et al. Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis. Blood 2004;104:675-686.
7. Georgantas RW III, Tanadve V, Malehorn M et al. Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells. Cancer Res 2004;64:4434-4441.
8. Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet 2000;1:57-64.
9. Brivanlou AH, Darnell JE Jr. Signal transduction and the control of gene expression. Science 2002;295:813-818.
10. Perrotti D, Bellon T, Trotta R et al. A cell proliferation-dependent multiprotein complex NC-3A positively regulates the CD34 promoter via a TCATTT-containing element. Blood 1996;88:3336-3348.
11. Dooley DC, Oppenlander BK, Xiao M. Analysis of primitive. STEM CELLS 2004;22:556-569.
12. + cell preparations contain over 100-fold greater NOD/SCID mouse engrafting capacity than do. Exp Hematol 2001;29:910-921.
13. + cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte colony-stimulating factor. Blood 1997;89:1189-1196.
14. Catani L, Gugliotta L, Campanini E et al. Megakaryocyte progenitors derived from bone marrow or G-CSF-mobilized peripheral blood CD34 cells show a distinct phenotype and responsiveness to interleukin-3 (IL-3) and PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). Br J Haematol 1998;100:207-218.
15. MacDonald RJ, Swift GH, Przybyla AE et al. Isolation of RNA using guanidinium salts. Methods Enzymol 1987;152:219-227.
16. Tagliafico E, Tenedini E, Bergamaschi A et al. Gene expression profile of Vitamin D3 treated HL60 cells shows an incomplete molecular phenotypic conversion to monocytes. Cell Death Differ 2002;9:1185-1195.
17. Doniger SW, Salomonis N, Dahlquist KD et al. MAPPFinder: using gene ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol 2003;4:R7.
18. Takahashi M, Seki N, Ozaki T et al. Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG. Cancer Res 2002;62:2203-2209.
19. Pignolo RJ, Francis MK, Rotenberg MO et al. Putative role for EPC-1/PEDF in the GO growth arrest of human diploid fibroblasts. J Cell Physiol 2003;195:12-20.
20. Steinman R, Yaroslavskiy B, Goff JP et al. Cdk-inhibitors and exit from quiescence in primitive haematopoietic cell subsets. Br J Haematol 2004;124:358-365.
21. Thullberg M, Bartkova J, Khan S et al. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors. FEBS Lett 2000;470:161-166.
22. O'Farrell AM, Parry DA, Zindy F et al. Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation. J Immunol 2000;164:4607-4615.
23. Sato T, Selleri C, Young NS et al. Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3. Blood 1997;90:4749-4758.
24. Fortunel N, Hatzfeld J, Kisselev S et al. Release from quiescence of primitive human hematopoietic stem/progenitor cells by blocking their cell-surface TGF-beta type II receptor in a short-term in vitro assay. STEM CELLS 2000;18:102-111.
25. Bielas JH, Heddle JA. Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair. DNA Repair (Amst) 2004;3:711-717.
26. Thomas G. An encore for ribosome biogenesis in the control of cell proliferation. Nat Cell Biol 2000;2:E71-E72.
27. Van den BC, Muus P, Haanen C et al. Mitochondrial biogenesis and mitochondrial activity during the progression of thecell cycle of human leukemic cells. Exp Cell Res 1988;178:143-153.
28. Kirito K, Fox N, Kaushansky K. Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. Blood 2003;102:3172-3178.
29. Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 1997;89:3636-3643.
30. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-260.
31. Zhu J, Emerson SG. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 2002;21:3295-3313.
32. Alani RM, Young AZ, Shifflett CB. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a. Proc Natl Acad Sci U S A 2001;98:7812-7816.
33. Crooks GM, Fuller J, Petersen D et al. Constitutive HOXA5 expression inhibits ery thropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood 1999;94:519-528.
34. Wadman IA, Osada H, Grutz GG et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997;16:3145-3157.
35. Shivdasani RA. Molecular and transcriptional regulation of megakaryocyte differentiation. STEM CELLS 2001;19:397-407.
36. Querfurth E, Schuster M, Kulessa H et al. Antagonism between C/EBP-beta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Genes Dev 2000;14:2515-2525.
37. Radomska HS, Huettner CS, Zhang P et al. CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol 1998;18:4301-4314.
38. Tamura T, Nagamura-Inoue T, Shmeltzer Z et al. ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 2000;13:155-165.
39. Krishnaraju K, Hoffman B, Liebermann DA. Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood 2001;97:1298-1305.
40. Taghon T, Stolz F, De Smedt M et al. HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood 2002;99:1197-1204.
41. Georgopoulos K. Transcription factors required for lymphoid lineage commitment. Curr Opin Immunol 1997;9:222-227.
42. Bowman EP, Campbell JJ, Druey KM et al. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. J Biol Chem 1998;273:28040-28048.
43. Calvo KR, Knoepfler PS, Sykes DB et al. Meis la suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A 2001;98:13120-13125.
44. Frenette PS, Subbarao S, Mazo IB et al. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A 1998;95:14423-14428.
45. + cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000;95:3289-3296.
46. Levesque JP, Hendy J, Takamatsu Y et al. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 2003;111:187-196.
47. - sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation. Blood 2002;100:2778-2786.
48. + progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood 2004;103:2942-2949.
49. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003;102:3483-3493.
50. Takano H, Ema H, Sudo K et al. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 2004;199:295-302.
51. Quesenberry PJ, Colvin GA, Abedi M et al. The marrow stem cell: the continuum. Bone Marrow Transplant 2003;32(suppl 1):S19-S22.
52. Lambert JF, Liu M, Colvin GA et al. Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit. J Exp Med 2003;197:1563-1572.