-
1
-
-
0032053823
-
The unique physiology of solid tumours: Opportunities and problems for cancer therapy
-
J. M. BROWN and A. J. GIACCA, The unique physiology of solid tumours: opportunities and problems for cancer therapy, Cancer Res. 58, 1408-1416 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1408-1416
-
-
Brown, J.M.1
Giacca, A.J.2
-
2
-
-
0001855136
-
Barriers to drug delivery in solid tumors
-
R. K. JAIN, Barriers to drug delivery in solid tumors, Sci. American 7, 42-49 (1994).
-
(1994)
Sci. American
, vol.7
, pp. 42-49
-
-
Jain, R.K.1
-
3
-
-
0030614893
-
2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation
-
2 gradients in solid tumors in vivo: high resolution measurements reveal a lack of correlation, Nature Med. 3, 177-182 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 177-182
-
-
Helminger, G.1
Yuan, F.2
Dellian, M.3
Jain, R.K.4
-
4
-
-
0023902264
-
Therapeutic attack of hypoxic cells of solid tumors
-
A. C. SARTORELLI, Therapeutic attack of hypoxic cells of solid tumors, Cancer Res. 48, 775-778 (1988).
-
(1988)
Cancer Res.
, vol.48
, pp. 775-778
-
-
Sartorelli, A.C.1
-
5
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
D. SHWEIKI, A. ITIN, D. SOFFER and E. KESHET, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis, Nature 359, 843-845 (1992).
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
6
-
-
0030968939
-
Targetting gene expression to hypoxic tumor cells
-
G. U. DACHS, A. V. PATTERSON, J. D. FIRTH, P. J. RATCLIFFE, K. M. S. TOWNSEND, I. J. STRATFORD and A. L. HARRIS, Targetting gene expression to hypoxic tumor cells, Nature Med. 3, 515-520 (1997).
-
(1997)
Nature Med.
, vol.3
, pp. 515-520
-
-
Dachs, G.U.1
Patterson, A.V.2
Firth, J.D.3
Ratcliffe, P.J.4
Townsend, K.M.S.5
Stratford, I.J.6
Harris, A.L.7
-
7
-
-
0030484881
-
The role of polymer conjugates in the diagnosis and treatment of cancer
-
R. DUNCAN, S. DIMITRIJEVIC and E. G. EVAGOROU, The role of polymer conjugates in the diagnosis and treatment of cancer, STP Pharma. Sciences 6, 237-263 (1996).
-
(1996)
STP Pharma. Sciences
, vol.6
, pp. 237-263
-
-
Duncan, R.1
Dimitrijevic, S.2
Evagorou, E.G.3
-
8
-
-
0029971428
-
Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
-
L. E. GERWECK and K. SEETHARAMAN, Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer, Cancer Res. 56, 1194-1198 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 1194-1198
-
-
Gerweck, L.E.1
Seetharaman, K.2
-
9
-
-
0027966042
-
The metabolic consequences of a reversed pH gradient in rat tumours
-
M. STUBBS, L. M. RODRIGUES, F. A. HOWE, J. WANG, K. S. JEONG, R. L. VEECH and J. R. GRIFFITHS, The metabolic consequences of a reversed pH gradient in rat tumours, Cancer Res. 54, 4011-4016 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 4011-4016
-
-
Stubbs, M.1
Rodrigues, L.M.2
Howe, F.A.3
Wang, J.4
Jeong, K.S.5
Veech, R.L.6
Griffiths, J.R.7
-
10
-
-
0032883946
-
Causes and consequences of acid pH in tumors: A magnetic resonance study
-
M. STUBBS, P. M. J. MCSHEEHY and J. R. GRIFFITHS, Causes and consequences of acid pH in tumors: a magnetic resonance study, Adv. Enzyme Reg. 39, 13-30 (1999).
-
(1999)
Adv. Enzyme Reg.
, vol.39
, pp. 13-30
-
-
Stubbs, M.1
Mcsheehy, P.M.J.2
Griffiths, J.R.3
-
11
-
-
0033986761
-
Tumour pH - Causes and consequences of tumour acidity and implications for treatment
-
M. STUBBS, P. M. J. MCSHEEHY, J. R. GRIFFITHS and C. L. BASHFORD, Tumour pH - causes and consequences of tumour acidity and implications for treatment, Molecular Med. Today 6, 15-19 (2000).
-
(2000)
Molecular Med. Today
, vol.6
, pp. 15-19
-
-
Stubbs, M.1
Mcsheehy, P.M.J.2
Griffiths, J.R.3
Bashford, C.L.4
-
12
-
-
0031981322
-
Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: Role of the transmembrane pH gradient
-
S. V. KOZIN and L. E. GERWECK, Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient, Brit. J. Cancer 77, 1580-1585 (1998).
