The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a

British Journal of Cancer

Volumn 78, Issue 11, 1998, Pages 1449-1456

  Stubbs, M ^a   Robinson, S P ^a   Rodrigues, L M ^a   Parkins, C S ^b   Collingridge, D R ^b,c   Griffiths, J R ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

31P magnetic resonance spectroscopy; Hepatoma; Metabolic profile; pH; pO2

Indexed keywords

CARBOGEN; CARBON DIOXIDE; GLUCOSE; LACTIC ACID; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD PH; CELL PH; GLUCOSE BLOOD LEVEL; HYPOXEMIA; LASER DOPPLER FLOWMETRY; MORRIS HEPATOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; TUMOR BLOOD FLOW;

EID: 0031771035     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.706     Document Type: Article

References (46)

1. Bergmeyer HU (1974) Methods of Enzymatic Analysis, 2nd edn. Verlag Chemie: Weinheim
2. Brizel DM, Lin S, Johnson JL, Brooks J, Dewhirst MW and Piantadosi CA (1995) The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. Br J Cancer 72: 1120-1124
3. Chaplin DJ and Hill SA (1995) Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br J Cancer 71: 1210-1213
4. Collingridge DR (1997) Measurement and manipulation of tumour oxygen tension. PhD Thesis, University of London
5. Dewhirst MW, Ong ET, Rosner GL, Rehmus SW, Shan S, Braun RD, Brizel DM and Secomb TW (1996). Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content. Br J Cancer 74: S241-S246
6. 1 and intracellular pH in the isolated working perfused rat heart. NMR Biomed 5: 2-28
7. Evans RD and Williamson DH (1988) Tissue-specific effects of rapid tumour growth on lipid metabolism in the rat during lactation and on litter removal. Biochem J 252: 65-72
8. 2 histography. Br J Cancer 66: 919-924
9. Folbergrova J, MacMillan V and Siesjo BK (1972) The effect of hypercapnic acidosis upon some glycolytic and Krebs cycle-associated intermediates in the rat brain. J Neurochem 19: 2507-2517
10. Gatenby RA (1995) The potential role of transformation-induced metabolic changes in tumor-host interaction. Cancer Res 55: 4151-4156
11. Gatenby RA and Gawlinski ET (1996) A reaction-diffusion model of cancer invasion. Cancer Res 56: 5745-5753
12. Gerweck LE and Seetharaman K (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 56: 1194-1198
13. 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol 267: (Cell Physiol. 36) C195-C203
14. Grau C, Horsman MR and Overgaard J (1992) Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen or carbogen breathing. Int J Radiat Oncol Biol Phys 22: 415-419
15. Gullino PM (1976) In vivo utilization of oxygen and glucose by neoplastic tissue. In Oxygen Transport to Tissue. II. Grote J, Reneau D and Thaws G (eds), pp. 521-536. Plenum: New York
16. Haase A, Frahm J, Matthaei D, Hanicke W and Merboldt K-D (1986) FLASH imaging. Rapid NMR imaging using low flip-angle pulses. J Magn Reson 67: 258-266
17. 2, microcirculatory function and radiosensitivity. Int J Radiat Oncol Biol Phys 40: 943-951
18. Hockel M, Schlenger, K, Aral B, Mitze M, Schaffer U and Vaupel P (1996) Association between tumor hypoxia and maligant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
19. Honess DJ and Bleehen NM (1995) Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined. Br J Cancer 72: 1175-1180
20. 31P MRS. NMR Biomed 9: 208-216
21. Kallinowski F, Schlenger KH, Runkel S, Kloes M, Stohrer M, Okunieff P and Vaupel P (1989) Blood flow, metabolism, cellular microenvironment, and growth rate of human tumour xenografts. Cancer Res 49: 3759-3764
22. Masuda T, Dobson GP and Veech RL (1990). The Gibbs-Donnan near-equilibrium system of heart. J Biol Chem 265: 20321-20334
23. 31P MRS in murine tumours. Br J Cancer 72: 905-911
24. McSheehy PJM, Robinson SP, Ojugo ACE, Cannell MB, Leach MO, Judson IR and Griffiths JR (1998) Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumours: a magnetic resonance study in vivo. Cancer Res 58: 1185-1194
25. Menke H and Vaupel P (1988) Effect of injectable or inhalational anesthetics and of neuroleptic, neuroleptanalgesic, and sedative agents on tumor blood flow. Radiat Res 114: 64-76
26. 2. J Neurochem 25: 553-558
27. Nordsmark M, Grau C, Horsman MR, Jorgensen HS and Overgaard J (1995) Relationship between tumour oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model. Acta Oncol 34: 329-334
28. 2 and radiation response in an experimental tumour model. Br J Cancer 76: 1432-1439
29. Parkins CS, Stratford MRL, Dennis MF, Stubbs M and Chaplin DJ (1997) The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia reperfusion. Br J Cancer 75: 319-323
30. Powell MEB, Hill SA, Saunders MI, Hoskin PJ and Chaplin DJ (1996) Effect of carbogen breathing on tumour microregional blood flow in humans. Radiother Oncol 41: 225-231
31. Robinson SP, Howe FA and Griffiths JR (1995) Noninvasive monitoring of carbogen-induced changes in tumor blood flow and oxygenation by functional magnetic resonance imaging. Int J Radiat Oncol Biol Phys 33: 855-859
32. Robinson SP, Rodrigues LM, Ojugo ASE, McSheehy PMJ, Howe FA and Griffiths JR (1997) The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imagine. Br J Cancer 75: 1000-1006
33. 31P MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas. Br J Cancer 75: 62-68
34. Rojas A (1991) Radiosensitisation with normobaric oxygen and carbogen. Radiother Oncol 20 (suppl. 1): 65-70
35. 31P MRS of tumour metabolism in anaesthetized vs conscious mice. NMR Biomed 7: 167-171
36. Schwickert G, Walenta S, Sundfor K, Rofstad EK and Mueller-Kleiser W (1995) Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 55: 4757-4759
37. 2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen. Cancer Res 47: 442-146
38. Spencer TL and Lehninger A (1976) L-Lactate transport in Ehrlich ascites tumour cells. Biochem J 154: 405-414
39. Stubbs M, Rodrigues L, Howe FA, Wang J, Jeong KS, Veech RL and Griffiths JR (1994) Metabolic consequences of a reversed pH gradient in rat tumours. Cancer Res 54: 4011-4016
40. Stubbs M, Veech RL and Griffiths JR (1995) Tumor metabolism: the lessons of magnetic resonance spectroscopy. Adv Enz Reg 35: 101-115
41. 31P NMR signals using the variable projection method and prior knowledge. Magn Reson Med 6: 92-98
42. Vaupel P, Schaefer C and Okunieff P (1994) Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi. NMR Biomed 7: 128-136
43. Veech RL (1991) The metabolism of lactate. NMR Biomed 4: 53-58
44. Warbury O (1930) The metabolism of tumors. Constable: London
45. Weber G (1968) Carbohydate metabolism in cancer cells and the molecular correlation concept. Naturwissenshaften 55: 418-429
46. Weber G, Stubbs M and Morris HP (1971) Metabolism of hepatomas of different growth rates in situ and during ischaemia. Cancer Res 31: 2177-2183