α3β1 integrin induced suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-κB activation

Cellular Immunology

Volumn 231, Issue 1-2, 2004, Pages 30-39

  Li, Gongchu ^a   Lubin, Farah D ^a   McGee, Dennis W ^a  

^a BINGHAMTON UNIVERSITY   (United States)

Author keywords

3 1 integrin; I B ; IKK; IL 1; Intestinal epithelial cell; Intracellular signaling; Laminin 5; NF B

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; VERY LATE ACTIVATION ANTIGEN 3; ANTIBODY; CELL EXTRACT; CHUK PROTEIN, HUMAN; FIBRONECTIN; I KAPPA B; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; LAMININ; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL STRAIN CACO 2; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL NUCLEUS; DRUG EFFECT; DRUG POTENTIATION; ENZYME SPECIFICITY; IMMUNOLOGY; METABOLISM;

ANTIBODIES; CACO-2 CELLS; CELL EXTRACTS; CELL NUCLEUS; FIBRONECTINS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTEGRIN ALPHA3BETA1; INTERLEUKIN-1; LAMININ; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 20144384643     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellimm.2004.11.004     Document Type: Article

References (33)

1. L. Eckman, H.C. Jung, C. Schurer-Maly, A. Panja, E. Morzycka-Wroblewska, and M.F. Kagnoff Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin-8 Gastroenterology 105 1993 1689 1697
2. D.W. McGee, K.W. Beagley, W.K. Aicher, and J.R. McGhee Transforming growth factor-β and IL-1β act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6 J. Immunol. 151 1993 970 978
3. H.C. Jung, L. Eckmann, S.K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M.F. Kagnoff A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion J. Clin. Invest. 95 1995 55 65
4. H.C. Reinecker, E.Y Loh, D.J. Ringler, A. Mehta, J.L. Rombeau, and R.P. MacDermott Monocyte-chemoattractant protein-1 gene expression in intestinal epithelial cells and inflammatory bowel disease Gastroenterology 108 1995 40 45
5. J.-F. Beaulieu Integrins and human intestinal cell functions Front. Biosci. 4 1999 d310 d321
6. B. Wehrle-Haller, and B.A. Imhof The inner lives of focal adhesions Trends Cell Biol. 12 2002 382 389
7. R.L. Juliano Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrin, cadherins, selectins, and immunoglobulin-superfamily members Annu. Rev. Pharmacol. Toxicol. 42 2002 283 323
8. L.E. Goldfinger, S.B. Hopkinson, G.W. deHart, S. Gollawn, J.R. Couchman, and J.C.R. Jones The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin J. Cell Sci. 112 1999 2615 2629
9. B.P. Nguyen, M.C. Ryan, S.G. Gil, and W.G. Carter Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion Curr. Opin. Cell Biol. 12 2000 554 562
10. E.C. Ebert Mechanisms of colon cancer binding to substratum and cells Dig. Dis. Sci. 41 1996 1551 1556
11. V. Orian-Rousseau, D. Aberdam, P. Rousselle, A. Messent, J. Gavrilovic, G. Meneguzzi, M. Kedinger, and P. Simon-Assmann Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin α2β1 J. Cell Sci. 111 1998 1993 2004
12. M.M. Lotz, A. Nusrat, J.L. Madara, R. Ezzell, U.M. Wewer, and A.M. Mercurio Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium Am. J. Pathol. 150 1997 747 760
13. F.D. Lubin, M. Segal, and D.W. McGee Regulation of epithelial cell cytokine responses by the α3β1 integrin Immunology 108 2003 204 210
14. M. Baggiolini, B. Dewald, and B. Moser Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines Adv. Immunol. 55 1994 97 179
15. T. Kishimoto, S. Akira, M. Narazaki, and T. Taga Interleukin-6 family of cytokines and gp130 Blood 86 1995 1243 1254
16. T. Martin, P.M. Cardarelli, G.C.N. Parry, K.A. Felts, and E.R. Cobb Cytokine induction of monocyte chemochemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-κB and AP-1 Eur. J. Immunol. 27 1997 1091 1097
17. C. Jobin, and R.B. Sartor The IκB/NF-κB system: a key determinant of mucosal inflammation and protection Am. J. Physiol. 278 2000 C451 C462
18. A. Baldwin NF-κB and IκB proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 681
19. G. Rogler, K. Brand, D. Vogl, S. Page, R. Hofmeiste, T. Andus, R. Knuechel, J.S. Baeuerle, and V. Gross Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa Gastroenterology 115 1998 357 369
20. C. Jobin, S. Haskill, L. Mayer, A. Panja, and R.B. Sartor Evidence for altered regulation of IκBα degradation in human colonic epithelial cells J. Immunol. 158 1997 226 234
21. L.A.J. O'Neill, and C. Greene Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants J. Leukoc. Biol. 63 1998 650 657
22. J.A. DiDonato, M. Hayakawa, D.M. Rothwarf, E. Zandi, and M. Karin A cytokine-responsive IκB kinase that activates the transcription factor NF-κB Nature 388 1997 548 554
23. M. Delhase, M. Hayakawa, Y. Chen, and M. Karin Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation Science 284 1999 309 313
24. L.B. Ludwig, B.J. Hughes, and S.A. Schwartz Biotinylated probes in the electrophoretic shift assay to examine specific dsDNA, ssDNA or RNA-protein interactions Nucleic Acids Res. 23 1995 3792 3793
25. D. Elewaut, J.A. DiDonato, J.M. Kim, F. Truong, L. Eckmann, and M.K. Kagnoff NF-κB is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria J. Immunol. 163 1999 1457 1466
26. E. Zandi, and M. Karin Bridging the gap: composition, regulation and physiological function of the IκB kinase complex Mol. Cell. Biol. 19 1999 4547 4551
27. J.A. Kreidberg Functions of α3β1 integrin Curr. Opin. Cell Biol. 12 2000 548 553
28. B.P. Nguyen, X.-D. Ren, M.A. Schwartz, and W.G. Carter Ligation of integrin α3β1 by laminin 5 at the wound edge activates Rho-dependent adhesion of leading keratinocytes on collagen J. Biol. Chem. 276 2001 43860 43870
29. M. Gonzales, K. Haan, S.E. Baker, M. Fitchmun, I. Todorov, S. Weitzman, and J.C.R. Jones A cell signal pathway involving laminin-5, α3β1 integrin, and mitogen activated protein kinase can regulate epithelial cell proliferation Mol. Biol. Cell 10 1999 259 270
30. E.E. Qwarnstrom, C.O. Ostberg, G.L. Turk, A. Richardson, and K. Bomsztyk Fibronectin attachment activated the NF-κB p50/p65 heterodimer in fibroblasts and smooth muscle cells J. Biol. Chem. 269 1994 30765 30768
31. S. Klein, A.R. de Fougerolles, P. Blaikie, L. Kahn, A. Pepe, C.D. Green, V. Koteliansky, and F.G. Giancotti α5β1 integrin activates an NF-κB-dependent program of gene expression important for angiogenesis and inflammation Mol. Cell. Biol. 22 2002 5912 5922
32. M. Reyes-Reyes, N. Mora, A. Zentella, and C. Rosales Phosphatidylinositol 3-kinase mediates integrin-dependent NF-κB and MAPK activation through separate signaling pathways J. Cell Sci. 114 2001 1579 1598
33. V. Casini-Raggi, L. Kam, Y.J.T. Chong, C. Fiocchi, T.T. Pizarro, and F. Cominelli Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation J. Immunol. 154 1995 2434 2440