-
(1998)
Brit. J. Cancer
, vol.77
, pp. 1580-1585
-
-
Kozin, S.V.1
Gerweck, L.E.2
-
13
-
-
0030856115
-
Cellular pharmacokinetics of camptothecin and topotecan at normal and acidic pH
-
A. GABR, A. KUIN, M. AALDERS, H. EL-GAWLY and L. A. SMETS, Cellular pharmacokinetics of camptothecin and topotecan at normal and acidic pH, Cancer Res. 57, 4811-4816 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4811-4816
-
-
Gabr, A.1
Kuin, A.2
Aalders, M.3
El-Gawly, H.4
Smets, L.A.5
-
14
-
-
0019277437
-
Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells
-
R. M. WOHLHUETER, R. S. MCIVOR and P. G. W. PLAGEMANN, Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells, J. Cellular Physiol. 104, 309-319 (1980).
-
(1980)
J. Cellular Physiol.
, vol.104
, pp. 309-319
-
-
Wohlhueter, R.M.1
Mcivor, R.S.2
Plagemann, P.G.W.3
-
16
-
-
0030696971
-
Nuclear magnetic resonance spectroscopy of cancer
-
S. P. ROBINSON, S. BARTON, P. M. J. MCSHEEHY and J. R. GRIFFITHS, Nuclear magnetic resonance spectroscopy of cancer, Brit. J. Radiology 70, S60-S69 (1997).
-
(1997)
Brit. J. Radiology
, vol.70
-
-
Robinson, S.P.1
Barton, S.2
Mcsheehy, P.M.J.3
Griffiths, J.R.4
-
17
-
-
0025043987
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics
-
19F nuclear magnetic resonance spectroscopy pharmacokinetics, J. Clin. Oncol. 8, 1868-1873 (1990).
-
(1990)
J. Clin. Oncol.
, vol.8
, pp. 1868-1873
-
-
Presant, C.A.1
Wolf, W.2
Albright, M.J.3
Servis, K.L.4
Ring, R.5
Atkinson, D.6
-
18
-
-
0028231298
-
Association of intratumoral pharmacokinetics of 5-fluorouracil with clinical response
-
C. A. PRESANT, W. WOLF, C. WALUCH, C. WISEMAN, P. KENNEDY, D. BLAYNAY and R. R. BRECHNER, Association of intratumoral pharmacokinetics of 5-fluorouracil with clinical response, The Lancet 343, 1184-1185 (1994).
-
(1994)
The Lancet
, vol.343
, pp. 1184-1185
-
-
Presant, C.A.1
Wolf, W.2
Waluch, C.3
Wiseman, C.4
Kennedy, P.5
Blaynay, D.6
Brechner, R.R.7
-
19
-
-
0031912871
-
Influence of pH on the uptake of 5-Fluorouracil into isolated tumour cells
-
A. S. E. OJUGO, P. M. J. MCSHEEHY, M. STUBBS, G. ALDER, C. L. BASHFORD, R. J. MAXWELL, M. O. LEACH, I. R. JUDSON and J. R. GRIFFITHS, Influence of pH on the uptake of 5-Fluorouracil into isolated tumour cells, Brit. J. Cancer 77, 873-879 (1998).
-
(1998)
Brit. J. Cancer
, vol.77
, pp. 873-879
-
-
Ojugo, A.S.E.1
Mcsheehy, P.M.J.2
Stubbs, M.3
Alder, G.4
Bashford, C.L.5
Maxwell, R.J.6
Leach, M.O.7
Judson, I.R.8
Griffiths, J.R.9
-
20
-
-
0032521207
-
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumours: A magnetic resonance study in vivo
-
P. J. M. MCSHEEHY, S. P. ROBINSON, A. S. E. OJUGO, M. B. CANNELL, M. O. LEACH, I. R. JUDSON and J. R. GRIFFITHS, Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumours: a magnetic resonance study in vivo, Cancer Res. 58, 1185-1194 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1185-1194
-
-
Mcsheehy, P.J.M.1
Robinson, S.P.2
Ojugo, A.S.E.3
Cannell, M.B.4
Leach, M.O.5
Judson, I.R.6
Griffiths, J.R.7
-
21
-
-
41949093884
-
Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy
-
R. J. ORDIDGE, A. CONNELLY and J. A. B. LOHMAN, Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy, J. Magn. Reson. 66, 283-294 (1986).
