Functions of α3β1 integrin

Current Opinion in Cell Biology

Volumn 12, Issue 5, 2000, Pages 548-553

  Kreidberg, Jordan A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LAMININ RECEPTOR; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; TETRASPANIN; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

BASEMENT MEMBRANE; BRAIN DEVELOPMENT; CANCER INVASION; CARCINOGENESIS; CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; ELECTRON MICROSCOPY; EPITHELIUM CELL; KIDNEY DEVELOPMENT; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SKIN; TISSUE DISTRIBUTION; ANIMAL; CELL ADHESION; CELL MOTION; HUMAN; PHYSIOLOGY;

ANIMALS; CELL ADHESION; CELL MOVEMENT; HUMANS; INTEGRIN ALPHA3BETA1; INTEGRINS; SIGNAL TRANSDUCTION;

EID: 0033624331     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00130-7     Document Type: Review

References (62)

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2. Receptor functions for the integrin VLA-3: Fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations
3. A novel role for α3β1 integrins in extracellular matrix assembly
4. The receptor for the basement membrane glycoprotein entactin is the integrin α3β1
5. Isolation and characterization of laminin-10/11 secreted by human lung carcinoma cells. Laminin-10/11 mediates cell adhesion through integrin α3β1
6. Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes
7. Distinct and overlapping ligand specificities of the α3Aβ1 and α6Aβ1 integrins: Recognition of laminin isoforms
8. Thrombospondin-1 promotes α3β1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells
9. α3β1 integrin has a crucial role in kidney and lung organogenesis
10. Integrin expression during human epidermal development in vivo and in vitro
11. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
12. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice
13. α3β1 integrin is required for normal development of the epidermal basement membrane
14. Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes
15. A cell signal pathway involving laminin-5, α3β1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation
16. The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin
17. α3β1 and α6β4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development
18. The α1β6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron
19. Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane
20. The laminin α chains: Expression, developmental transitions, and chromosomal locations of α1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
21. Distinct functions of α3 and α(v) integrin receptors n neuronal migration and laminar organization of the cerebral cortex
22. Neuronal receptors mediating responses to antibody-activated laminin-1
23. Expression of integrins during liver organogenesis in humans
24. α3β1-integrin as a critical mediator of the hepatic differentiation response to the extracellular matrix
25. Cellular localization of α3β1 integrin isoforms in association with myofibrillogenesis during cardiac myocyte development in culture
26. Specific alterations in the expression of α3β1 and α6β4 integrins in highly invasive and metastatic variants of human prostate carcinoma cells selected by in vitro invasion through reconstituted basement membrane
27. Low expression of β1, α2 and α3 subunits of VLA integrins in malignant mammary tumours
28. Association of the decreased expression of α3β1 integrin with the altered cell: Environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells
29. N-myc over-expression downregulates α3β1 integrin expression in human Saos-2 osteosarcoma cells
30. Concomitant down-regulation of expression of integrin subunits by N-myc in human neuroblastoma cells: Differential regulation of α2, α3 and β1
31. Ultrastructural localization of α3 integrin subunit in malignant melanoma and adjacent epidermis
32. Migration of breast epithelial cells on Laminin-5: Differential role of integrins in normal and transformed cell types
33. Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma
34. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion
35. The role of integrins α2β1 and α3β1 in cell-cell and cell-substrate adhesion of human epidermal cells
36. α3β1 integrin regulates epithelial cytoskeletal organization
37. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that α3β1 complexes with EMMPRIN/basigin/OX47/M6
38. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase
39. Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin α3β1 at cell-cell contact sites
40. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 integrin localized at endothelial lateral junctions
41. Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration
42. An antibody to the tetraspan membrane protein CD9 promotes neurite formation in a partially α3β1 integrin-dependent manner
43. Transmembrane-4-superfamily protein, CD151, associates with α3β1 integrin and participates specifically in a α3β1-meidated NT2N neurite outgrowth
44. Characterization of integrin-tetraspanin adhesion complexes: Role of tetraspanins in integrin signaling
45. Anti-α3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells
46. Function of α3β1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2)
47. Immortalized mouse keratinocytes acquire a3b1 integrin-dependent production of MM9/gelatinase B
48. Reduced integrin α3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung
49. Localization of the alpha 3 beta 1 integrin in some common epithelial tumors of the ovary and in normal equivalents
50. Integrin expression on normal and neoplastic human breast epithelium
51. Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation
52. Differential expression of laminin-5 subunits and integrin receptors in human colorectal neoplasia
53. Immunolocalization of integrins in the normal and neoplastic colonic epithelium
54. Characterization of integrin receptors in normal and neoplastic human brain
55. Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas
56. Association of the tetraspan protein CD9 with integrins on the surface of S-16 Schwann cells
57. Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes
58. Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins)
59. Integrin α6A β1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate
60. Specific association of CD63 with the VLA-3 and VLA-6 integrins
61. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy
62. Reelin binds α3β1 integrin and inhibits neuronal migration