Antisense suppression of protein kinase C-α and -δ in vascular smooth muscle

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 137-142

  Busuttil, S J ^a   Morehouse, D L ^a   Youkey, J R ^a   Singer, H A ^b  

^a GEISINGER MEDICAL CENTER   (United States)

^b WEIS CENTER FOR RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LIPOSOME; MITOGEN ACTIVATED PROTEIN KINASE; OLIGODEOXYNUCLEOTIDE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; 1,2 DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; 1,2-DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; ANTISENSE OLIGONUCLEOTIDE; DRUG CARRIER; ISOENZYME; PHOSPHATIDYLETHANOLAMINE; PRKCD PROTEIN, RAT; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; IMAGE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SPRAGUE DAWLEY RAT;

ANIMALS; AORTA; BASE SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; DRUG CARRIERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOENZYMES; KINETICS; LIPOSOMES; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; OLIGONUCLEOTIDES, ANTISENSE; PHORBOL 12,13-DIBUTYRATE; PHOSPHATIDYLETHANOLAMINES; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0029665799     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0236     Document Type: Conference Paper

References (26)

1. Clowes, A. W., and Reidy, M. A. Prevention of stenosis after vascular reconstruction: pharmacologic control of intimal hyperplasia - a review. J. Vasc. Surg. 13: 885, 1991.
2. Singer, H. A. Protein kinase C. In M. Barany (Ed.), Biochemistry of Smooth Muscle Contraction, pp. 155-165. New York: Academic Press, 1996.
3. Pukac, L. A., Ottlinger, M. E., and Karnovsky, M. J. Heparin suppresses specific second messenger pathways for protoongogene expression in rat vascular smoooth muscle cells. J. Biol Chem. 267: 3703, 1992.
4. T. Au, Y. P., Montgomery, K. F., and Clowes, A. W. Heparin inhibits collagenase gene expression mediated by phorbol ester-responsive element in primate arterial smooth muscle cells. Circ. Res. 70: 1062, 1992.
5. Kenagy, R. D., Nikkari, S. T., Welgus, H. G., and Clowes, A. W. Heparin inhibits the induction of three matrix metalloproteinases (stromolysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells. J. Clin. Invest. 93: 1987, 1994.
6. Castellot, J. J., Pukac, A., Caleb, B. L., Wright, T. C., and Karnovsky, M. J. Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells. J. Cell Biol. 109: 3147, 1989.
7. 1/S inhibition. Exp. Cell Res. 208: 311, 1993.
8. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol ester. J. Biol. Chem. 257: 7847, 1982.
9. Langan, E. M., Youkey, J. R., Elmore, J. R., Franklin, D. P., and Singer, H. A. Regulation of MAP kinase activity by growth stimuli in vascular smooth muscle. J. Surg. Res. 57: 215, 1994.
10. Pelech, S. L., Charest, D. L., Mordret, G. P., Siow, Y. L., Palaty, C., Campbell, D., Charlton, L., Samiei, M., and Sanghera, J. S. Networking with mitogen-activated protein kinases. Mol. Cell. Biochem. 127/128: 157, 1993.
11. Blenis, J. Signal transduction via the MAP kinases: proceed at your own RSK Proc. Natl. Acad. Sci. USA 90: 5889, 1993.
12. Helene, C., and Toulme, J.-J. Specific regulation of gene expression by antisense, sense, and antigene nucleic acids. Biochim. Biophys. Acta 1049: 99, 1990.
13. Wagner, R. W. Gene inhibition using antisense oligodexynucleo-tides. Nature 372: 333, 1994.
14. Wagner, R. W., Matteucci, M. D., Lewis, J. G., Gutierrez, A. J., Moulds, C., and Froehler, B. C. Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science 260: 1510, 1993.
15. Dean, N. M., McKay, R., Condon, T. P., and Bennett, F. C. Inhibition of protein kinase C-expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J. Biol. Chem. 269: 16416, 1994.
16. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215: 403, 1990.
17. Dean, N. M., and McKay, R. Inhibition of protein kinase C-expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 91: 11762, 1994.
18. Sozeri, O., Vollmer, K., Liyange, M., Firth, D., Kour, G., Mark, G. E., III, and Stabel, S. Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene 7: 2259, 1992.
19. Perletti, G. P., Smeraldi, C., Porro, D., and Piccinini, F. Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells. Biochem. Biophys. Res. Commun. 205: 1589, 1994.
20. Simons, M., and Rosenberg, R. D. Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro. Circ. Res. 70: 835, 1992.
21. Villa, A. E., Guzman, L. A., Poptic, E. J., Labhasetwar, V., D'Souza, S., Farrell, C. L., Plow, E. F., Levy, R. J., DiCorleto, P. E., and Topol, E. J. Effects of antisense c-myb oligonucleo-tides on vascular smooth muscle cell proliferation and response to vessel wall injury. Circ Res. 76: 505, 1995.
22. Shi, Y., Fard, A., Galeo, A., Hutchinson, H. G., Vermani, P., Dodge, G. R., Hall, D. J., Shaheen, F., and Zalewski, A. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation 90: 944, 1994.
23. Morishita, R., Gibbons, G. H., Ellison, K. E., Nakajima, M., Zhang, L., Kaneda, Y., Ogihara, T., and Dzau, V. J. Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad. Sci. USA 90: 8474, 1993.
24. Murray, A. W., Fourier, A., and Hardy, S. J. Proteolytic activation of protein kinase C: a physiological reaction? Trends Biochem. Sci. 12: 53, 1987.
25. Lesh, R. A., Somlyo, A. P., Owens, G. K., and Somlyo, A. V. Reversible permeabilization. A novel technique for the intracellular introduction of antisense oligodeoxnucleotides into intact smooth muscle. Circ. Res. 77: 220, 1995.
26. 2+ in angiotensin II-induced mitogenesis of cardiac fibroblasts. Am. J. Physiol. 267: C1308, 1994.