Superior activity of the type C class of ISS in vitro and in vivo across multiple species

DNA and Cell Biology

Volumn 24, Issue 2, 2005, Pages 63-72

  Marshall, Jason D ^a   Fearon, Karen L ^a   Higgins, Debbie ^a   Hessel, Edith M ^a   Kanzler, Holger ^a   Abbate, Christi ^a   Yee, Priscilla ^a   Gregorio, Josh ^a   Dela Cruz, Tracy ^a   Lizcano, Jennifer O ^a   Zolotorev, Alya ^a   McClure, Hazel M ^b   Brasky, Kathleen M ^b   Murthy, Krishna K ^b   Coffman, Robert L ^a   Van Nest, Gary ^a  

^a Dynavax Technologies Corporation   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1018; ALPHA INTERFERON; C 264; C 274; C 612; C 695; C 792; DOUBLE STRANDED DNA; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE; PALINDROMIC DNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL ACTIVITY; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IMMUNOSTIMULATORY SEQUENCE; IMMUNOTHERAPY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; CPG ISLANDS; CYTOKINES; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-12; INTERLEUKIN-6; LYMPH NODES; MICE; OLIGODEOXYRIBONUCLEOTIDES; PAPIO; RNA, MESSENGER; TRANSCRIPTION FACTORS;

ANIMALIA; PRIMATES;

EID: 19944431955     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2005.24.63     Document Type: Article

References (25)

1. BARTON, G.M., and MEDZHITOV, R. (2003). Linking Toll-like receptors to IFN-alpha/beta expression. Nat. Immunol. 4, 432-433.
2. BROIDE, D., SCHWARZE, J., TIGHE, H., GIFFORD, T., NGUYEN, M.D., MALEK, S., VAN UDEN, J., MARTIN-OROZCO, E., GELFAND, E.W., and RAZ, E. (1998). Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J. Immunol. 161, 7054-7062.
3. BROIDE, D.H., STACHNICK, G., CASTANEDA, D., NAYAR, J., MILLER, M., CHO, J.Y., ROMAN, M., ZUBELDIA, J., HYASHI, T., and RAZ, E. (2001). Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J. Clin. Immunol. 21, 175-182.
4. COATES, P.T., BARRATT-BOYES, S.M., ZHANG, L., DONNENBERG, V.S., O'CONNELL, P.J., LOGAR, A.J., DUNCAN, F.J., MURPHEY-CORB, M., DONNENBERG, A.D., MORELLI, A.E., et al. (2003). Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. Blood 102, 2513-2521.
5. DIEBOLD, S.S., KAISHO, T., HEMMI, H., AKIRA, S., and REIS, E.S.C. (2004). Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531.
6. DURAMAD, O., FEARON, K.L., CHAN, J.H., KANZLER, H., MARSHALL, J.D., COFFMAN, R.L., and BARRAT, F.J. (2003). IL-10 regulates plasmacytoid dendritic cell response to CpG containing immunostimulatory sequences. Blood 102, 4487-4492.
7. FEARON, K., MARSHALL, J.D., ABBATE, C., SUBRAMANIAN, S., YEE, P., GREGORIO, J., TESHIMA, G., OTT, G., TUCK, S., VAN NEST, G., et al. (2003). A minimal human immunostimulatory CpG motif that potently induces IFN-g and IFN-a production. Eur. J. Immunol. 33, 2114-2122.
8. HACKER, H., MISCHAK, H., MIETHKE, T., LIPTAY, S., SCHMID, R., SPARWASSER, T., HEEG, K., LIPFORD, G.B., and WAGNER, H. (1998). CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo. J. 17, 6230-6240.
9. HARTMANN, G., BATTIANY, J., POECK, H., WAGNER, M., KERKMANN, M., LUBENOW, N., ROTHENFUSSER, S., and ENDRES, S. (2003). Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur. J. Immunol. 33, 1633-1641.
10. HARTMANN, G., and KRIEG, A.M. (2000). Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164, 944-953.
11. HARTMANN, G., WEERATNA, R.D., BALLAS, Z.K., PAYETTE, P., BLACKWELL, S., SUPARTO, I., RASMUSSEN, W.L., WALDSCHMIDT, M., SAJUTHI, D., PURCELL, R.H., et al. (2000). Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J. Immunol. 164, 1617-1624.
12. IZAGUIRRE, A., BARNES, B.J., AMRUTE, S., YEOW, W.S., MEGJUGORAC, N., DAI, J., FENG, D., CHUNG, E., PITHA, P.M., and FITZGERALD-BOCARSLY, P. (2003). Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells. J. Leukoc. Biol. 74, 1125-1138.
13. KERKMANN, M., ROTHENFUSSER, S., HORNUNG, V., TOWAROWSKI, A., WAGNER, M., SARRIS, A., GIESE, T., ENDRES, S., and HARTMANN, G. (2003). Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170, 4465-4474.
14. KLINE, J.N., WALDSCHMIDT, T.J., BUSINGA, T.R., LEMISH, J.E., WEINSTOCK, J.V., THORNE, P.S., and KRIEG, A.M. 1998). Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160, 2555-2559.
15. KLINMAN, D.M. (2004). Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4, 249-259.
16. KRIEG, A.M. (1999). Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides. Biochim. Biophys. Acta. 1489, 107-116.
17. KRUG, A., LUKER, G.D., BARCHET, W., LEIB, D.A., AKIRA, S., and COLONNA, M. (2004). Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103, 1433-1437.
18. MARSHALL, J.D., FEARON, K., ABBATE, C., SUBRAMANIAN, S., YEE, P., GREGORIO, J., COFFMAN, R.L., and VAN NEST, G. (2003a). Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leukoc. Biol. 73, 781-792.
19. MARSHALL, J.D., HESSEL, E.M., GREGORIO, J., ABBATE, C., YEE, P., CHU, M., VAN NEST, G., COFFMAN, R.L., and FEARON, K.L. (2003b). Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells. Nucleic Acids Res. 31, 5122-5133.
20. MARSHALL, J.D., HIGGINS, D., ABBATE, C., YEE, P., TESHIMA, G., OTT, G., DELA CRUZ, T., PASSMORE, D., FEARON, K.L., TUCK, S., and VAN NEST, G. (2004). Polymyxin B enhances ISS-mediated immune responses across multiple species. Cell Immunol. 229, 93-105.
21. RONNBLOM, L., and ALM, G.V. (2001). A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J. Exp. Med. 194, F59-F63.
22. SANTELIZ, J.V., VAN NEST, G., TRAQUINA, P., LARSEN, E., and WILLS-KARP, M. (2002). Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol. 109, 455-462.
23. TAKEDA, K., KAISHO, T., and AKIRA, S. (2003). Toll-like receptors. Annu. Rev. Immunol. 21, 335-376.
24. VERTHELYI, D., ISHII, K.J., GURSEL, M., TAKESHITA, F., and KLINMAN, D.M. (2001). Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166, 2372-2377.
25. VOLLMER, J., WEERATNA, R., PAYETTE, P., JURK, M., SCHETTER, C., LAUCHT, M., WADER, T., TLUK, S., LIU, M., DAVIS, H.L., et al. (2004). Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur. J. Immunol. 34, 251-262.