Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours

Cancer Chemotherapy and Pharmacology

Volumn 55, Issue 2, 2005, Pages 117-128

  McSheehy, P M J ^a,b,c,d   Port, R E ^e   Rodrigues, L M ^a   Robinson, S P ^a   Stubbs, M ^a   Van Der Borns, K ^f   Peters, G J ^f   Judson, I R ^c   Leach, M O ^b   Griffiths, J R ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d NOVARTIS PHARMA AG   (Switzerland)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

5 fluorouracil; Carbogen; MRI; MRS; Pharmacokinetics; Tumour

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOGEN; FLUORONUCLEOTIDE; FLUOROURACIL; NUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD OXYGENATION; BLOOD SAMPLING; BREATHING; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG MECHANISM; DRUG METABOLISM; DRUG UPTAKE; ECHO PLANAR IMAGING; ENERGY; GENE CONSTRUCT; GENE LOCUS; LIVER CELL CARCINOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUDE MOUSE; OBSERVATION; PH; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROLACTINOMA; RAT; SIGNAL TRANSDUCTION; SOLID TUMOR; TUMOR BLOOD FLOW; XENOGRAFT;

ANIMALS; CARBON DIOXIDE; FLUOROURACIL; LIVER NEOPLASMS, EXPERIMENTAL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; OXYGEN; PROLACTINOMA; RATS; TRANSPLANTATION, HETEROLOGOUS;

EID: 19944428059     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0851-9     Document Type: Article

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