The gene encoding interleukin-13: A susceptibility locus for asthma and related traits

Respiratory Research

Volumn 1, Issue 1, 2000, Pages 19-23

  Wills Karp, Marsha ^a  

^a The Johns Hopkins University   (United States)

Author keywords

Asthma; Atopy; Genetics; Interleukin 13; Interleukin 4 receptor

Indexed keywords

ARGININE; CYTOKINE; GLYCINE; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; ATOPY; CHROMOSOME 5Q; CONTROLLED STUDY; DISEASE MODEL; ENVIRONMENTAL FACTOR; ETHNIC GROUP; GENE CLUSTER; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; HEREDITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; TH2 CELL;

ASTHMA; CHROMOSOMES, HUMAN, PAIR 5; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-13;

EID: 0034581505     PISSN: 14659921     EISSN: None     Source Type: Journal    
DOI: 10.1186/rr7     Document Type: Article

References (34)

1. A genome-wide search for quantitative trait loci underlying asthma
2. A genome-wide search for asthma susceptibility loci in ethnically diverse populations
3. Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma
4. A genome-wide search for linkage to asthma
5. Genome-wide screen for atopy susceptibility alleles in the Hutterites
6. Specific IgE - One gene fits all?
7. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
8. Genetic susceptibility to asthmabronchial hyperresponsiveness coinherited with a major gene for atopy
9. SSC polymorphisms in interleukin genes
10. Association between a sequence variant in the IL-4 gene promoter and FEV1 in asthma
11. Association of asthma and the interleukin-4 promoter gene in Japanese
12. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy
13. Genetic variants of IL-13 signalling and human asthma and atopy
14. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
15. Interleukin-13: Central mediator of allergic asthma
16. Requirement for IL-13 independently of IL-4 in experimental asthma
17. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
18. The role of IL-13 and its receptor in allergy and inflammatory responses
19. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
20. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
21. Kinetic analysis of high affinity forms of interleukin (IL)-13 receptors: Suppression of IL-13 binding by IL-2 receptor gamma chain
22. Interleukin-4 is required for the induction of lung Th2 mucosal immunity
23. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
24. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
25. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy
26. An IL-13 promoter polymorphism associated with increased risk of allergic asthma
27. Molecular regulation of cytokine gene expression during the immune response
28. The association of atopy with a gain-of-function mutation in the a-subunit of the interleukin-4 receptor
29. Linkage and allelic association of atopy and markers flanking the IL-4-receptor gene
30. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations
31. The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction
32. Cutting edge: Effects of an allergy-associated mutation in the human IL-4R (Q576R) on human IL-4-induced signal transduction
33. A polymorphism in the 5′-flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum IgE
34. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons