PKC-δ-dependent pathways contribute to PDGF-stimulated ERK1/2 activation in vascular smooth muscle

American Journal of Physiology - Cell Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Ginnan, Roman ^a   Singer, Harold A ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Phospholipase C ; Protein kinase C ; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ADENOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHORBOL ESTER; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; ROTTLERIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PRKCD PROTEIN, RAT; PROTEIN KINASE C;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BLOOD VESSEL INJURY; CELL GROWTH; CELL MIGRATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; INTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL CULTURE; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; PHOSPHOLIPASE C; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 19644379805     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00499.2004     Document Type: Article

References (55)

1. Alimandi M, Heidaran MA, Gutkind JS, Zhang J, Ellmore N, Valius M, Kazlauskas A, Pierce JH, and Li W. PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene 15: 585-593, 1997.
2. Barry ST and Critchley DR. The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions. J Cell Sci 107: 2033-2045, 1994.
3. Benes C and Soltoff SP. Modulation of PKCδ tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases. Am J Physiol Cell Physiol 280: C1498-C1510, 2001.
4. Berk BC. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev 81: 999-1030, 2001.
5. Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L, and Courtneidge SA. SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol 20: 9018-9027, 2000.
6. Booz GW and Baker KM. Protein kinase C in angiotensin II signalling in neonatal rat cardiac fibroblasts. Role in the mitogenic response. Ann NY Acad Sci 752: 158-167, 1995.
7. Bornfeldt KE, Raines EW, Graves LM, Skinner MP, Krebs EG, and Ross R. Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann NY Acad Sci 766: 416-430, 1995.
8. Burnstock G. Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol 22: 364-373, 2002.
9. Busuttil SJ, Morehouse DL, Youkey JR, and Singer HA. Antisense suppresssion of protein kinase C-α and -δ in vascular smooth muscle. J Surg Res 63: 137-142, 1996.
10. Cantley LC. Growth factors bind receptor tyrosine kinases to stimulate cell survival, cell division, cell growth, and cytoskeletal rearrangement. Sci STKE 2003: tr8, 2003.
11. Carpenter L, Cordery D, and Biden TJ. Inhibition of protein kinase Cδ protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis. Diabetes 51: 317-324, 2002.
12. Crosby D and Poole AW. Physical and functional interaction between protein kinase Cδ and Fyn tyrosine kinase in human platelets. J Biol Chem 278: 24533-24541, 2003.
13. Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, and Yuspa SH. Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase Cδ. J Biol Chem 271: 5325-5331, 1996.
14. Duckworth BC and Cantley LC. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem 272: 27665-27670, 1997.
15. 411 in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J Biol Chem 274: 36843-36851, 1999.
16. Eguchi S, Numaguchi K, Iwasaki H, Matsumoto T, Yamakawa T, Utsunomiya H, Motley ED, Kawakatsu H, Owada KM, Hirata Y, Marumo F, and Inagami T. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem 273: 8890-8896, 1998.
17. Geisterfer AA, Peach MJ, and Owens GK. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62: 749-756, 1988.
18. 2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle. Am J Physiol Cell Physiol 286: C1281-C1289, 2004.
19. Ginnan R and Singer HA. CaM kinase II-dependent activation of tyrosine kinases and ERK1/2 in vascular smooth muscle. Am J Physiol Cell Physiol 282: C754-C761, 2002.
20. Gschwendt M. Protein kinase Cδ. Eur J Biochem 259: 555-564, 1999.
21. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, and Johannes FJ. Inhibition of protein kinase Cμ by various inhibitors. Differentiation from protein kinase C isoenzymes. FEBS Lett 392: 77-80, 1996.
22. Gschwendt M, Kielbassa K, Kittstein W, and Marks F. Tyrosine phosphorylation and stimulation of protein kinase Cδ from porcine spleen by Src in vitro. Dependence on the activated state of protein kinase Cδ. FEBS Lett 347: 85-89, 1994.
23. Gschwendt M, Muller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G, and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199: 93-98, 1994.
24. Habib T, Herrera R, and Decker SJ. Activators of protein kinase C stimulate association of She and the PEST tyrosine phosphatase. J Biol Chem 269: 25243-25246, 1994.
25. Haller H, Lindschau C, Maasch C, Olthoff H, Kurscheid D, and Luft FC. Integrin-induced protein kinase Cα and Cε translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ Res 82: 157-165, 1998.
26. Hauck CR, Hsia DA, and Schlaepfer DD. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem 275: 41092-41099, 2000.
27. Heidkamp MC, Bayer AL, Martin JL, and Samarel AM. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase Cε and 5 in neonatal rat ventricular myocytes. Circ Res 89: 882-890, 2001.
28. Iwabu A, Smith K, Allen FD, Lauffenburger DA, and Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase Cδ-dependent pathway. J Biol Chem 279: 14551-14560, 2004.
29. Keranen LM, Dutil EM, and Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5: 1394-1403, 1995.
30. Klinghoffer RA, Duckworth B, Valius M, Cantley L, and Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 16: 5905-5914, 1996.
31. Klinghoffer RA, Sachsenmaier C, Cooper JA, and Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18: 2459-2471, 1999.
32. 2-treated cells and its activation by tyrosine kinase in vitro. Proc Natl Acad Sci USA 98: 6587-6592, 2001.
33. Li C, Wernig F, Leitges M, Hu Y, and Xu Q. Mechanical stress-activated PKCS regulates smooth muscle cell migration. FASEB J 17: 2106-2108, 2003.
34. Li W, Chen XH, Kelley CA, Alimandi M, Zhang J, Chen Q, Bottaro DP, and Pierce JH. Identification of tyrosine 187 as a protein kinase C-δ phosphorylation site. J Biol Chem 271: 26404-26409, 1996.
35. Li W, Mischak H, Yu JC, Wang LM, Mushinski JF, Heidaran MA, and Pierce JH. Tyrosine phosphorylation of protein kinase C-δ in response to its activation. J Biol Chem 269: 2349-2352, 1994.
36. Li W, Yu JC, Shin DY, and Pierce JH. Characterization of a protein kinase C-δ (PKC-δ) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-δ enzymatic activity. J Biol Chem 270: 8311-8318, 1995.
37. Li X, Lee JW, Graves LM, and Earp HS. Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway. EMBO J 17: 2574-2583, 1998.
38. Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, and Giese NA. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 62: 3729-3735, 2002.
39. Matassa AA, Kalkofen RL, Carpenter L, Biden TJ, and Reyland ME. Inhibition of PKCα induces a PKCδ-dependent apoptotic program in salivary epithelial cells. Cell Death Differ 10: 269-277, 2003.
40. Moriya S, Kazlauskas A, Akimoto K, Hirai S, Mizuno K, Takenawa T, Fukui Y, Watanabe Y, Ozaki S, and Ohno S. Platelet-derived growth factor activates protein kinase Cε through redundant and independent signaling pathways involving phospholipase Cγ or phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 93: 151-155, 1996.
41. Nakashima S. Protein kinase Cα (PKCα): regulation and biological function. J Biochem (Tokyo) 132: 669-675, 2002.
42. Newton AC. Protein kinase C: structure function and regulation. J Biol Chem 270: 28495-28498, 1995.
43. O'Carroll SJ, Hall AR, Myers CJ, Braithwaite AW, and Dix BR. Quantifying adenoviral titers by spectrophotometry. Biotechniques 28: 408-410, 412, 2000.
44. Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75: 487-517, 1995.
45. Parsons JT and Parsons SJ. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr Opin Cell Biol 9: 187-192, 1997.
46. Pearson G, Robinson F, Beers GT, Xu BE, Karandikar M, Berman K, and Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183, 2001.
47. Robin P, Boulven I, Bôle-Feysot C, Tanfin Z, and Leiber D. Contribution of PKC-dependent and independent processes in the temporal regulation of ERK by ET-I, EGF and PDGF in rat myometrial cells: role in proliferation. Am J Physiol Cell Physiol 286: C798-C806, 2004.
48. Ross R, Masuda J, and Raines EW. Cellular interactions, growth factors, and smooth muscle proliferation in atherogenesis. Ann NY Acad Sci 598: 102-112, 1990.
49. Saito Y, Hojo Y, Tanimoto T, Abe J, and Berk BC. Protein kinase C-α and protein kinase C-ε are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-23222, 2002.
50. Shah BH, Farshori MP, Jambusaria A, and Catt KJ. Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation. J Biol Chem 278: 19118-19126, 2003.
51. Singer HA. Protein kinase C. In: Biochemistry of Smooth Muscle Contraction, edited by Bárány M. New York: Academic, 1996, chapt. 12, p. 155-166.
52. Stetak A, Csermely P, Ullrich A, and Keri G. Physical and functional interactions between protein tyrosine phosphatase a, PI 3-kinase, and PKCδ. Biochem Biophys Res Commun 288: 564-572, 2001.
53. Takahashi T, Kawahara Y, Okuda M, Ueno H, Takeshita A, and Yokoyama M. Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J Biol Chem 272: 16018-16022, 1997.
54. Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, and Soriano P. Retention of PDGFR-β function in mice in the absence of phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways. Genes Dev 14: 3179-3190, 2000.
55. Van Dijk MC, Hilkmann H, and van Blitterswijk WJ. Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1. Biochem J 325: 303-307, 1997.