-
(1986)
J. Magn. Reson.
, vol.66
, pp. 283-294
-
-
Ordidge, R.J.1
Connelly, A.2
Lohman, J.A.B.3
-
23
-
-
0028787621
-
31P MRS in murine tumours
-
31P MRS in murine tumours, Brit. J. Cancer 72, 905-911 (1995).
-
(1995)
Brit. J. Cancer
, vol.72
, pp. 905-911
-
-
Mccoy, C.L.1
Parkins, C.S.2
Chaplin, D.J.3
Griffiths, J.R.4
Rodrigues, L.M.5
Stubbs, M.6
-
25
-
-
0028214088
-
Non-invasive in vivo measurements using a fluorinated pH probe and fluorine-19 magnetic resonance spectroscopy
-
T. FRENZEL, S. KOHLER, H. BAUER, U. NIEDBALLA and H. J. WEINMANN, Non-invasive in vivo measurements using a fluorinated pH probe and fluorine-19 magnetic resonance spectroscopy, Invest. Radiol. 29, S220-S222 (1994).
-
(1994)
Invest. Radiol.
, vol.29
-
-
Frenzel, T.1
Kohler, S.2
Bauer, H.3
Niedballa, U.4
Weinmann, H.J.5
-
26
-
-
0019554835
-
Intracellular pH
-
A. ROOS and W. F. BORON, Intracellular pH, Physiol. Rev. 61, 296-434 (1981).
-
(1981)
Physiol. Rev.
, vol.61
, pp. 296-434
-
-
Roos, A.1
Boron, W.F.2
-
27
-
-
0031424746
-
31P magnetic resonance spectroscopy
-
31P magnetic resonance spectroscopy, Eur. J. Cancer 33, 2418-2427 (1997).
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 2418-2427
-
-
Mcsheehy, P.M.J.1
Seymour, M.T.2
Ojugo, A.S.E.3
Rodrigues, L.M.4
Leach, M.O.5
Judson, I.R.6
Griffiths, J.R.7
-
28
-
-
0011913143
-
Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms, animal cells and plant cells
-
E. J. BOWMAN, A. SIEBERS and K. ALTENDORF, Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells and plant cells, Proc. Natl. Acad Sci. 85, 7972-7976 (1988).
-
(1988)
Proc. Natl. Acad Sci.
, vol.85
, pp. 7972-7976
-
-
Bowman, E.J.1
Siebers, A.2
Altendorf, K.3
-
31
-
-
0029799321
-
A new strategy for the therapy of pancreatic cancer by a proton pump inhibitor
-
T. OHTA, H. ARAKAWA, F. FUTAGAMI, S. FUSHIDA, H. KITAGAWA, M. KAYAHARA, T. NAGAKAWA, I. MIYAZAKI, M. NUMATA and S. OHKUMA, A new strategy for the therapy of pancreatic cancer by a proton pump inhibitor, Japanese J. Cancer & Chemother. 23, 1660-1664 (1996).
-
(1996)
Japanese J. Cancer & Chemother.
, vol.23
, pp. 1660-1664
-
-
Ohta, T.1
Arakawa, H.2
Futagami, F.3
Fushida, S.4
Kitagawa, H.5
Kayahara, M.6
Nagakawa, T.7
Miyazaki, I.8
Numata, M.9
Ohkuma, S.10
-
32
-
-
0029751950
-
A reaction-diffusion model of cancer invasion
-
R. A. GATENBY and E. T. GAWLINSKI, A reaction-diffusion model of cancer invasion, Cancer Res. 56, 5745-5753 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 5745-5753
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
-
33
-
-
0032948555
-
The effects of hyperoxic and hypercarbic gases on tumour blood flow
-
T. J. DUNN, R. D. BRAUN, W. E. RHEMUS, G. L. ROSNER, T. W. SECOMB, G. M. TOZER, D. J. CHAPLIN and M. W. DEWHIRST, The effects of hyperoxic and hypercarbic gases on tumour blood flow, Brit. J. Cancer 80, 117-126 (1999).
-
(1999)
Brit. J. Cancer
, vol.80
, pp. 117-126
-
-
Dunn, T.J.1
Braun, R.D.2
Rhemus, W.E.3
Rosner, G.L.4
Secomb, T.W.5
Tozer, G.M.6
Chaplin, D.J.7
Dewhirst, M.W.8
-
34
-
-
0028856360
-
Noninvasive monitoring of carbogen-induced changes in tumour blood flow and oxygenation by functional magnetic resonance imaging
-
S. P. ROBINSON, F. A. HOWE and J. R. GRIFFITHS, Noninvasive monitoring of carbogen-induced changes in tumour blood flow and oxygenation by functional magnetic resonance imaging, Int. J. Radiat. Oncol. Biol. Phys. 33, 855-859 (1995).
-
(1995)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.33
, pp. 855-859
-
-
Robinson, S.P.1
Howe, F.A.2
Griffiths, J.R.3
-
35
-
-
0031858408
-
On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors
-
K. G. HELMER, S. HANS and C. H. SOTAK, On the correlation between the water diffusion coefficient and oxygen tension in RIF-1 tumors, NMR Biomed. 11, 120-130 (1998).
-
(1998)
NMR Biomed.
, vol.11
, pp. 120-130
-
-
Helmer, K.G.1
Hans, S.2
Sotak, C.H.3
-
36
-
-
0032904346
-
Enhancement of chemotherapy by manipulation of tumour pH
-
N. RAGHUNAND, X. HE, R. VAN SLUIS, B. MAHONEY, B. BAGGETT and C. W. TAYLOR et al., Enhancement of chemotherapy by manipulation of tumour pH, Brit. J. Cancer 80, 1005-1011 (1999).
-
(1999)
Brit. J. Cancer
, vol.80
, pp. 1005-1011
-
-
Raghunand, N.1
He, X.2
Van Sluis, R.3
Mahoney, B.4
Baggett, B.5
Taylor, C.W.6
-
37
-
-
0027303708
-
19F magnetic resonance spectroscopy in patients with colorectal cancer: A pilot study
-
19F magnetic resonance spectroscopy in patients with colorectal cancer: a pilot study, Ann. Oncol. 4, 597-602 (1993).
-
(1993)
Ann. Oncol.
, vol.4
, pp. 597-602
-
-
Findlay, M.P.N.1
Leach, M.O.2
Cunningham, D.3
Collins, D.J.4
Payne, G.S.5
Glaholm, J.6
Mansi, J.L.7
Mccready, V.R.8
-
38
-
-
0028281081
-
19F NMR study during 5FU chemotherapy in patients with metastases of colorectal adenocarcinoma
-
19F NMR study during 5FU chemotherapy in patients with metastases of colorectal adenocarcinoma, Mag. Reson. Imaging 12, 497-511 (1994).
-
(1994)
Mag. Reson. Imaging
, vol.12
, pp. 497-511
-
-
Schlemmer, H.-P.1
Bachert, P.2
Semmler, W.3
Hohenberger, P.4
Schlag, P.5
Jorenz, W.J.6
Van Kaick, G.7
-
39
-
-
0032997486
-
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine and its analogue benzylguanidine
-
A. KUIN, M. AALDERS, M. LAMFERS, D. J. VAN ZUIDAM, M. ESSERS, J. H. BEIJNEN and L. A. SMETS, Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine and its analogue benzylguanidine, Brit. J. Cancer 79, 793-801 (1999).
-
(1999)
Brit. J. Cancer
, vol.79
, pp. 793-801
-
-
Kuin, A.1
Aalders, M.2
Lamfers, M.3
Van Zuidam, D.J.4
Essers, M.5
Beijnen, J.H.6
Smets, L.A.7
-
40
-
-
0026720341
-
Effects of agents which inhibit the regulation of intracellular pH on murine solid tumors
-
K. W. NEWELL, P. WOOD, I. STRATFORD and I. TANNOCK, Effects of agents which inhibit the regulation of intracellular pH on murine solid tumors, Brit. J. Cancer 66, 311-317 (1992).
-
(1992)
Brit. J. Cancer
, vol.66
, pp. 311-317
-
-
Newell, K.W.1
Wood, P.2
Stratford, I.3
Tannock, I.4
-
41
-
-
0021137784
-
Plasma membrane potential of Lettre cells does not depend on cation gradients but on pumps
-
C. L. BASHFORD and C. A. PASTERNAK, Plasma membrane potential of Lettre cells does not depend on cation gradients but on pumps, J. Membrane Biol. 79, 275-284 (1984).
-
(1984)
J. Membrane Biol.
, vol.79
, pp. 275-284
-
-
Bashford, C.L.1
Pasternak, C.A.2
-
42
-
-
0003673133
-
-
Blackie, London & Glasgow, UK
-
R. HARRISON and G. G. LUNT, Biological Membranes, Structure and Function. 2nd edition. Blackie, London & Glasgow, UK, (1980).
-
(1980)
Biological Membranes, Structure and Function. 2nd Edition
-
-
Harrison, R.1
Lunt, G.G.2
|